Cyclophilin D, a Component of the Permeability Transition-Pore, Is an Apoptosis Repressor

The Hallmarks of Cancer

2000 • 27,569 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

Role of reactive oxygen species (ROS) in apoptosis induction.

2000 • 2,602 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 2,326 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

1995 • 1,761 citations

Mitochondrial control of apoptosis

1997 • 1,500 citations

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

2000 • 1,484 citations

Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

1990 • 1,390 citations

Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

1997 • 1,329 citations

Apoptosis control by death and decoy receptors

1999 • 1,296 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

The inhibitors of apoptosis (IAPs) and their emerging role in cancer

1998 • 985 citations

RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

1995 • 964 citations

Breaking the mitochondrial barrier

2001 • 947 citations

Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase

1990 • 738 citations

Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization

2002 • 727 citations

The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

1998 • 700 citations

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis

1999 • 680 citations

Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions

1998 • 645 citations

Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90

2000 • 558 citations

Mitochondrion as a Novel Target of Anticancer Chemotherapy

2000 • 536 citations

Cyclophilin‐D binds strongly to complexes of the voltage‐dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore

1998 • 475 citations

Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins

1998 • 421 citations

Caspase-2 Is Localized at the Golgi Complex and Cleaves Golgin-160 during Apoptosis

2000 • 379 citations

p28 Bap31, a Bcl-2/Bcl-XL- and Procaspase-8–associated Protein in the Endoplasmic Reticulum

1997 • 322 citations

Arsenite Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore

1999 • 307 citations

Active site mutants of human cyclophilin A separate peptidyl‐prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition

1992 • 287 citations

Arachidonic Acid Causes Cell Death through the Mitochondrial Permeability Transition

2001 • 284 citations

Adenine Nucleotide Translocase-1, a Component of the Permeability Transition Pore, Can Dominantly Induce Apoptosis

1999 • 278 citations

Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2.

1994 • 262 citations

PIN1 Is an E2F Target Gene Essential for Neu/Ras-Induced Transformation of Mammary Epithelial Cells

2002 • 249 citations

Protective Effect of the Energy Precursor Creatine Against Toxicity of Glutamate and β‐Amyloid in Rat Hippocampal Neurons

2000 • 221 citations

Measurements of ATP in mammalian cells

2002 • 221 citations

Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437

2001 • 190 citations

The mitochondrial permeability transition: its molecular mechanism and role in reperfusion injury

1999 • 189 citations

Mitochondrial Targeted Cyclophilin D Protects Cells from Cell Death by Peptidyl Prolyl Isomerization

2002 • 171 citations

Bcl-2 and Bax modulate adenine nucleotide translocase activity.

2003 • 168 citations

Involvement of Cyclophilin D in the Activation of A mitochondrial Pore by Ca²⁺ and Oxidant Stress

1996 • 163 citations

Functional Activation of Nedd2/ICH-1 (Caspase-2) Is an Early Process in Apoptosis

1997 • 142 citations

Collapse of the Inner Mitochondrial Transmembrane Potential Is Not Required for Apoptosis of HL60 Cells

1999 • 124 citations

Apoptosis and cardiomyopathy

2000 • 105 citations

The presence of two classes of high‐affinity cyclosporin A binding sites in mitochondria

1990 • 104 citations

Cyclosporine induces different responses in human epithelial, endothelial and fibroblast cell cultures

2000 • 98 citations

Sendai Virus Infection Induces Apoptosis through Activation of Caspase-8 (FLICE) and Caspase-3 (CPP32)

1999 • 94 citations

Role of Bcl‐2 family of proteins in malignancy

2001 • 87 citations

Apoptosis in breast cancer: relationship with other pathological parameters.

1999 • 80 citations

Spike, a novel BH3‐only protein, regulates apoptosis at the endoplasmic reticulum

2003 • 77 citations

Estradiol-Regulated Expression of the Immunophilins Cyclophilin 40 and FKBP52 in MCF-7 Breast Cancer Cells

2001 • 76 citations

Neuroprotective effects of creatine administration against NMDA and malonate toxicity

2000 • 75 citations

The Tumor Suppressor cybL, a Component of the Respiratory Chain, Mediates Apoptosis Induction

2003 • 75 citations

On the inhibition of the adenine nucleotide translocation by bongkrekic acid

1970 • 71 citations

Chaperone‐like activity of peptidyl‐prolyl cis‐trans isomerase during creatine kinase refolding

2001 • 61 citations

The Role of Molecular Chaperones in Mitochondrial Protein Import and Folding

1997 • 58 citations

Structure-function relationships of the ADP/ATP carrier

1994 • 52 citations

Transient protection by peripheral benzodiazepine receptors during the early events of ultraviolet light-induced apoptosis

2001 • 52 citations

Adenine nucleotide translocator in dilated cardiomyopathy: pathophysiological alterations in expression and function.

1997 • 48 citations

The metastasis suppressor gene C33/CD82/KAI1 induces apoptosis through reactive oxygen intermediates

2003 • 44 citations

An Apoptosis-inducing Isoform of Neu Differentiation Factor (NDF) Identified Using a Novel Screen for Dominant, Apoptosis-inducing Genes

1997 • 36 citations

Modulation of cyclophilin gene expression by N‐4‐(hydroxyphenyl)retinamide: Association with reactive oxygen species generation and apoptosis*

2002 • 26 citations

trans-Complementation Rescue of Cyclophilin A-Deficient Viruses Reveals that the Requirement for Cyclophilin A in Human Immunodeficiency Virus Type 1 Replication Is Independent of Its Isomerase Activity

2002 • 26 citations

Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines

1998 • 21 citations

Cyclosporin‐A Differentially Affects Apoptosis During In Vivo Rat Thymocyte Maturation

2002 • 12 citations

Adenine nucleotide translocator in dilated cardiomyopathy: Pathophysiological alterations in expression and function

1997 • 7 citations