STAT-1 Interacts with p53 to Enhance DNA Damage-induced Apoptosis

p53 Mutations in Human Cancers

1991 • 8,133 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

Live or let die: the cell's response to p53

2002 • 3,138 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

2000 • 2,064 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1995 • 1,401 citations

Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice

1998 • 1,400 citations

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

1995 • 1,114 citations

The roles of IFNγ in protection against tumor development and cancer immunoediting

2002 • 852 citations

Cell Growth Arrest and Induction of Cyclin-Dependent Kinase Inhibitor p21 ^WAF1/CIP1 Mediated by STAT1

1996 • 796 citations

Binding and modulation of p53 by p300/CBP coactivators

1997 • 698 citations

ASPP Proteins Specifically Stimulate the Apoptotic Function of p53

2001 • 656 citations

Defective TNF-α-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases

1997 • 508 citations

Two contact regions between Stat1 and CBP/p300 in interferon γ signaling

1996 • 486 citations

Involvement of PIAS1 in the Sumoylation of Tumor Suppressor p53

2001 • 447 citations

A DNA Damage Response Pathway Controlled by Tel1 and the Mre11 Complex

2001 • 384 citations

Opposing Effects of Ras on p53

2000 • 361 citations

High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons.

1991 • 269 citations

Stat1 combines signals derived from IFN-gamma and LPS receptors during macrophage activation

1998 • 240 citations

A Novel Cofactor for p300 that Regulates the p53 Response

1999 • 218 citations

Ischemia-induced STAT-1 Expression and Activation Play a Critical Role in Cardiomyocyte Apoptosis

2000 • 208 citations

Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-γ target genes

2000 • 200 citations

Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression

2001 • 195 citations

Induction of Apoptosis and Fas Receptor/Fas Ligand Expression by Ischemia/Reperfusion in Cardiac Myocytes Requires Serine 727 of the STAT-1 Transcription Factor but Not Tyrosine 701

2001 • 175 citations

STAT1 Affects Lymphocyte Survival and Proliferation Partially Independent of Its Role Downstream of IFN-γ

2000 • 144 citations

The loss of mdm2 induces p53 mediated apoptosis

2000 • 137 citations

Identification of BARD1 as Mediator between Proapoptotic Stress and p53-Dependent Apoptosis

2001 • 115 citations

Stat1-Dependent, p53-Independent Expression of p21^waf1 Modulates Oxysterol-Induced Apoptosis

2002 • 99 citations

STAT1 Is Inactivated by a Caspase

1998 • 94 citations

The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21CIP1/Waf1

2002 • 54 citations

The C‐terminal activation domain of the STAT‐1 transcription enhances ischemia/reperfusion‐induced apoptosis in cardiac myocytes

2002 • 54 citations

Interferon Review

1987 • 45 citations

The C-terminal activation domain of the STAT-1 transcription factor is necessary and sufficient for stress-induced apoptosis

2002 • 29 citations

Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter

2002 • 19 citations