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Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury

Data up to Jan 2025

Published2005
Citations338
References50

Total Citations Per Year

Abstract

References (50)

Methods in Enzymology , Vol

1966 • 26,261 citations

DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION

1949 • 16,078 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning

2003 • 2,040 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

Myocardial reperfusion: a double-edged sword?

1985 • 1,355 citations

Preconditioning the Myocardium: From Cellular Physiology to Clinical Cardiology

2003 • 1,051 citations

Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion

1995 • 830 citations

Opening of the Mitochondrial Permeability Transition Pore Causes Depletion of Mitochondrial and Cytosolic NAD+and Is a Causative Event in the Death of Myocytes in Postischemic Reperfusion of the Heart

2001 • 658 citations

Postconditioning: A Form of “Modified Reperfusion” Protects the Myocardium by Activating the Phosphatidylinositol 3-Kinase-Akt Pathway

2004 • 657 citations

Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?

2002 • 579 citations

Protection by Cyclosporin A of Ischemia/Reperfusion-Induced Damage in Isolated Rat Hearts

1993 • 571 citations

Myocardial reperfusion, limitation of infarct size, reduction of left ventricular dysfunction, and improved survival. Should the paradigm be expanded?

1989 • 560 citations

Myocardial Protection by Insulin at Reperfusion Requires Early Administration and Is Mediated via Akt and p70s6 Kinase Cell-Survival Signaling

2001 • 521 citations

Reperfusion injury and its pharmacologic modification.

1989 • 509 citations

Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways

2004 • 496 citations

Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia–reperfusion injury

2003 • 411 citations

Does reperfusion injury exist in humans?

1993 • 405 citations

Sanglifehrin A Acts as a Potent Inhibitor of the Mitochondrial Permeability Transition and Reperfusion Injury of the Heart by Binding to Cyclophilin-D at a Different Site from Cyclosporin A

2002 • 359 citations

Ischaemic Preconditioning Inhibits Opening of Mitochondrial Permeability Transition Pores in the Reperfused Rat Heart

2003 • 345 citations

Cellular mechanisms of ischemia-reperfusion injury

2003 • 339 citations

Factors involved in salvaging ischemic myocardium: effect of reperfusion of arterial blood.

1983 • 318 citations

Mitochondrial ATP-sensitive K+channels modulate cardiac mitochondrial function

1998 • 313 citations

On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury

1993 • 295 citations

Triphenyltetrazolium staining of irreversible ischemic injury following coronary artery occlusion in rats.

1985 • 286 citations

Inhibition of the Mitochondrial Permeability Transition by the Nonimmunosuppressive Cyclosporin Derivative NIM811

2002 • 280 citations

Transport of calcium by mitochondria

1994 • 276 citations

Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A

1991 • 261 citations

Atorvastatin, administered at the onset of reperfusion, and independent oflipid lowering, protects the myocardiumby up-regulating a pro-survival pathway

2003 • 257 citations

An essential role of NFκB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia

1998 • 232 citations

Ischemic Preconditioning Reduces Apoptosis By Upregulating Anti-Death Gene Bcl-2

1999 • 216 citations

STUDIES OF CONTROLLED REPERFUSION AFTER ISCHEMIA

1986 • 214 citations

Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury

2000 • 211 citations

Preconditioning delays Ca2+-induced mitochondrial permeability transition

2004 • 175 citations

Bradykinin limits infarction when administered as an adjunct to reperfusion in mouse heart: the role of PI3K, Akt and eNOS

2003 • 173 citations

Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: support for a mitochondrial role in cardioprotection

2000 • 163 citations

Effect of inhibition of Na+/Ca2+ exchanger at the time of myocardial reperfusion on hypercontracture and cell death

2002 • 156 citations

Characteristics of the Calcium‐Triggered Mitochondrial Permeability Transition in Nonsynaptic Brain Mitochondria

2000 • 120 citations

Cyclosporin A and its nonimmunosuppressive analogue N‐Me‐Val‐4‐cyclosporin A mitigate glucose/oxygen deprivation‐induced damage to rat cultured hippocampal neurons

1999 • 113 citations

Cardioprotective Effects of Transforming Growth Factor-β1 During Early Reoxygenation or Reperfusion Are Mediated by p42/p44 MAPK

2001 • 102 citations

PHARMACOLOGICAL PRECONDITIONING WITH LOW-DOSE CYCLOSPORINE OR FK506 REDUCES SUBSEQUENT ISCHEMIA/REPERFUSION INJURY IN RAT KIDNEY1,2

2001 • 101 citations

Cyclosporine A limits myocardial infarct size even when administered after onset of ischemia

1998 • 86 citations

Inhibition of Cell Cycle Progression by the Novel Cyclophilin Ligand Sanglifehrin A Is Mediated through the NFκB-dependent Activation of p53

2001 • 57 citations

Apoptosis-Related Activities Measured with Isolated Mitochondria and Digitonin-Permeabilized Cells

2000 • 55 citations

Role of nuclear factor‐κB activation in acute ischaemia‐reperfusion injury in myocardium

2003 • 53 citations

Preconditioning with cyclosporine a or fk506 differentially regulates mitogen-activated protein kinase expression in rat kidneys with ischemia/reperfusion injury12

2003 • 52 citations

Changes in Hsp90 expression determine the effects of cyclosporine A on the NO pathway in rat myocardium

2003 • 42 citations

Close Association Between the Reduction in Myocardial Energy Metabolism and Infarct Size: Dose-Response Assessment of Cyclosporine

2002 • 41 citations

Calcium-binding properties of the mitochondrial channel-forming hydrophobic component.

2000 • 23 citations

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Specific inhibition of the mitochondrial permeability transition prevents lethal… (2005) – Journal of Molecular and Cellular Cardiology | Metascience Observatory Explorer