Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

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Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

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The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

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A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis

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Bax interacts with the permeability transition pore to induce permeability transition and cytochromecrelease in isolated mitochondria

1998 • 932 citations

Bax-induced Caspase Activation and Apoptosis via Cytochromec Release from Mitochondria Is Inhibitable by Bcl-xL

1999 • 717 citations

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Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

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Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions

1998 • 645 citations

Role of the Mitochondrial Permeability Transition in Myocardial Disease

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Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux

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Exercise Provides Direct Biphasic Cardioprotection via Manganese Superoxide Dismutase Activation

1999 • 366 citations

Ischaemic Preconditioning Inhibits Opening of Mitochondrial Permeability Transition Pores in the Reperfused Rat Heart

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Peptidylproline cis/trans isomerases

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Blockade of the Mitochondrial Permeability Transition Pore Diminishes Infarct Size in the Rat after Transient Middle Cerebral Artery Occlusion

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Event timing turns punishment to reward

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Selective Loading of Rhod 2 into Mitochondria Shows Mitochondrial Ca2+Transients during the Contractile Cycle in Adult Rabbit Cardiac Myocytes

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Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis

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The Mitochondrial Permeability Transition Augments Fas-induced Apoptosis in Mouse Hepatocytes

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Contribution of increased mitochondrial free Ca2+ to the mitochondrial permeability transition induced bytert-butylhydroperoxide in rat hepatocytes

1999 • 122 citations

Cyclosporin A and its nonimmunosuppressive analogue N‐Me‐Val‐4‐cyclosporin A mitigate glucose/oxygen deprivation‐induced damage to rat cultured hippocampal neurons

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PLA2 activity is required for nuclear shrinkage in caspase-independent cell death

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