Mitochondrial Membrane Permeabilization in Cell Death
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Abstract
References (903)
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The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore
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Mitochondrial permeability transition is a central coordinating event of apoptosis.
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Structural basis of IAP recognition by Smac/DIABLO
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Mitochondrial permeability transition and oxidative stress
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Structural and biochemical basis of apoptotic activation by Smac/DIABLO
2000 • 842 citations
Expanding insights of mitochondrial dysfunction in Parkinson's disease
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Glycogen Synthase Kinase-3 Regulates Mitochondrial Outer Membrane Permeabilization and Apoptosis by Destabilization of MCL-1
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The internal structure of mitochondria
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Classification of cell death: recommendations of the Nomenclature Committee on Cell Death
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Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia
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VDAC2 Inhibits BAK Activation and Mitochondrial Apoptosis
2003 • 789 citations
Properties of the Permeability Transition Pore in Mitochondria Devoid of Cyclophilin D
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Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis
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The central executioners of apoptosis: caspases or mitochondria?
1998 • 772 citations
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
2000 • 754 citations
Cell Surface Trafficking of Fas: A Rapid Mechanism of p53-Mediated Apoptosis
1998 • 752 citations
Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex
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Mitochondrial fission in apoptosis
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The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis: Figure 1
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Life in the balance: how BH3-only proteins induce apoptosis
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Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium Signals
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Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process
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Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis
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NEW EMBO MEMBERS' REVIEW: Lysosomal cysteine proteases: facts and opportunities
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Regulation of apoptosis by endoplasmic reticulum pathways
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Bax-induced Caspase Activation and Apoptosis via Cytochromec Release from Mitochondria Is Inhibitable by Bcl-xL
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The permeability transition pore complex: another view
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The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins
1998 • 700 citations
Caspase-independent cell death
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Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins
2002 • 699 citations
Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling
2006 • 695 citations
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
2003 • 694 citations
Lysosomes in cell death
2004 • 683 citations
Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis
1999 • 680 citations
Transient and Long-Lasting Openings of the Mitochondrial Permeability Transition Pore Can Be Monitored Directly in Intact Cells by Changes in Mitochondrial Calcein Fluorescence
1999 • 664 citations
Mitochondrial Binding of Hexokinase II Inhibits Bax-induced Cytochrome c Release and Apoptosis
2002 • 657 citations
Cytochrome c Release and Apoptosis Induced by Mitochondrial Targeting of Nuclear Orphan Receptor TR3
2000 • 651 citations
Inflammation and necrosis promote tumour growth
2004 • 646 citations
Apoptosis-based therapies
2002 • 646 citations
Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions
1998 • 645 citations
Conversion of Bcl-2 from Protector to Killer by Interaction with Nuclear Orphan Receptor Nur77/TR3
2004 • 644 citations
Phosphorylation and Inactivation of BAD by Mitochondria-Anchored Protein Kinase A
1999 • 635 citations
14-3-3 Proteins and Survival Kinases Cooperate to Inactivate BAD by BH3 Domain Phosphorylation
2000 • 634 citations
The role of carotenoids in the prevention of human pathologies
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Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis
2003 • 624 citations
hFis1, a Novel Component of the Mammalian Mitochondrial Fission Machinery
2003 • 615 citations
Bcl-2-mediated alterations in endoplasmic reticulum Ca 2+ analyzed with an improved genetically encoded fluorescent sensor
2004 • 613 citations
Hexokinase-Mitochondria Interaction Mediated by Akt Is Required to Inhibit Apoptosis in the Presence or Absence of Bax and Bak
2004 • 612 citations
Relationship between configuration, function, and permeability in calcium-treated mitochondria.
1976 • 610 citations
BNIP3 and Genetic Control of Necrosis-Like Cell Death through the Mitochondrial Permeability Transition Pore
2000 • 605 citations
AIF deficiency compromises oxidative phosphorylation
2004 • 600 citations
The autophagosomal–lysosomal compartment in programmed cell death
2001 • 599 citations
The mitochondrial permeability transition initiates autophagy in rat hepatocytes
2001 • 596 citations
The harlequin mouse mutation downregulates apoptosis-inducing factor
2002 • 595 citations
Disruption of Mitochondrial Function during Apoptosis Is Mediated by Caspase Cleavage of the p75 Subunit of Complex I of the Electron Transport Chain
2004 • 587 citations
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis
2003 • 586 citations
Targeting an antioxidant to mitochondria decreases cardiac ischemia‐reperfusion injury
2005 • 581 citations
The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action
2001 • 578 citations
Mitochondrial creatine kinase in human health and disease
2005 • 576 citations
Role of the Mitochondrial Permeability Transition in Myocardial Disease
2003 • 575 citations
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
2005 • 554 citations
HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins
2002 • 550 citations
Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization
1999 • 546 citations
Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL
2001 • 546 citations
Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia
1999 • 544 citations
p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD
2001 • 540 citations
Redox Control of Cell Death
2002 • 531 citations
PUMA Couples the Nuclear and Cytoplasmic Proapoptotic Function of p53
2005 • 527 citations
Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of Jurkat cells
1999 • 518 citations
Emerging functions of mammalian mitochondrial fusion and fission
2005 • 515 citations
Caspase-2 Induces Apoptosis by Releasing Proapoptotic Proteins from Mitochondria
2002 • 511 citations
VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release
2001 • 507 citations
Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis
2000 • 501 citations
Bcl-xL Prevents Cell Death following Growth Factor Withdrawal by Facilitating Mitochondrial ATP/ADP Exchange
1999 • 496 citations
Death receptors in chemotherapy and cancer
2004 • 495 citations
Small-cell lung cancer
2005 • 494 citations
The Adenine Nucleotide Translocase: A Central Component of the Mitochondrial Permeability Transition Pore and Key Player in Cell Death
2003 • 491 citations
Endoplasmic Reticulum Stress-induced Apoptosis
2006 • 490 citations
Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death
2002 • 485 citations
Huntingtin and the molecular pathogenesis of Huntington's disease
2004 • 485 citations
Bax-independent inhibition of apoptosis by Bcl-XL
1996 • 484 citations
The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death
1997 • 470 citations
Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis
2003 • 468 citations
Bax and Bak Coalesce into Novel Mitochondria-Associated Clusters during Apoptosis
2001 • 466 citations
Reduced Loading of Intracellular Ca2+ Stores and Downregulation of Capacitative Ca2+Influx in Bcl-2–Overexpressing Cells
2000 • 462 citations
Caspase-3-dependent Cleavage of Bcl-2 Promotes Release of Cytochrome c
1999 • 461 citations
Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release
2001 • 460 citations
Calcium signaling and apoptosis
2003 • 457 citations
Selective Disruption of Lysosomes in HeLa Cells Triggers Apoptosis Mediated by Cleavage of Bid by Multiple Papain-like Lysosomal Cathepsins
2004 • 454 citations
Mitochondrial Targets of Drug Toxicity
2000 • 452 citations
The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore
2000 • 449 citations
Protein Kinase Cε Interacts With and Inhibits the Permeability Transition Pore in Cardiac Mitochondria
2003 • 449 citations
BAX-dependent transport of cytochrome c reconstituted in pure liposomes
2000 • 447 citations
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3
2001 • 445 citations
Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis
1996 • 440 citations
A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak
1997 • 437 citations
Clinging to life: cell to matrix adhesion and cell survival
2005 • 435 citations
Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization
2003 • 434 citations
Solution structure of the antiapoptotic protein bcl-2
2001 • 433 citations
Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria
2002 • 432 citations
Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2
2001 • 430 citations
Calpain I Induces Cleavage and Release of Apoptosis-inducing Factor from Isolated Mitochondria
2004 • 429 citations
Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival
2000 • 428 citations
The Apaf-1 apoptosome: a large caspase-activating complex
2002 • 424 citations
Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury
1997 • 422 citations
Mitochondrial ADP/ATP Carrier Can Be Reversibly Converted into a Large Channel by Ca2+
1996 • 421 citations
Translocation of SAPK/JNK to Mitochondria and Interaction with Bcl-xL in Response to DNA Damage
2000 • 421 citations
The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death
1996 • 420 citations
Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis
2004 • 420 citations
Bcl-2 decreases the free Ca 2+ concentration within the endoplasmic reticulum
2000 • 417 citations
Mitochondrial endonuclease G is important for apoptosis in C. elegans
2001 • 416 citations
Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum
2004 • 416 citations
BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death
2000 • 415 citations
Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux
1998 • 414 citations
Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways
2005 • 413 citations
BID regulation by p53 contributes to chemosensitivity
2002 • 412 citations
Ferredoxin reductase affects p53-dependent, 5-fluorouracil–induced apoptosis in colorectal cancer cells
2001 • 400 citations
Reactive Oxygen Species, Mitochondria, and NAD(P)H Oxidases in the Development and Progression of Heart Failure
2002 • 398 citations
Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils
2005 • 397 citations
Chemotherapy: targeting the mitochondrial cell death pathway
2002 • 396 citations
The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change
2001 • 390 citations
In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death
2004 • 389 citations
Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death
2003 • 388 citations
Hypoxia-Mediated Down-Regulation of Bid and Bax in Tumors Occurs via Hypoxia-Inducible Factor 1-Dependent and -Independent Mechanisms and Contributes to Drug Resistance
2004 • 385 citations
Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3
2004 • 385 citations
Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice
2004 • 383 citations
NADH Oxidase Activity of Mitochondrial Apoptosis-inducing Factor
2001 • 382 citations
The actin cytoskeleton: a key regulator of apoptosis and ageing?
2005 • 382 citations
harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-XL
1997 • 381 citations
Activation of Glycogen Synthase Kinase 3β Disrupts the Binding of Hexokinase II to Mitochondria by Phosphorylating Voltage-Dependent Anion Channel and Potentiates Chemotherapy-Induced Cytotoxicity
2005 • 381 citations
Mitochondria and Ischemia/Reperfusion Injury
2005 • 376 citations
Molecular bases of cellular iron toxicity12 1Guest Editor: Mario Comporti 2This article is part of a series of reviews on “Iron and Cellular Redox Status.” The full list of papers may be found on the homepage of the journal.
2002 • 375 citations
Mechanisms of AIF-Mediated Apoptotic DNA Degradation in Caenorhabditis elegans
2002 • 375 citations
Mitochondrial permeability transition in CNS trauma: Cause or effect of neuronal cell death?
2004 • 373 citations
Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid
1998 • 372 citations
Cyclosporin A, But Not FK 506, Protects Mitochondria and Neurons against Hypoglycemic Damage and Implicates the Mitochondrial Permeability Transition in Cell Death
1998 • 372 citations
Creatine and Cyclocreatine Attenuate MPTP Neurotoxicity
1999 • 372 citations
Granzyme A Induces Caspase-Independent Mitochondrial Damage, a Required First Step for Apoptosis
2005 • 371 citations
Discovery, Characterization, and Structure−Activity Relationships Studies of Proapoptotic Polyphenols Targeting B-Cell Lymphocyte/Leukemia-2 Proteins
2003 • 370 citations
S-Nitrosylation of mitochondrial caspases
2001 • 365 citations
Influenza Virus PB1-F2 Protein Induces Cell Death through Mitochondrial ANT3 and VDAC1
2005 • 363 citations
Heat shock protein expression independently predicts clinical outcome in prostate cancer.
2000 • 361 citations
Essential Role of Voltage-Dependent Anion Channel in Various Forms of Apoptosis in Mammalian Cells
2001 • 360 citations
Sanglifehrin A Acts as a Potent Inhibitor of the Mitochondrial Permeability Transition and Reperfusion Injury of the Heart by Binding to Cyclophilin-D at a Different Site from Cyclosporin A
2002 • 359 citations
Disturbed Ca2+signaling and apoptosis of medium spiny neurons in Huntington's disease
2005 • 357 citations
Mitochondrial potassium transport: the K+ cycle
2003 • 357 citations
Bcl-x Promotes the Open Configuration of the Voltage-dependent Anion Channel and Metabolite Passage through the Outer Mitochondrial Membrane
2001 • 356 citations
Intracellular ATP, a switch in the decision between apoptosis and necrosis
1998 • 353 citations
Pivotal Role of Mitochondrial Calcium Uptake in Neural Cell Apoptosis and Necrosis
1999 • 352 citations
Mitochondrial Participation in Ischemic and Traumatic Neural Cell Death
2000 • 350 citations
Calcium binding and translocation by the voltage-dependent anion channel: a possible regulatory mechanism in mitochondrial function
2001 • 350 citations
Transient Mitochondrial Permeability Transition Pore Opening Mediates Preconditioning-Induced Protection
2004 • 347 citations
Propionibacteria induce apoptosis of colorectal carcinoma cells via short-chain fatty acids acting on mitochondria
2002 • 344 citations
Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinases
1998 • 342 citations
Direct Activation of Mitochondrial Apoptosis Machinery by c-Jun N-terminal Kinase in Adult Cardiac Myocytes
2002 • 342 citations
Phosphorylation of Bid by Casein Kinases I and II Regulates Its Cleavage by Caspase 8
2001 • 341 citations
Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation
2001 • 340 citations
Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury
2005 • 338 citations
Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis
2000 • 337 citations
Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator
2000 • 336 citations
Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species
1997 • 336 citations
Electrophysiological Study of a Novel Large Pore Formed by Bax and the Voltage-dependent Anion Channel That Is Permeable to Cytochrome c
2000 • 335 citations
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1997 • 328 citations
Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition
2001 • 328 citations
CATHEPSIN D: AN INDEPENDENT PROGNOSTIC FACTOR FOR METASTASIS OF BREAST CANCER
1989 • 327 citations
Proteasome Inhibitors Trigger NOXA-Mediated Apoptosis in Melanoma and Myeloma Cells
2005 • 327 citations
Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury
2004 • 326 citations
Apoptosis-Inducing Factor Triggered by Poly(ADP-Ribose) Polymerase and Bid Mediates Neuronal Cell Death after Oxygen-Glucose Deprivation and Focal Cerebral Ischemia
2005 • 326 citations
Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents
2004 • 325 citations
Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis
2005 • 325 citations
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor
2003 • 324 citations
VDAC regulation by the Bcl-2 family of proteins
2000 • 323 citations
Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis
2002 • 321 citations
Involvement of Histone H1.2 in Apoptosis Induced by DNA Double-Strand Breaks
2003 • 321 citations
Up-regulation of Bcl-2 Homology 3 (BH3)-only Proteins by E2F1 Mediates Apoptosis
2004 • 316 citations
The Peutz-Jegher Gene Product LKB1 Is a Mediator of p53-Dependent Cell Death
2001 • 316 citations
Apoptosis-inducing factor: vital and lethal
2006 • 316 citations
Mitochondrial translocation of cofilin is an early step in apoptosis induction
2003 • 315 citations
Lysosomes as Targets for Cancer Therapy
2005 • 315 citations
Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice
2004 • 312 citations
Mitochondrially Associated Hepatitis B Virus X Protein Constitutively Activates Transcription Factors STAT-3 and NF-κB via Oxidative Stress
2001 • 310 citations
Do inducers of apoptosis trigger caspase-independent cell death?
2005 • 310 citations
Mitochondrial involvement in Parkinson’s disease, Huntington’s disease, hereditary spastic paraplegia and Friedreich’s ataxia
1999 • 309 citations
Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo
2001 • 308 citations
Expression of Concern: Glycogen synthase kinase 3β (GSK3β) mediates 6‐ hydroxydopamine‐induced neuronal death
2004 • 307 citations
Arsenite Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore
1999 • 307 citations
Hepatitis B Virus X Protein Colocalizes to Mitochondria with a Human Voltage-Dependent Anion Channel, HVDAC3, and Alters Its Transmembrane Potential
2000 • 306 citations
The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism
1999 • 304 citations
Flirting in Little Space: The ER/Mitochondria Ca 2+ Liaison
2004 • 303 citations
Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis
2002 • 299 citations
Functional Consequences of the Sustained or Transient Activation by Bax of the Mitochondrial Permeability Transition Pore
1999 • 295 citations
The Life Span Determinant p66Shc Localizes to Mitochondria Where It Associates with Mitochondrial Heat Shock Protein 70 and Regulates Trans-membrane Potential
2004 • 293 citations
Mitochondria and Neuronal Death/Survival Signaling Pathways in Cerebral Ischemia
2004 • 293 citations
Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease
2002 • 293 citations
Activated Mitofusin 2 Signals Mitochondrial Fusion, Interferes with Bax Activation, and Reduces Susceptibility to Radical Induced Depolarization
2005 • 292 citations
Bcl-2 Inhibition of Autophagy: A New Route to Cancer?
2006 • 290 citations
Mechanisms of ischemic injury are different in the steatotic and normal rat liver
2000 • 286 citations
The voltage-dependent anion channel-1 modulates apoptotic cell death
2005 • 286 citations
Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis
2000 • 286 citations
Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy
2005 • 286 citations
The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice
1997 • 286 citations
Targeting the prostate for destruction through a vascular address
2002 • 285 citations
Arachidonic Acid Causes Cell Death through the Mitochondrial Permeability Transition
2001 • 284 citations
Mitochondria and degenerative disorders
2001 • 284 citations
Negative and positive regulation of HIF-1: A complex network
2005 • 284 citations
Akt Inhibits Apoptosis Downstream of BID Cleavage via a Glucose-Dependent Mechanism Involving Mitochondrial Hexokinases
2003 • 284 citations
MPTP as a Mitochondrial Neurotoxic Model of Parkinson's Disease
2004 • 281 citations
Adenine Nucleotide Translocase-1, a Component of the Permeability Transition Pore, Can Dominantly Induce Apoptosis
1999 • 278 citations
Apoptosis-Inducing Factor Substitutes for Caspase Executioners in NMDA-Triggered Excitotoxic Neuronal Death
2004 • 278 citations
Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species.
2001 • 277 citations
Stoichiometry of Proton Translocation through the Respiratory Chain and Adenosine Triphosphatase Systems of Rat Liver Mitochondria
1965 • 275 citations
Specific Ablation of the Apoptotic Functions of Cytochrome c Reveals a Differential Requirement for Cytochrome c and Apaf-1 in Apoptosis
2005 • 273 citations
p53 mutation heterogeneity in cancer
2005 • 272 citations
Mitochondrial Bound Hexokinase Activity as a Preventive Antioxidant Defense
2004 • 272 citations
Bad Is a BH3 Domain-Containing Protein That Forms an Inactivating Dimer with Bcl-XL
1997 • 271 citations
Combined and Individual Mitochondrial HSP60 and HSP10 Expression in Cardiac Myocytes Protects Mitochondrial Function and Prevents Apoptotic Cell Deaths Induced by Simulated Ischemia-Reoxygenation
2001 • 271 citations
The relevance of mitochondrial membrane topology to mitochondrial function
2005 • 270 citations
Imaging the Permeability Pore Transition in Single Mitochondria
1998 • 269 citations
Control of Mitochondrial Membrane Permeabilization by Adenine Nucleotide Translocator Interacting with HIV-1 Viral Protein R and Bcl-2
2001 • 269 citations
Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria
2000 • 269 citations
6-Hydroxydopamine Lesion of the Rat Substantia Nigra: Time Course and Morphology of Cell Death
1995 • 268 citations
AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis
2004 • 268 citations
Mitochondria in cell death: novel targets for neuroprotection and cardioprotection
2003 • 265 citations
Mitochondrial intermembrane junctional complexes and their involvement in cell death
2002 • 265 citations
PK11195, a Ligand of the Mitochondrial Benzodiazepine Receptor, Facilitates the Induction of Apoptosis and Reverses Bcl-2-Mediated Cytoprotection
1998 • 264 citations
The ins and outs of mitochondrial dysfunction in NASH
2004 • 264 citations
Cellular and Molecular Pathways of Ischemic Neuronal Death
2002 • 263 citations
Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress‐induced apoptosis of rat brain astrocytes
2004 • 260 citations
Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins.
2003 • 259 citations
Quantitation of mitochondrial alterations associated with apoptosis
2002 • 257 citations
Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation
1999 • 257 citations
A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif
2000 • 257 citations
BH3-only Protein Noxa Is a Mediator of Hypoxic Cell Death Induced by Hypoxia-inducible Factor 1α
2003 • 256 citations
The permeability transition pore signals apoptosis by directing Bax translocation and multimerization
2002 • 255 citations
Mitochondrial Respiration and ATP Production Are Significantly Impaired in Striatal Cells Expressing Mutant Huntingtin
2005 • 253 citations
Glycogen Synthase Kinase-3β (GSK3β) Binds to and Promotes the Actions of p53
2003 • 253 citations
Endophilin B1 is required for the maintenance of mitochondrial morphology
2004 • 253 citations
Specific Cleavage of Mcl-1 by Caspase-3 in Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis in Jurkat Leukemia T Cells
2005 • 252 citations
Metformin Prevents High-Glucose–Induced Endothelial Cell Death Through a Mitochondrial Permeability Transition-Dependent Process
2005 • 251 citations
Thioredoxin-2 Inhibits Mitochondria-Located ASK1-Mediated Apoptosis in a JNK-Independent Manner
2004 • 250 citations
Mitochondrial Mechanisms of Neural Cell Death and Neuroprotective Interventions in Parkinson's Disease
2003 • 249 citations
Bcl-2 and Ca2+ homeostasis in the endoplasmic reticulum
2006 • 248 citations
The First α Helix of Bax Plays a Necessary Role in Its Ligand-Induced Activation by the BH3-Only Proteins Bid and PUMA
2004 • 245 citations
Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis
2000 • 244 citations
Dominant cell death induction by extramitochondrially targeted apoptosis‐inducing factor
2001 • 244 citations
On the Role of VDAC in Apoptosis: Fact and Fiction
2005 • 242 citations
The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal
2001 • 241 citations
ABAD enhances Aβ‐induced cell stress via mitochondrial dysfunction
2005 • 241 citations
Hexokinase II: The Integration of Energy Metabolism and Control of Apoptosis
2003 • 240 citations
Mammalian mitochondrial IAP binding proteins
2003 • 240 citations
p53 Translocation to Mitochondria Precedes Its Nuclear Translocation and Targets Mitochondrial Oxidative Defense Protein-Manganese Superoxide Dismutase
2005 • 239 citations
ASC is a Bax adaptor and regulates the p53–Bax mitochondrial apoptosis pathway
2004 • 236 citations
Pharmacological manipulation of cell death: clinical applications in sight?
2005 • 236 citations
Minocycline Up-regulates Bcl-2 and Protects against Cell Death in Mitochondria
2004 • 236 citations
Lead and Calcium Produce Rod Photoreceptor Cell Apoptosis by Opening the Mitochondrial Permeability Transition Pore
2000 • 235 citations
Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution
2000 • 234 citations
Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3
2004 • 234 citations
Therapeutic Effects of l‐Carnitine and Propionyl‐l‐carnitine on Cardiovascular Diseases: A Review
2004 • 233 citations
Nitric Oxide Prevents Tumor Necrosis Factor α–Induced Rat Hepatocyte Apoptosis by the Interruption of Mitochondrial Apoptotic Signaling Through S-Nitrosylation of Caspase-8
2000 • 233 citations
Calcium binding and translocation by the voltage-dependent anion channel: a possible regulatory mechanism in mitochondrial function
2001 • 232 citations
Nicotine Inactivation of the Proapoptotic Function of Bax through Phosphorylation
2005 • 232 citations
HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells
2005 • 231 citations
Calcium, mitochondria and oxidative stress in neuronal pathology
2006 • 231 citations
Propagation of the apoptotic signal by mitochondrial waves
2001 • 231 citations
Bax-type Apoptotic Proteins Porate Pure Lipid Bilayers through a Mechanism Sensitive to Intrinsic Monolayer Curvature
2002 • 229 citations
Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator
2000 • 228 citations
Silencing of the Hypoxia-Inducible Cell Death Protein BNIP3 in Pancreatic Cancer
2004 • 227 citations
Growth Factors Inactivate the Cell Death Promoter BAD by Phosphorylation of Its BH3 Domain on Ser155
2000 • 225 citations
A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth
2002 • 224 citations
Mammalian hexokinases and their abnormal expression in cancer.
2000 • 224 citations
β-Amyloid-Induced Neuronal Apoptosis Involves c-Jun N-Terminal Kinase-Dependent Downregulation of Bcl-w
2005 • 223 citations
Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth
2004 • 223 citations
P53 Mediates the Apoptotic Response to GTP Depletion after Renal Ischemia-Reperfusion
2003 • 223 citations
STAT-1 Interacts with p53 to Enhance DNA Damage-induced Apoptosis
2004 • 222 citations
Thiazolidenediones Mediate Apoptosis in Prostate Cancer Cells in Part through Inhibition of Bcl-xL/Bcl-2 Functions Independently of PPARγ
2005 • 221 citations
Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis
2005 • 221 citations
Blockade of the Mitochondrial Permeability Transition Pore Diminishes Infarct Size in the Rat after Transient Middle Cerebral Artery Occlusion
1999 • 218 citations
Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways†
2004 • 217 citations
Multiprotein complex containing succinate dehydrogenase confers mitochondrial ATP-sensitive K + channel activity
2004 • 216 citations
Intracellular Bax Translocation after Transient Cerebral Ischemia: Implications for a Role of the Mitochondrial Apoptotic Signaling Pathway in Ischemic Neuronal Death
2001 • 215 citations
The mitochondrial permeability transition in toxic, hypoxic and reperfusion injury.
1997 • 214 citations
ASalmonellaprotein causes macrophage cell death by inducing autophagy
2003 • 212 citations
Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore
1999 • 211 citations
AMID, an Apoptosis-inducing Factor-homologous Mitochondrion-associated Protein, Induces Caspase-independent Apoptosis
2002 • 211 citations
Inhibition of the Mitochondrial Permeability Transition by Creatine Kinase Substrates
2003 • 210 citations
Negative regulation of bcl-2 expression by p53 in hematopoietic cells
2001 • 210 citations
Mitochondrial permeability transitions: how many doors to the house?
2004 • 210 citations
Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis.
2003 • 209 citations
Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis
2005 • 207 citations
Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases.
1997 • 207 citations
Mitochondrial K channels in cell survival and death
2005 • 206 citations
Ca2+-dependent Control of the Permeability Properties of the Mitochondrial Outer Membrane and Voltage-dependent Anion-selective Channel (VDAC)
2006 • 206 citations
Alterations in the common fragile site gene Parkin in ovarian and other cancers
2003 • 206 citations
Overexpression of Manganese Superoxide Dismutase Prevents Alcohol-induced Liver Injury in the Rat
2001 • 205 citations
Mitotic spindle checkpoint inactivation by trichostatin A defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents
2005 • 204 citations
Cytochrome c as an electron shuttle between the outer and inner mitochondrial membranes.
1981 • 203 citations
Evidence discriminating between the Chemical and the Chemiosmotic Mechanisms of Electron Transport Phosphorylation
1965 • 201 citations
Betulinic acid: A new cytotoxic agent against malignant brain-tumor cells
1999 • 199 citations
Cytofluorometric detection of mitochondrial alterations in early CD95/Fas/APO-1-triggered apoptosis of Jurkat T lymphoma cells. Comparison of seven mitochondrion-specific fluorochromes
1998 • 196 citations
Calcineurin-Mediated BAD Dephosphorylation Activates the Caspase-3 Apoptotic Cascade in Traumatic Spinal Cord Injury
2000 • 196 citations
Inhibition of ADP/ATP Exchange in Receptor-Interacting Protein-Mediated Necrosis
2006 • 196 citations
Treatment of acute promyelocytic leukemia with arsenic trioxide without ATRA and/or chemotherapy
2005 • 195 citations
Ca 2+ Influx–Induced Sarcoplasmic Reticulum Ca 2+ Overload Causes Mitochondrial-Dependent Apoptosis in Ventricular Myocytes
2005 • 195 citations
Protein Kinase Cδ Activation Induces Apoptosis in Response to Cardiac Ischemia and Reperfusion Damage
2004 • 194 citations
The peripheral-type benzodiazepine receptor and the cardiovascular system. Implications for drug development
2005 • 194 citations
Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria
2004 • 193 citations
Paclitaxel Affects Cytosolic Calcium Signals by Opening the Mitochondrial Permeability Transition Pore
2002 • 192 citations
The Tumor Suppressor RASSF1A and MAP-1 Link Death Receptor Signaling to Bax Conformational Change and Cell Death
2005 • 191 citations
Mitochondrial dynamics and Ca2+ signaling
2006 • 191 citations
Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437
2001 • 190 citations
Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines.
2002 • 190 citations
AP-1 proteins in the adult brain: facts and fiction about effectors of neuroprotection and neurodegeneration
2001 • 190 citations
GD3 ganglioside directly targets mitochondria in a bcl‐2‐controlled fashion
2000 • 189 citations
HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim
2002 • 189 citations
K15 Protein of Kaposi’s Sarcoma-Associated Herpesvirus Is Latently Expressed and Binds to HAX-1, a Protein with Antiapoptotic Function
2002 • 189 citations
Quantitative proteomic analysis of Myc oncoprotein function
2002 • 186 citations
Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity
2005 • 186 citations
Resveratrol, a tumor‐suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl‐2
2001 • 184 citations
Gene expression changes in response to E2F1 activation
2002 • 184 citations
p53 Upregulates Death Receptor 4 Expression through an Intronic p53 Binding Site
2004 • 182 citations
Protection of cardiac mitochondria by diazoxide and protein kinase C: Implications for ischemic preconditioning
2002 • 182 citations
mtCLIC/CLIC4, an Organellular Chloride Channel Protein, Is Increased by DNA Damage and Participates in the Apoptotic Response to p53
2002 • 180 citations
Mitochondrial permeability transition in acute neurodegeneration
2002 • 180 citations
The mitochondrial ARTS protein promotes apoptosis through targeting XIAP
2004 • 179 citations
Loss of Bif-1 Suppresses Bax/Bak Conformational Change and Mitochondrial Apoptosis
2005 • 179 citations
HSP60, Bax, Apoptosis and the Heart
2005 • 179 citations
Manganese toxicity is associated with mitochondrial dysfunction and DNA fragmentation in rat primary striatal neurons
2001 • 177 citations
Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition
2000 • 177 citations
Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase.
1996 • 176 citations
Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC
2000 • 176 citations
Mitochondrial fusion and fission in the control of apoptosis
2005 • 175 citations
BH3-only BIK Regulates BAX,BAK-dependent Release of Ca2+ from Endoplasmic Reticulum Stores and Mitochondrial Apoptosis during Stress-induced Cell Death
2005 • 175 citations
Apoptosis-Inducing Factor Is a Key Factor in Neuronal Cell Death Propagated by BAX-Dependent and BAX-Independent Mechanisms
2005 • 175 citations
Bupivacaine Myotoxicity Is Mediated by Mitochondria
2002 • 174 citations
l-Carnitine inhibits cisplatin-induced injury of the kidney and small intestine
2002 • 173 citations
Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis
2004 • 172 citations
Generation and Characterization of Smac/DIABLO-Deficient Mice
2002 • 171 citations
Targeting of protein kinase C delta to mitochondria in the oxidative stress response.
2001 • 171 citations
Mechanisms of benzarone and benzbromarone-induced hepatic toxicity
2005 • 170 citations
Bcl-2 and Bax modulate adenine nucleotide translocase activity.
2003 • 168 citations
Mitochondria as a Target for Neurotoxins and Neuroprotective Agents
2003 • 168 citations
Cardiomyocytes structure, function and associated pathologies
2005 • 167 citations
Bax and Bcl-xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator
2000 • 166 citations
c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis
2003 • 165 citations
Mitochondrial membrane depolarization and the selective death of dopaminergic neurons by rotenone: protective effect of coenzyme Q10
2005 • 165 citations
Role of Translation Initiation Factor 2B in Control of Cell Survival by the Phosphatidylinositol 3-Kinase/Akt/Glycogen Synthase Kinase 3β Signaling Pathway
2002 • 164 citations
A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria
2004 • 164 citations
Variation in transcriptional regulation of cyclin dependent kinase inhibitor p21waf1/cip1 among human bronchogenic carcinomas
2005 • 164 citations
p21-Activated Kinase 5 (Pak5) Localizes to Mitochondria and Inhibits Apoptosis by Phosphorylating BAD
2003 • 163 citations
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin
2002 • 163 citations
MUC1 and Nuclear β-Catenin Are Coexpressed at the Invasion Front of Colorectal Carcinomas and Are Both Correlated with Tumor Prognosis
2004 • 163 citations
Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: support for a mitochondrial role in cardioprotection
2000 • 163 citations
Calpain Is a Major Cell Death Effector in Selective Striatal Degeneration InducedIn Vivoby 3-Nitropropionate: Implications for Huntington's Disease
2003 • 162 citations
Viral proteins targeting mitochondria: controlling cell death
2004 • 162 citations
Differential Inactivation of Caspase-8 in Lung Cancers
2002 • 162 citations
A Phase II, Pharmacokinetic, and Biological Correlative Study of Oblimersen Sodium and Docetaxel in Patients with Hormone-Refractory Prostate Cancer
2005 • 162 citations
Human Hepatitis B Virus-X Protein Alters Mitochondrial Function and Physiology in Human Liver Cells
2004 • 161 citations
Mitochondrial permeability transition pore as a target for cardioprotection in the human heart
2005 • 161 citations
Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer
1999 • 159 citations
Overexpression of glutaredoxin 2 attenuates apoptosis by preventing cytochrome c release
2004 • 159 citations
Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with Bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability
1999 • 158 citations
Epstein-Barr Virus Encodes a Novel Homolog of thebcl-2Oncogene That Inhibits Apoptosis and Associates with Bax and Bak
1999 • 158 citations
Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review).
1998 • 158 citations
Bisphosphonates in breast cancer
2005 • 157 citations
Peripheral benzodiazepine receptor ligands reverse apoptosis resistance of cancer cells in vitro and in vivo.
2002 • 157 citations
A Mitochondrial Protein, Bit1, Mediates Apoptosis Regulated by Integrins and Groucho/TLE Corepressors
2004 • 157 citations
Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70
2003 • 157 citations
Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives
2005 • 157 citations
Dysregulation of apoptosis genes in hematopoietic malignancies
2002 • 156 citations
A Novel Free Radical Scavenger, Edarabone, Protects Against Cisplatin-Induced Acute Renal Damage in Vitro and in Vivo
2003 • 156 citations
Helicobacter pylori Vacuolating Cytotoxin Induces Activation of the Proapoptotic Proteins Bax and Bak, Leading to Cytochrome c Release and Cell Death, Independent of Vacuolation
2006 • 156 citations
tBid interaction with cardiolipin primarily orchestrates mitochondrial dysfunctions and subsequently activates Bax and Bak
2005 • 156 citations
A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c
2001 • 156 citations
Requirement of Both the Second and Third BIR Domains for the Relief of X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Caspase Inhibition by Smac
2003 • 155 citations
Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis
2004 • 155 citations
Apoptosis: Mitochondrial Membrane Permeabilization – The (W)hole Story?
2003 • 155 citations
Distinct Pathways for Stimulation of Cytochrome cRelease by Etoposide
2000 • 155 citations
Bilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons
2002 • 154 citations
The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides
2005 • 152 citations
Regulation of the activity of caspases by <scp>L</scp>‐carnitine and palmitoylcarnitine
2000 • 151 citations
Mercuric compounds inhibit human monocyte function by inducing apoptosis: evidence for formation of reactive oxygen species, development of mitochondrial membrane permeability transition and loss of reductive reserve
1997 • 150 citations
Anti-apoptotic Effect of cGMP in Cultured Astrocytes
2001 • 147 citations
Electrophysiology of the inner mitochondrial membrane
1994 • 147 citations
Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate].
2001 • 147 citations
A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells
2003 • 147 citations
Bisphosphonates for Treatment and Prevention of Bone Metastases
2005 • 146 citations
On the effects of paraquat on isolated mitochondria. Evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide
1995 • 146 citations
Mitogen-activated protein kinase pathway-dependent tumor-specific survival signaling in melanoma cells through inactivation of the proapoptotic protein bad.
2003 • 145 citations
p21-activated Kinase 1 (Pak1)-dependent Phosphorylation of Raf-1 Regulates Its Mitochondrial Localization, Phosphorylation of BAD, and Bcl-2 Association
2005 • 145 citations
Aberrant Methylation and Silencing of theBNIP3Gene in Colorectal and Gastric Cancer
2005 • 145 citations
Mitochondriotoxic compounds for cancer therapy
2006 • 144 citations
Acetylcholine from vagal stimulation protects cardiomyocytes against ischemia and hypoxia involving additive non‐hypoxic induction of HIF‐1α
2005 • 143 citations
Tumor Necrosis Factor Induces Phosphorylation and Translocation of BAD through a Phosphatidylinositide-3-OH Kinase-dependent Pathway
1999 • 141 citations
Cadmium directly induced the opening of membrane permeability pore of mitochondria which possibly involved in cadmium-triggered apoptosis
2003 • 139 citations
Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and Apoptosis in Alzheimer’s Disease
2005 • 139 citations
Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH.
1996 • 137 citations
Protein Kinase C θ and ε Promote T-cell Survival by a Rsk-dependent Phosphorylation and Inactivation of BAD
2000 • 136 citations
Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics – an update
2005 • 136 citations
Gentamicin-induced apoptosis in LLC-PK1 cells: Involvement of lysosomes and mitochondria
2005 • 135 citations
The many shapes of mitochondrial death
2006 • 135 citations
Opening of the mitochondrial permeability transition pore causes matrix expansion and outer membrane rupture in fas-mediated hepatic apoptosis in mice
2000 • 134 citations
Pharmacological manipulation of Bcl-2 family members to control cell death
2005 • 134 citations
PB1-F2, an Influenza A Virus-Encoded Proapoptotic Mitochondrial Protein, Creates Variably Sized Pores in Planar Lipid Membranes
2004 • 133 citations
Nicotine Induces Multi-site Phosphorylation of Bad in Association with Suppression of Apoptosis
2004 • 133 citations
The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma.
2002 • 133 citations
Cyclosporin A-insensitive Permeability Transition in Brain Mitochondria
2003 • 133 citations
Targeting of the pro-apoptotic VDAC-like porin (PorB) of Neisseria gonorrhoeae to mitochondria of infected cells
2000 • 133 citations
Calcium and mitochondria: mechanisms and functions of a troubled relationship
2004 • 132 citations
Differences in the Activation of the Mitochondrial Permeability Transition Among Brain Regions in the Rat Correlate with Selective Vulnerability
1999 • 130 citations
Apoptosis of non-small-cell lung cancer cell lines after paclitaxel treatment involves the BH3-only proapoptotic protein Bim
2005 • 130 citations
c-Myb and Bcl-x Overexpression Predicts Poor Prognosis in Colorectal Cancer
2001 • 130 citations
The Hepatitis C Virus NS2 Protein Is an Inhibitor of CIDE-B-induced Apoptosis
2003 • 129 citations
The mitochondrial permeability transition: a new pathophysiological mechanism for Reye's syndrome and toxic liver injury.
1996 • 129 citations
Mitochondrial permeability transition in apoptosis and necrosis
2005 • 128 citations
The Molecular Mechanism of Noxa-induced Mitochondrial Dysfunction in p53-Mediated Cell Death
2003 • 128 citations
Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO
2004 • 128 citations
The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus.
1999 • 128 citations
Suppression of Apoptosis by Cyclophilin D via Stabilization of Hexokinase II Mitochondrial Binding in Cancer Cells
2006 • 127 citations
Effect of Cytochrome c on the Generation and Elimination of O<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.gif"><mml:msubsup><mml:mrow /><mml:mrow><mml:mn>2</mml:mn></mml:mrow><mml:mrow><mml:mo>⨪</mml:mo></mml:mrow></mml:msubsup></mml:math> and H2O2 in Mitochondria
2003 • 126 citations
New MUC1 Serum Immunoassay Differentiates Pancreatic Cancer From Pancreatitis
2005 • 126 citations
Time course and manner of Purkinje neuron death following a single ethanol exposure on postnatal day 4 in the developing rat
2002 • 126 citations
The phosphorylation status and anti‐apoptotic activity of Bcl‐2 are regulated by ERK and protein phosphatase 2A on the mitochondria
2004 • 126 citations
Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transition
2004 • 126 citations
The Peripheral Benzodiazepine Receptor: A Promising Therapeutic Drug Target
2003 • 125 citations
Processed caspase‐2 can induce mitochondria‐mediated apoptosis independently of its enzymatic activity
2004 • 125 citations
Mitochondria Play a Central Role in Estrogen-Induced Neuroprotection
2005 • 125 citations
Oxidative Stress in Mitochondria: Decision to Survival and Death of Neurons in Neurodegenerative Disorders
2005 • 125 citations
Pro-caspase-8 Is Predominantly Localized in Mitochondria and Released into Cytoplasm upon Apoptotic Stimulation
2001 • 125 citations
Bilirubin and Amyloid-β Peptide Induce Cytochrome c Release Through Mitochondrial Membrane Permeabilization
2000 • 125 citations
p53AIP1 regulates the mitochondrial apoptotic pathway.
2002 • 125 citations
Inhibition of GSK3β is a common event in neuroprotection by different survival factors
2005 • 125 citations
Tobacco-specific Nitrosamine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Promotes Functional Cooperation of Bcl2 and c-Myc through Phosphorylation in Regulating Cell Survival and Proliferation
2004 • 124 citations
Collapse of the Inner Mitochondrial Transmembrane Potential Is Not Required for Apoptosis of HL60 Cells
1999 • 124 citations
An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic Bcl-2 in human dopaminergic SH-SY5Y cells
2002 • 124 citations
An Anti-apoptotic Viral Protein That Recruits Bax to Mitochondria
2004 • 123 citations
A Central Role for Bid in Granzyme B-induced Apoptosis
2004 • 123 citations
Reversal of cisplatin resistance with a BH3 mimetic, (−)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL
2005 • 123 citations
Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077.
1996 • 123 citations
Minocycline inhibits apoptosis and inflammation in a rat model of ischemic renal injury
2004 • 122 citations
Prevention of MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) dopaminergic neurotoxicity in mice by chronic lithium: involvements of Bcl-2 and Bax
2004 • 121 citations
Cyclophilin D, a Component of the Permeability Transition-Pore, Is an Apoptosis Repressor
2004 • 121 citations
Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AIF release
2004 • 121 citations
Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane
2002 • 120 citations
Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus
2002 • 120 citations
CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation
2003 • 119 citations
The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase
2003 • 119 citations
Expression of human ANT2 gene in highly proliferative cells: GRBOX, a new transcriptional element, is involved in the regulation of glycolytic ATP import into mitochondria
1998 • 119 citations
PUMA Overexpression Induces Reactive Oxygen Species Generation and Proteasome-Mediated Stathmin Degradation in Colorectal Cancer Cells
2005 • 119 citations
Perp Is a Mediator of p53-Dependent Apoptosis in Diverse Cell Types
2003 • 118 citations
Overexpression of mitochondrial manganese superoxide dismutase protects against radiation-induced cell death in the human hepatocellular carcinoma cell line HLE.
2001 • 118 citations
Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme.
2003 • 117 citations
The dependence receptor hypothesis
2004 • 116 citations
MUC1 oncoprotein is targeted to mitochondria by heregulin-induced activation of c-Src and the molecular chaperone HSP90
2005 • 116 citations
Mitochondrial viability and apoptosis induced by aluminum, mercuric mercury and methylmercury in cell lines of neural origin
2004 • 115 citations
MAP-1 is a mitochondrial effector of Bax
2005 • 115 citations
A Role of the Mitochondrial Apoptosis-Inducing Factor in Granulysin-Induced Apoptosis
2001 • 113 citations
Trimetazidine inhibits mitochondrial permeability transition pore opening and prevents lethal ischemia–reperfusion injury
2005 • 113 citations
Lipid microdomains contribute to apoptosis-associated modifications of mitochondria in T cells
2005 • 112 citations
Bcl-2 and Bax Exert Opposing Effects on Ca2+ Signaling, Which Do Not Depend on Their Putative Pore-forming Region
2004 • 112 citations
TAT-BH4 and TAT-Bcl-xL Peptides Protect against Sepsis-Induced Lymphocyte Apoptosis In Vivo
2006 • 112 citations
Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain
2003 • 111 citations
Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell-death mediators by a Nur77-dependent pathway
2005 • 111 citations
TR3/Nur77 in colon cancer cell apoptosis.
2003 • 110 citations
Mitochondrial dysfunction is a primary event in renal cell oxalate toxicity
2004 • 110 citations
Downregulation of Smac/DIABLO Expression in Renal Cell Carcinoma and Its Prognostic Significance
2004 • 109 citations
Alterations of the Tumor Suppressor Gene Parkin in Non-Small Cell Lung Cancer
2004 • 109 citations
Bcl-2 and calcium: controversy beneath the surface
2004 • 109 citations
Protein kinase Cɛ interacts with Bax and promotes survival of human prostate cancer cells
2003 • 108 citations
Intrathecal cyclosporin prolongs survival of late-stage ALS mice
2001 • 108 citations
Bcl-2 on the endoplasmic reticulum: protecting the mitochondria from a distance
2003 • 108 citations
Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis
1999 • 108 citations
Role of p53 and reactive oxygen species in apoptotic response to copper and zinc in epithelial breast cancer cells
2005 • 108 citations
Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells
2004 • 107 citations
Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma
2005 • 107 citations
Cellular Vacuolation and Mitochondrial Cytochrome c Release Are Independent Outcomes of Helicobacter pylori Vacuolating Cytotoxin Activity That Are Each Dependent on Membrane Channel Formation
2003 • 106 citations
Cell death induced by granzyme C
2003 • 106 citations
Hypoxia-inducible factors and hypoxic cell death in tumour physiology
2004 • 106 citations
(−)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer
2005 • 104 citations
Isoenzymes of protein kinase C: differential involvement in apoptosis and pathogenesis.
1997 • 104 citations
Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD
2005 • 104 citations
Generation and Characterization of Endonuclease G Null Mice
2004 • 104 citations
The peripheral benzodiazepine receptors: a review.
2000 • 104 citations
BH4-domain peptide from Bcl-xL exerts anti-apoptotic activity in vivo
2003 • 103 citations
Bax interacts with the voltage-dependent anion channel and mediates ethanol-induced apoptosis in rat hepatocytes
2004 • 103 citations
Antiapoptotic effect of nicorandil mediated by mitochondrial atp-sensitive potassium channels in cultured cardiac myocytes
2002 • 103 citations
The Control of Endoplasmic Reticulum-Initiated Apoptosis by the BCL-2 Family of Proteins
2006 • 102 citations
Selective nitration of mitochondrial complex I by peroxynitrite: involvement in mitochondria dysfunction and cell death of dopaminergic SH-SY5Y cells
2002 • 102 citations
Mitochondrial Hexokinases: Guardians of the Mitochondria
2005 • 102 citations
Apoptosis-inducing factor determines the chemoresistance of non-small-cell lung carcinomas
2004 • 100 citations
The Myxoma Poxvirus Protein, M11L, Prevents Apoptosis by Direct Interaction with the Mitochondrial Permeability Transition Pore
2002 • 99 citations
Simplification of complex peptide mixtures for proteomic analysis: Reversible biotinylation of cysteinyl peptides
2000 • 99 citations
Bilirubin directly disrupts membrane lipid polarity and fluidity, protein order, and redox status in rat mitochondria
2002 • 99 citations
Actin Modulates the Gating of Neurospora crassa VDAC
2001 • 99 citations
FTY720 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Drug Resistance
2005 • 99 citations
Bax-dependent Regulation of Bak by Voltage-dependent Anion Channel 2
2005 • 98 citations
Expression of Mcl‐1 in mantle cell lymphoma is associated with high‐grade morphology, a high proliferative state, and p53 overexpression
2002 • 98 citations
MCL-1 expression in B-cell non-Hodgkin’s lymphomas
2004 • 97 citations
Clinically Approved Heterocyclics Act on a Mitochondrial Target and Reduce Stroke-induced Pathology
2004 • 97 citations
Proline Oxidase Induces Apoptosis in Tumor Cells, and Its Expression Is Frequently Absent or Reduced in Renal Carcinomas
2003 • 97 citations
The Vaccinia Virus F1L Protein Interacts with the Proapoptotic Protein Bak and Inhibits Bak Activation
2005 • 95 citations
Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals
2004 • 95 citations
Endonuclease G is required for early embryogenesis and normal apoptosis in mice
2003 • 95 citations
Recruitment of NF-κB into Mitochondria Is Involved in Adenine Nucleotide Translocase 1 (ANT1)-induced Apoptosis
2004 • 94 citations
Neurotoxins and neurotoxic species implicated in neurodegeneration
2004 • 94 citations
Epstein-Barr Virus BALF1 Is a BCL-2-Like Antagonist of the Herpesvirus Antiapoptotic BCL-2 Proteins
2002 • 94 citations
Maspin Mediates Increased Tumor Cell Apoptosis upon Induction of the Mitochondrial Permeability Transition
2005 • 94 citations
Mitochondrial Carrier Homolog 2 Is a Target of tBID in Cells Signaled To Die by Tumor Necrosis Factor Alpha
2005 • 93 citations
Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor
2005 • 93 citations
Protective Effect of the Xanthate, D609, on Alzheimer's Amyloid β-peptide (1–42)-induced Oxidative Stress in Primary Neuronal Cells
2004 • 93 citations
Tetrocarcin A inhibits mitochondrial functions of Bcl-2 and suppresses its anti-apoptotic activity.
2000 • 92 citations
Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and Bcl-XL
2002 • 91 citations
Identification of the Hypoxia-Inducible Factor 1α-Responsive HGTD-P Gene as a Mediator in the Mitochondrial Apoptotic Pathway
2004 • 90 citations
Proteasome Activation Occurs at an Early, Premitochondrial Step of Thymocyte Apoptosis
1998 • 90 citations
A Developmentally Regulated, Neuron-specific Splice Variant of the Variable Subunit Bβ Targets Protein Phosphatase 2A to Mitochondria and Modulates Apoptosis
2003 • 90 citations
Pharmacologically induced preconditioning with diazoxide: a novel approach to brain protection31The Thoracic Surgery Directors Association (TSDA) Resident Research Award, sponsored by Medtronic, Inc, was established in 1990 to encourage resident research in cardiothoracic surgery. Abstracts submitted to The Society of Thoracic Surgeons (STS) Program Committee representing research performed by residents were forwarded to the TSDA to be considered for this award. The abstracts were reviewed by …
2001 • 90 citations
The Biochemistry and Toxicity of Atractyloside: A Review
2000 • 88 citations
Manganese-induced rat pheochromocytoma (PC12) cell death is independent of caspase activation
2000 • 87 citations
A Pool of Extramitochondrial Frataxin That Promotes Cell Survival
2006 • 87 citations
Screening Assays for the Mitochondrial Permeability Transition Using a Fluorescence Multiwell Plate Reader
2001 • 87 citations
Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer
2005 • 87 citations
DNA Methylation Is Required for Silencing of Ant4 , an Adenine Nucleotide Translocase Selectively Expressed in Mouse Embryonic Stem Cells and Germ Cells
2005 • 87 citations
Dynamic evolution of the adenine nucleotide translocase interactome during chemotherapy-induced apoptosis
2004 • 86 citations
Opening of Mitochondrial K ATP Channels Attenuates the Ouabain-Induced Calcium Overload in Mitochondria
2001 • 86 citations
PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor
2005 • 86 citations
Solution Structure of the BHRF1 Protein From Epstein-Barr Virus, a Homolog of Human Bcl-2
2003 • 86 citations
Myxoma Virus M11L Prevents Apoptosis through Constitutive Interaction with Bak
2004 • 86 citations
The hepatitis B virus X protein abrogates Bcl-2-mediated protection against Fas apoptosis in the liver
2002 • 85 citations
IκB-α, the NF-κB Inhibitory Subunit, Interacts with ANT, the Mitochondrial ATP/ADP Translocator
2001 • 85 citations
Protection of NRK-52E Cells, a Rat Renal Proximal Tubular Cell Line, from Chemical-Induced Apoptosis by Overexpression of a Mitochondrial Glutathione Transporter
2002 • 85 citations
Cyclosporin A prevents calpain activation despite increased intracellular calcium concentrations, as well as translocation of apoptosis‐inducing factor, cytochrome c and caspase‐3 activation in neurons exposed to transient hypoglycemia
2003 • 85 citations
Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins
2005 • 84 citations
Characterization of porin isoforms expressed in tumor cells
2000 • 84 citations
Tumor-suppressive Maspin Regulates Cell Response to Oxidative Stress by Direct Interaction with Glutathione S-Transferase
2005 • 84 citations
Metallothionein Attenuates 3-Morpholinosydnonimine (SIN-1)-Induced Oxidative Stress in Dopaminergic Neurons
2003 • 84 citations
The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family
2003 • 84 citations
A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid
2002 • 83 citations
Gangliosides as apoptotic signals in ER stress response
2006 • 83 citations
Significance of apoptosis and its relationship to antioxidants after ochratoxin A administration in mice.
2001 • 83 citations
Ochratoxin A Induces Apoptosis in Human Lymphocytes through Down Regulation of Bcl-xL
2004 • 83 citations
Ceramide Promotes Apoptosis in Lung Cancer-Derived A549 Cells by a Mechanism Involving c-Jun NH2-Terminal Kinase
2004 • 83 citations
Helicobacter pyloriInduces Apoptosis of Macrophages in Association with Alterations in the Mitochondrial Pathway
2004 • 82 citations
Bcl-2 Inhibitors Sensitize Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis by Uncoupling of Mitochondrial Respiration in Human Leukemic CEM Cells
2004 • 82 citations
tcBid promotes Ca2+ signal propagation to the mitochondria: control of Ca2+ permeation through the outer mitochondrial membrane
2002 • 81 citations
Siva-1 binds to and inhibits BCL-XL-mediated protection against UV radiation-induced apoptosis
2002 • 81 citations
Expression of heat shock protein (Hsp) 70 and Hsp 40 in gastric cancer
2003 • 81 citations
Oxidative stress and apoptosis in fetal rat liver induced by maternal cholestasis. Protective effect of ursodeoxycholic acid
2005 • 81 citations
Caspase cleavage of Bim EL triggers a positive feedback amplification of apoptotic signaling
2004 • 81 citations
Development of Beta-Amyloid-induced Neurodegeneration in Alzheimer's Disease and Novel Neuroprotective Strategies
2005 • 81 citations
Redundant cell death mechanisms as relics and backups
2005 • 80 citations
Functional Properties of Recombinant Type I and Type III Inositol 1,4,5-Trisphosphate Receptor Isoforms Expressed in COS-7 Cells
2000 • 80 citations
Valproic acid‐mediated Hsp70 induction and anti‐apoptotic neuroprotection in SH‐SY5Y cells
2005 • 80 citations
Neisserial PorB is translocated to the mitochondria of HeLa cells infected with Neisseria meningitidis and protects cells from apoptosis
2003 • 80 citations
The Proapoptotic Gene SIVA Is a Direct Transcriptional Target for the Tumor Suppressors p53 and E2F1
2004 • 80 citations
Induction of apoptosis by the transactivating domains of the hepatitis B virus X gene leads to suppression of oncogenic transformation of primary rat embryo fibroblasts
2000 • 79 citations
p53's believe it or not: lessons on transcription-independent death.
2003 • 79 citations
Human Immunodeficiency Virus Type 1 Vpr Interacts with Antiapoptotic Mitochondrial Protein HAX-1
2005 • 79 citations
The permeability transition pore triggers Bax translocation to mitochondria during neuronal apoptosis
2005 • 79 citations
Prognostic Significance of Bax Protein Expression in Diffuse Aggressive Non-Hodgkin's Lymphoma
1997 • 79 citations
Palmitate induces apoptosis via a direct effect on mitochondria.
1999 • 79 citations
The Amino-Terminal Region of Vpr from Human Immunodeficiency Virus Type 1 Forms Ion Channels and Kills Neurons
1999 • 79 citations
Oxidative Stress Is Responsible for Mitochondrial Permeability Transition Induction by Salicylate in Liver Mitochondria
2005 • 79 citations
Apoptosis And Calcium: New Roles For Cytochrome c and Inositol 1,4,5-trisphosphate
2004 • 78 citations
Inhibition of Bax-Induced CytochromecRelease from Neural Cell and Brain Mitochondria by Dibucaine and Propranolol
2003 • 78 citations
Apoptosis and the Heart
1997 • 78 citations
Bcl-XL Mutations Suppress Cellular Sensitivity to Antimycin A
2004 • 78 citations
Effects of fatty acids in isolated mitochondria: implications for ischemic injury and cardioprotection
2003 • 77 citations
Activation of Src kinase Lyn by the Kaposi sarcoma–associated herpesvirus K1 protein: implications for lymphomagenesis
2005 • 77 citations
FTY720, a fungus metabolite, inhibits in vivo growth of androgen‐independent prostate cancer
2005 • 77 citations
Lysosomes and endoplasmic reticulum: Targets for improved, selective anticancer therapy
2005 • 77 citations
BimEL up‐regulation potentiates AIF translocation and cell death in response to MPTP
2005 • 77 citations
Apoptosis induction by the photosensitizer verteporfin: identification of mitochondrial adenine nucleotide translocator as a critical target.
2001 • 77 citations
Copper-dependent toxicity in SH-SY5Y neuroblastoma cells involves mitochondrial damage
2004 • 77 citations
Trimetazidine counteracts the hepatic injury associated with ischemia-reperfusion by preserving mitochondrial function.
1998 • 76 citations
Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer.
2003 • 76 citations
1-Methyl-4-phenyl-pyridinium ion (MPP+) causes DNA fragmentation and increases the Bcl-2 expression in human neuroblastoma, SH-SY5Y cells, through different mechanisms
1995 • 76 citations
Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32
2004 • 75 citations
E2 of Hepatitis C Virus Inhibits Apoptosis
2005 • 75 citations
Zinc pyrithione induces apoptosis and increases expression of Bim
2005 • 75 citations
Blockade of Calcium Influx through L-Type Calcium Channels Attenuates Mitochondrial Injury and Apoptosis in Hypoxic Renal Tubular Cells
2004 • 75 citations
F16, a Mitochondriotoxic Compound, Triggers Apoptosis or Necrosis Depending on the Genetic Background of the Target Carcinoma Cell
2004 • 74 citations
Neuroprotection by cyclosporin A following transient brain ischemia correlates with the inhibition of the early efflux of cytochrome C to cytoplasm
2004 • 74 citations
Inhibition of Translation and Induction of Apoptosis by Bunyaviral Nonstructural Proteins Bearing Sequence Similarity to Reaper
2003 • 74 citations
Analysis of Functional Coupling: Mitochondrial Creatine Kinase and Adenine Nucleotide Translocase
2004 • 74 citations
Bax Does Not Directly Participate in the Ca2+-induced Permeability Transition of Isolated Mitochondria
2004 • 73 citations
Combined GADD45A and Thymidine Phosphorylase Expression Levels Predict Response and Survival of Neoadjuvant-Treated Gastric Cancer Patients
2005 • 73 citations
Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands
2004 • 73 citations
Ultrastructural localization of BHRF1: an Epstein-Barr virus gene product which has homology with bcl-2.
1994 • 72 citations
P53 Mediates Amosite Asbestos–Induced Alveolar Epithelial Cell Mitochondria-Regulated Apoptosis
2005 • 72 citations
Caspase- and mitochondrial dysfunction-dependent mechanisms of lysosomal leakage and cathepsin B activation in DNA damage-induced apoptosis
2005 • 71 citations
Dimerization and Processing of Procaspase-9 by Redox Stress in Mitochondria
2004 • 71 citations
Inactivating mutations of proapoptotic Bad gene in human colon cancers
2004 • 71 citations
Disruption of Mcl-1·Bim Complex in Granzyme B-mediated Mitochondrial Apoptosis
2005 • 71 citations
Suppression of tumor growth and cell proliferation by p13 II , a mitochondrial protein of human T cell leukemia virus type 1
2004 • 70 citations
Newcomers in the process of mitochondrial permeabilization
2005 • 70 citations
Up-regulation of the proapoptotic mediators Bax and Bak after adenovirus-mediated p53 gene transfer in lung cancer cells.
2000 • 70 citations
Exogenous Bcl‐xl fusion protein spares neurons after spinal cord injury
2005 • 70 citations
Blockade of Epidermal Growth Factor Receptors Chemosensitizes Breast Cancer Cells through Up-Regulation of Bnip3L
2005 • 70 citations
K ATP Channel Gene Expression Is Induced by Urocortin and Mediates Its Cardioprotective Effect
2002 • 70 citations
The therapeutic role of creatine in Huntington's disease
2005 • 70 citations
Induction of apoptosis and chemosensitization of mesothelioma cells by Bcl‐2 and Bcl‐xL antisense treatment
2003 • 70 citations
Attenuation of liver normothermic ischemia-reperfusion injury by preservation of mitochondrial functions with S-15176, a potent trimetazidine derivative11Abbreviations: ASAT, aspartate aminotransferase; ALAT, alanine aminotransferase; PTP, permeability transition pore; RCR, respiratory control ratio; ROS, reactive oxygen species; and ΔΨ, mitochondrial membrane potential.
2001 • 70 citations
Apoptin-induced cell death is modulated by Bcl-2 family members and is Apaf-1 dependent
2005 • 70 citations
The Mitochondrial Effects of Small Organic Ligands of BCL-2
2006 • 69 citations
Mitochondrial Pathway Is Responsible for Aging-Related Increase of Tubular Cell Apoptosis in Renal Ischemia/Reperfusion Injury
2005 • 69 citations
Protein synthesis persists during necrotic cell death
2005 • 69 citations
Protective Effect of Harmalol and Harmaline on MPTP Neurotoxicity in the Mouse and Dopamine‐Induced Damage of Brain Mitochondria and PC12 Cells
2000 • 69 citations
General Auditory Processes Contribute to Perceptual Accommodation of Coarticulation
2000 • 68 citations
Hepatitis B virus X protein induces apoptosis in hepatoma cells through inhibiting Bcl-xL expression
2005 • 68 citations
The increase in mitochondrial association with actin precedes Bax translocation in apoptosis
2006 • 68 citations
Death-associated Protein 3 Localizes to the Mitochondria and Is Involved in the Process of Mitochondrial Fragmentation during Cell Death
2004 • 68 citations
Novel Neuroprotective Mechanism of Action of Rasagiline Is Associated with Its Propargyl Moiety: Interaction of Bcl‐2 Family Members with PKC Pathway
2005 • 68 citations
Geldanamycin induces mitotic catastrophe and subsequent apoptosis in human glioma cells
2004 • 67 citations
Expression of oxidative phosphorylation genes in renal tumors and tumoral cell lines
1996 • 67 citations
VDAC Channels Differentiate between Natural Metabolites and Synthetic Molecules
2002 • 67 citations
l-Carnitine suppresses the onset of neuromuscular degeneration and increases the life span of mice with familial amyotrophic lateral sclerosis
2006 • 66 citations
An ALS mouse model with a permeable blood–brain barrier benefits from systemic cyclosporine A treatment
2004 • 66 citations
Ubiquitous mitochondrial creatine kinase downregulated in oral squamous cell carcinoma
2006 • 66 citations
Resveratrol-induced apoptosis is enhanced in acute lymphoblastic leukemia cells by modulation of the mitochondrial permeability transition pore
2005 • 65 citations
Hydrophilic bile salt ursodeoxycholic acid protects myocardium against reperfusion injury in a PI3K/Akt dependent pathway
2005 • 65 citations
Toxicity of hepatotoxins: new insights into mechanisms and therapy
1999 • 65 citations
Negative regulation of mitochondrial VDAC channels by C-Raf kinase.
2002 • 65 citations
Presenilin mutations and calcium signaling defects in the nervous and immune systems
2001 • 65 citations
Prolonged, But Not Acute, Glutathione Depletion Promotes Fas–Mediated Mitochondrial Permeability Transition and Apoptosis in Mice
2001 • 65 citations
Relationships between the NAD(P) redox state, fatty acid oxidation, and inner membrane permeability in rat liver mitochondria
1989 • 65 citations
Molecular Mechanisms of Hexavalent Chromium–Induced Apoptosis in Human Bronchoalveolar Cells
2005 • 65 citations
Vasculoprotective effect of insulin in the ischemic/reperfused canine heart: Role of Akt-stimulated NO production
2005 • 64 citations
Pivotal role of Harakiri in the induction and prevention of gentamicin-induced hearing loss
2005 • 64 citations
Vaccinia Virus F1L Protein Is a Tail-Anchored Protein That Functions at the Mitochondria To Inhibit Apoptosis
2004 • 64 citations
Combined p53/Bax mutation results in extremely poor prognosis in gastric carcinoma with low microsatellite instability
2003 • 63 citations
Cytochrome c release from rat brain mitochondria is proportional to the mitochondrial functional deficit: implications for apoptosis and neurodegenerative disease
2005 • 63 citations
Modulation of cell calcium signals by mitochondria.
1998 • 62 citations
Bcl-w is expressed in a majority of infiltrative gastric adenocarcinomas and suppresses the cancer cell death by blocking stress-activated protein kinase/c-Jun NH2-terminal kinase activation.
2003 • 62 citations
Mechanism of toxicity of the branched‐chain fatty acid phytanic acid, a marker of Refsum disease, in astrocytes involves mitochondrial impairment
2006 • 62 citations
Liposome-mediated transfer of the bcl-2 gene results in neuroprotection after in vivo transient focal cerebral ischemia in an animal model
2002 • 62 citations
The Bile Acid Tauroursodeoxycholic Acid Modulates Phosphorylation and Translocation of Bad via Phosphatidylinositol 3-Kinase in Glutamate-Induced Apoptosis of Rat Cortical Neurons
2004 • 61 citations
Cytochrome c release precedes mitochondrial membrane potential loss in cerebellar granule neuron apoptosis: lack of mitochondrial swelling
2002 • 61 citations
Heat shock protein-90, IL-6 and IL-10 in bladder cancer.
2001 • 60 citations
Mercuric chloride induces apoptosis via a mitochondrial-dependent pathway in human leukemia cells
2002 • 60 citations
Iron toxicity in organotypic cultures of hippocampal slices: role of reactive oxygen species
2003 • 60 citations
Drugs of Abuse Induce Apoptotic Features in PC12 Cells
2003 • 60 citations
Early resistance to cell death and to onset of the mitochondrial permeability transition during hepatocarcinogenesis with 2-acetylaminofluorene
2003 • 60 citations
Death of cortical and striatal neurons induced by mitochondrial defect involves differential molecular mechanisms
2003 • 59 citations
Mitochondrial permeability transition as a novel principle of hepatorenal toxicity in vivo.
2002 • 58 citations
Nitric oxide-induced carbonylation of Bcl-2, GAPDH and ANT precedes apoptotic events in insulin-secreting RINm5F cells
2003 • 58 citations
The intrinsic mitochondrial membrane potential (Deltapsim) is associated with steady-state mitochondrial activity and the extent to which colonic epithelial cells undergo butyrate-mediated growth arrest and apoptosis.
2003 • 58 citations
Creatine kinase activity and isoenzyme pattern in various normal tissues and neoplasms.
1983 • 57 citations
Inactivating mutation of the pro‐apoptotic gene BID in gastric cancer
2004 • 57 citations
Mitochondria as Targets of Apoptosis Regulation by Nitric Oxide
2003 • 57 citations
Minocycline attenuates gentamicin induced hair cell loss in neonatal cochlear cultures
2004 • 57 citations
Induction of free radicals in hepatocytes, mitochondria and microsomes of rats by ochratoxin A and its analogs
1997 • 57 citations
Mitochondria as Functional Targets of Proteins Coded by Human Tumor Viruses
2005 • 57 citations
(−)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-XL-mediated apoptosis resistance
2005 • 56 citations
Heat shock protein 90 suppresses tumor necrosis factor alpha induced apoptosis by preventing the cleavage of Bid in NIH3T3 fibroblasts
2003 • 56 citations
Cocaine-induced changes in the expression of apoptosis-related genes in the fetal mouse cerebral wall
2004 • 55 citations
AMID is a p53-inducible gene downregulated in tumors
2004 • 55 citations
Caspase activation and apoptosis in response to proteasome inhibitors
2005 • 55 citations
Physical interaction of apoptosis-inducing factor with DNA and RNA
2005 • 55 citations
Abrogation of the Cell Death Response to Oxidative Stress by the c-Abl Tyrosine Kinase Inhibitor STI571
2003 • 55 citations
Expression and regulation of tumor suppressor gene maspin in human bladder cancer
2003 • 54 citations
Dose-dependent Mercuric Chloride Tubular Injury in Rat Kidney
2003 • 54 citations
Morphologic and functional alterations induced by low doses of mercuric chloride in the kidney OK cell line: ultrastructural evidence for an apoptotic mechanism of damage
2005 • 54 citations
Nicorandil inhibits oxidative stress-induced apoptosis in cardiac myocytes through activation of mitochondrial ATP-sensitive potassium channels and a nitrate-like effect
2003 • 54 citations
A Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Hormone-Refractory Metastatic Prostate Cancer
2005 • 53 citations
Characterization of the mitochondrial association of hepatitis B virus X protein, HBx
2002 • 53 citations
The flexible loop of Bcl‐2 is required for molecular interaction with immunosuppressant FK‐506 binding protein 38 (FKBP38)
2005 • 53 citations
VDAC and peripheral channelling complexes in health and disease
2003 • 53 citations
Coenzyme Q10 inhibits mitochondrial complex‐1 down‐regulation and nuclear factor‐kappa B activation
2004 • 52 citations
[18F]Fluorodeoxyglucose Uptake in Recurrent Thyroid Cancer Is Related to Hexokinase I Expression in the Primary Tumor
2005 • 52 citations
The serine protease Omi/HtrA2: a second mammalian protein with a Reaper-like function
2002 • 52 citations
Role of Mitochondrial Dysfunction in S-(1,2-Dichlorovinyl)-l-cysteine-Induced Apoptosis
2001 • 52 citations
Cyclosporin-A reduces leukocyte accumulation and protects against myocardial ischaemia reperfusion injury in rats
1999 • 52 citations
Adeno-Associated Virus 2-Mediated Intratumoral Prostate Cancer Gene Therapy: Long-Term Maspin Expression Efficiently Suppresses Tumor Growth
2005 • 51 citations
Fraxetin prevents rotenone-induced apoptosis by induction of endogenous glutathione in human neuroblastoma cells
2005 • 51 citations
Novel Neuroprotective Mechanism of Action of Rasagiline Is Associated with Its Propargyl Moiety: Interaction of Bcl-2 Family Members with PKC Pathway
2005 • 51 citations
Protective effect of serotonin on 6-hydroxydopamine- and dopamine-induced oxidative damage of brain mitochondria and synaptosomes and PC12 cells
2002 • 50 citations
Caffeic acid phenethyl ester possesses potent cardioprotective effects in a rabbit model of acute myocardial ischemia-reperfusion injury
2005 • 50 citations
JNK activation contributes to DP5 induction and apoptosis following traumatic spinal cord injury
2005 • 49 citations
Modulation of Expression of Rat Mitochondrial 2-Oxoglutarate Carrier in NRK-52E Cells Alters Mitochondrial Transport and Accumulation of Glutathione and Susceptibility to Chemically Induced Apoptosis
2005 • 49 citations
Bak but not Bax is essential for Bcl-xS-induced apoptosis
2005 • 49 citations
Purified Photoproducts of Merocyanine 540 Trigger Cytochrome C Release and Caspase 8-Dependent Apoptosis in Human Leukemia and Melanoma Cells
1999 • 48 citations
Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) γ2 gene expression in brown adipocytes: intracellular signalling and effects on PPARγ2 and PPARγ1 protein levels
2004 • 48 citations
Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway
2004 • 47 citations
Proteasome activation as a critical event of thymocyte apoptosis
2000 • 47 citations
Mitochondrial localization of p53 during adenovirus infection and regulation of its activity by E1B-19K
2005 • 47 citations
Hepatocyte Lysis Induced by Environmental Metal Toxins May Involve Apoptotic Death Signals Initiated by Mitochondrial Injury
2001 • 47 citations
The Mitochondrial Permeability Transition as a Target for Neuroprotection
2004 • 46 citations
Differential expression of Janus kinase 3 (JAK3), matrix metalloproteinase 13 (MMP13), heat shock protein 60 (HSP60), and mouse double minute 2 (MDM2) in human colorectal cancer progression using human cancer cDNA microarrays
2005 • 46 citations
Expression of Heat Shock Protein (Hsp) 70 and Hsp 40 in Colorectal Cancer
2003 • 46 citations
Hypothermia causes a marked injury to rat proximal tubular cells that is aggravated by all currently used preservation solutions
2003 • 46 citations
The BH3 Domain of Bcl-xS Is Required for Inhibition of the Antiapoptotic Function of Bcl-xL
1999 • 46 citations
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1998 • 45 citations
Prevention of cytosolic IAPs degradation: a potential pharmacological target in Huntington's Disease
2005 • 44 citations
Bcl-2 antisense therapy in B-cell malignancies
2005 • 44 citations
Functional promoter upstream p53 regulatory sequence of IGFBP3 that is silenced by tumor specific methylation
2005 • 44 citations
Glycogen Synthase Kinase-3 Mediates Acetaminophen-Induced Apoptosis in Human Hepatoma Cells
2005 • 43 citations
Protective Effect of Amiodarone but NotN-Desethylamiodarone on Postischemic Hearts through the Inhibition of Mitochondrial Permeability Transition
2003 • 43 citations
Cadmium Toxicity toward Caspase‐Independent Apoptosis through the Mitochondria‐Calcium Pathway in mtDNA‐Depleted Cells
2005 • 42 citations
Mitochondrial permeability transition and cytochrome c release in ischemia-reperfusion injury of the rat liver
2003 • 42 citations
p53 in apoptosis control: An introduction
2005 • 41 citations
Up-Regulation of the Peripheral Benzodiazepine Receptor during Human Colorectal Carcinogenesis and Tumor Spread
2005 • 40 citations
In vivo cerebrovascular actions of amyloid β-peptides and the protective effect of conjugated estrogens
2003 • 40 citations
BH4 peptide derivative from Bcl-xL attenuates ischemia/reperfusion injury thorough anti-apoptotic mechanism in rat hearts
2004 • 40 citations
Mitochondria determine the survival and death in apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, and neuroprotection by propargylamines
2002 • 39 citations
Met/HGF receptor modulates bcl-w expression and inhibits apoptosis in human colorectal cancers
2000 • 39 citations
Preconditioning with Sodium Arsenite Inhibits Apoptotic Cell Death in Rat Kidney with Ischemia/Reperfusion or Cyclosporine-Induced Injuries
2001 • 38 citations
Mitochondrial membrane permeabilization by HIV-1 Vpr
2004 • 37 citations
Bcl-xES, a BH4- and BH2-containing antiapoptotic protein, delays Bax oligomer formation and binds Apaf-1, blocking procaspase-9 activation
2004 • 37 citations
The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth
2005 • 37 citations
Expression of a novel Bcl-2 related gene, Bfl-1, in various human cancers and cancer cell lines.
1998 • 37 citations
Analysis of the candidate 8p21 tumour suppressor, BNIP3L, in breast and ovarian cancer
2003 • 37 citations
Protective effect of L-carnitine on renal ischaemia-reperfusion injury in the rat
2004 • 37 citations
N-methylated β-carbolines protect PC12 cells from cytotoxic effect of MPP+ by attenuation of mitochondrial membrane permeability change
2003 • 37 citations
Early steps in bilirubin‐mediated apoptosis in murine hepatoma (Hepa 1c1c7) cells are characterized by aryl hydrocarbon receptor‐independent oxidative stress and activation of the mitochondrial pathway
2005 • 36 citations
Glucose Uptake and Adenoviral Mediated GLUT1 Infection Decrease Hypoxia-induced HIF-1α Levels in Cardiac Myocytes
2002 • 36 citations
Avian encephalomyelitis virus nonstructural protein 2C induces apoptosis by activating cytochrome c /caspase-9 pathway
2003 • 36 citations
Binding characteristics of SSR180575, a potent and selective peripheral benzodiazepine ligand
2003 • 35 citations
Interaction between the HIV‐1 Protein Vpr and the Adenine Nucleotide Translocator
2006 • 35 citations
RT-PCR determination of maspin and mammaglobin B in peripheral blood of healthy donors and breast cancer patients
2005 • 35 citations
Warm blood cardioplegic arrest induces mitochondrial-mediated cardiomyocyte apoptosis associated with increased urocortin expression in viable cells
2004 • 34 citations
Reduced Expression of Insulin-Like Growth Factor-Binding Protein-3 (IGFBP-3) in Squamous Cell Carcinoma Complicating Recessive Dystrophic Epidermolysis Bullosa
2004 • 34 citations
Effects of L-carnitine and its derivatives on postischemic cardiac function, ventricular fibrillation and necrotic and apoptotic cardiomyocyte death in isolated rat hearts.
2003 • 34 citations
Group IIIA-metal hydroxides indirectly neutralize the voltage sensor of the voltage-dependent mitochondrial channel, VDAC, by interacting with a dynamic binding site
1990 • 34 citations
Membrane structural changes support the involvement of mitochondria in the bile salt-induced apoptosis of rat hepatocytes
2002 • 34 citations
Delayed preconditioning of the human myocardium: signal transduction and clinical implications
2003 • 34 citations
Induction of p53‐independent apoptosis by the BH3‐only protein ITM2Bs
2004 • 33 citations
Methylation-induced silencing of ASC and the effect of expressed ASC on p53-mediated chemosensitivity in colorectal cancer
2005 • 33 citations
PUMA in head and neck cancer
2003 • 33 citations
Mitochondrial membrane potentials in ischemic hearts
2003 • 33 citations
Alternating metabolic pathways in NGF-deprived sympathetic neurons affect caspase-independent death
2003 • 33 citations
Potential of Sanguiin H-6 against Oxidative Damage in Renal Mitochondria and Apoptosis Mediated by Peroxynitrite in vivo
2002 • 32 citations
Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3
2005 • 32 citations
Liver delivery of NO by NCX‐1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice THIS ARTICLE HAS BEEN RETRACTED
2004 • 32 citations
MKT-077, localized lipophilic cation: antitumor activity against human tumor xenografts serially transplanted into nude mice.
1998 • 32 citations
Acidic pH inhibits ATP depletion-induced tubular cell apoptosis by blocking caspase-9 activation in apoptosome
2005 • 32 citations
High Throughput Fluorescence Assays for the Measurement of Mitochondrial Activity in Intact Human Neuroblastoma Cells
2001 • 31 citations
Mitochondrial Glutathione and Chemically Induced Stress Including Ethanol
2004 • 31 citations
Transcriptional regulation of the human transferrin gene by GADD153 in hepatoma cells
2003 • 31 citations
A Retinoid-Related Molecule that Does Not Bind to Classical Retinoid Receptors Potently Induces Apoptosis in Human Prostate Cancer Cells through Rapid Caspase Activation
2004 • 31 citations
Viral modulators of cell death provide new links to old pathways
2003 • 30 citations
Cyclosporin A pretreatment in a rat model of warm ischaemia/reperfusion injury
2002 • 30 citations
Protection of mitochondrial integrity from oxidative stress by the triaminopyridine derivative flupirtine
2000 • 30 citations
Ursodeoxycholate protects against ethanol-induced liver mitochondrial injury
1998 • 30 citations
The E2F-1 Transcription Factor Promotes Caspase-8 and Bid Expression, and Enhances Fas Signaling in T Cells
2004 • 29 citations
Neuroprotective effect of l-carnitine in the 3-nitropropionic acid (3-NPA)-evoked neurotoxicity in rats
2004 • 29 citations
The human mitochondrial transport protein family: Identification and protein regions significant for transport function and substrate specificity
2005 • 29 citations
TRIMETAZIDINE AMELIORATES THE HEPATIC INJURY ASSOCIATED WITH ISCHAEMIA–REPERFUSION IN RATS
1999 • 29 citations
Noxa in colorectal cancer: a study on DNA, mRNA and protein expression
2003 • 29 citations
Ferredoxin reductase: pharmacogenomic assessment in colorectal cancer.
2003 • 28 citations
Therapeutic peptides: Targeting the mitochondrion to modulate apoptosis
2006 • 28 citations
Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant
2005 • 28 citations
Gemcitabine Plus Paclitaxel in Breast Cancer
2005 • 28 citations
Down-regulation of apoptosis-inducing factor protein by RNA interference inhibits UVA-induced cell death
2004 • 27 citations
Mitochondrial KATP channel opener prevents ischemia-reperfusion injury in rat liver
2005 • 27 citations
Inhibition of cell proliferation and induction of apoptosis by Helicobacter pylori through increased phosphorylated p53, p21 and Bax expression in endothelial cells
2002 • 27 citations
Monogene and Polygene Therapy for the Treatment of Experimental Prostate Cancers by Use of Apoptotic Genes bax and bad Driven by the Prostate-Specific Promoter ARR2PB
2002 • 26 citations
Inhibition of apoptosis by Zn2+in renal tubular cells following ATP depletion
2004 • 26 citations
CD437, a synthetic retinoid, induces apoptosis in human respiratory epithelial cells via caspase-independent mitochondrial and caspase-8-dependent pathways both up-regulated by JNK signaling pathway
2005 • 26 citations
Effects of permeability transition inhibition and decrease in cytochrome c content on doxorubicin toxicity in K562 cells
2005 • 26 citations
BH3‐domain mimetic compound BH3I‐2′ induces rapid damage to the inner mitochondrial membrane prior to the cytochrome c release from mitochondria
2003 • 26 citations
Role of mitochondrial KATP channels and protein kinase C in ischaemic preconditioning
2003 • 25 citations
A mechanism for the proapoptotic activity of ursodeoxycholic acid: effects on Bcl-2 conformation
2004 • 25 citations
The effect of ursodeoxycholic acid on glycochenodeoxycholic acid-induced apoptosis in rat hepatocytes
2005 • 24 citations
Involvement of apoptosis and calcium mobilization in tetrahydrobiopterin-induced dopaminergic cell death
2003 • 24 citations
Saturated glucose uptake capacity and impaired fatty acid oxidation in hypertensive hearts before development of heart failure
2004 • 24 citations
Expression of Two Type II-Like Tumor Hexokinase RNA Transcripts in Cancer Cell Lines
1998 • 23 citations
Insights into the mitochondrial signaling pathway: what lessons for chemotherapy?
2003 • 23 citations
N-Benzyladriamycin-14-Valerate (AD198) Induces Apoptosis through Protein Kinase C-δ–Induced Phosphorylation of Phospholipid Scramblase 3
2005 • 22 citations
Adaptations and Deficits in the Vestibulo‐Ocular Reflex after Peripheral Ocular Motor Palsies
2003 • 22 citations
RETRACTED: Cyclosporin A inhibits Al-induced cytochrome c release from mitochondria in aged rabbits
2001 • 21 citations
Mechanisms of cell death in Alzheimer's disease: Role of presenilins
2004 • 21 citations
Cyclosporin A reduces delayed motor neuron death after spinal cord ischemia in rabbits
2003 • 21 citations
Cell death in Parkinson's disease
2002 • 21 citations
Protective Activity of (−)-Epicatechin 3- O -gallate against Peroxynitrite-mediated Renal Damage
2003 • 20 citations
Herpesvirus papio encodes a functional homologue of the Epstein–Barr virus apoptosis suppressor, BHRF1
2000 • 20 citations
Chemical modification of the mitochondrial ornithine/citrulline carrier by SH reagents: effects on the transport activity and transition from carrier to pore-like function
2003 • 20 citations
Diltiazem during reperfusion preserves high energy phosphates by protection of mitochondrial integrity
2002 • 20 citations
Modulation of apoptotic regulatory proteins and early activation of cytochrome C following systemic 3-nitropropionic acid administration
2002 • 20 citations
Expression of Bfl-1 in normal and tumor tissues: Bfl-1 overexpression in cancer is attributable to its preferential expression in infiltrating inflammatory cells
1998 • 20 citations
Release of Cytochrome c from Isolated Mitochondria by Etoposide
2005 • 19 citations
Mutational analysis of Noxa gene in human cancers
2003 • 19 citations
β-Carbolines induce apoptosis in cultured cerebellar granule neurons via the mitochondrial pathway
2004 • 19 citations
Differential responses of Mcl-1 in photosensitized epithelial vs lymphoid-derived human cancer cells
2005 • 19 citations
Extracellular Bad fused to toxin transport domains induces apoptosis.
2002 • 19 citations
Baculovirus P35 inhibits NO-induced apoptosis in activated macrophages by inhibiting cytochrome c release
2004 • 19 citations
Adenovirus‐mediated p53AIP1 gene transfer as a new strategy for treatment of p53‐resistant tumors
2004 • 18 citations
Diltiazem Reduces Apoptosis in Rat Hepatocytes Subjected to Warm Hypoxia-Reoxygenation
2002 • 18 citations
Developmental Regulation of p66Shc Is Altered by Bronchopulmonary Dysplasia in Baboons and Humans
2005 • 17 citations
DLPC ATTENUATES ALCOHOL-INDUCED CYTOTOXICITY IN HEPG2 CELLS EXPRESSING CYP2E1
2005 • 17 citations
Effects of beta-aescin on apoptosis induced by transient focal cerebral ischemia in rats.
2004 • 17 citations
Attenuation of methamphetamine induced dopaminergic neurotoxicity by flupirtine: microdialysis study on dopamine release and free radical generation
2003 • 17 citations
New insights into the mechanisms involved in renal proximal tubular damage induced in vitro by ochratoxin A
2004 • 15 citations
Cardiac Toxic Effects of Trans-2-Hexenal Are Mediated by Induction of Cardiomyocyte Apoptotic Pathways
2003 • 15 citations
Protective effects of diltiazem and ryanodine against ischemia-reperfusion injury in neonatal rabbit hearts
1993 • 13 citations
Genetic alterations in the coding region of the bak gene in uterine cervical carcinoma
2003 • 13 citations
Diazoxide and Nω-nitro-L-arginine counteracted Aβ1-42-induced cytotoxicity
2004 • 12 citations
mRNA and protein expression of PUMA in sporadic colorectal cancer
2004 • 12 citations
A Chimeric Protein Induces Tumor Cell Apoptosis by Delivering the Human Bcl-2 Family BH3-Only Protein Bad
2005 • 11 citations
Peptido-Targeting of the Mitochondrial Transition Pore Complex for Therapeutic Apoptosis Induction
2006 • 11 citations
Molecular basis of morphological changes in mitochondrial membrane accompanying induction of permeability transition, as revealed by immuno-electron microscopy
2005 • 11 citations
Mutational analysis of the BAK gene in 192 advanced gastric and colorectal cancers
2004 • 11 citations
Enhancement of radiation sensitivity with BH3I-1 in non-small cell lung cancer.
2005 • 9 citations
Herpesvirus pan encodes a functional homologue of BHRF1, the Epstein-Barr virus v-Bcl-2.
2005 • 9 citations
Functional Imaging of Mitochondria Within Cells
2001 • 7 citations
Folding and binding — new technologies and new perspectives
2003 • 6 citations
The effect of Cyclosporine A on survival time in salicylate-poisoned rats
2004 • 5 citations
Deleted Work
1955 • 0 citations
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