Electrophysiology of the inner mitochondrial membrane

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

Regulation of the Voltage Gated K<sup>+</sup> Channel K<sub>v1.3</sub> by Recombinant Human Klotho Protein

2014 • 5,592 citations

Single-Channel Recording

1995 • 2,565 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Single channel recording

1984 • 981 citations

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.

1988 • 846 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 826 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 751 citations

ATP-sensitive K+ channel in the mitochondrial inner membrane

1991 • 746 citations

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

1989 • 699 citations

Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier.

1992 • 692 citations

Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations.

1992 • 449 citations

The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism

1989 • 443 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.

1992 • 443 citations

Brown adipose tissue mitochondria

1979 • 369 citations

The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A

1991 • 368 citations

Reconstitution and partial purification of the glibenclamide-sensitive, ATP-dependent K+ channel from rat liver and beef heart mitochondria.

1992 • 358 citations

The inhibition of mitochondrial calcium transport by lanthanides and Ruthenium Red

1974 • 351 citations

Voltage gating in the mitochondrial channel, VDAC

1989 • 296 citations

Kinetic evidence for a heart mitochondrial pore activated by Ca²⁺, inorganic phosphate and oxidative stress

1988 • 293 citations

Membrane protein oligomeric structure and transport function

1981 • 277 citations

Mechanism and evolution of the uncoupling protein of brown adipose tissue

1990 • 270 citations

The mitochondrial megachannel is the permeability transition pore

1992 • 262 citations

Modulation of the mitochondrial megachannel by divalent cations and protons.

1992 • 232 citations

Patch-clamping of the inner mitochondrial membrane reveals a voltage-dependent ion channel

1987 • 232 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. II. The minimal requirements for pore induction underscore a key role for transmembrane electrical potential, matrix pH, and matrix Ca2+.

1993 • 225 citations

The inner mitochondrial membrane contains ion‐conducting channels similar to those found in bacteria

1989 • 224 citations

Mitochondrial channel activity studied by patch-clamping mitoplasts

1989 • 206 citations

The structure of mitochondria

1976 • 200 citations

NADH regulates the gating of VDAC, the mitochondrial outer membrane channel.

1994 • 200 citations

Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands.

1993 • 198 citations

Contact sites between mitochondrial envelope membranes. Structure and function in energy- and protein-transfer

1991 • 187 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by matrix pH. Evidence that the pore open-closed probability is regulated by reversible histidine protonation

1993 • 181 citations

The mitochondrial permeability transition pore may comprise VDAC molecules

1993 • 172 citations

The mitochondrial permeability transition pore may comprise VDAC molecules

1993 • 166 citations

Integration of Mitochondrial Function

1988 • 165 citations

The peripheral‐type benzodiazepine receptor: a protein of mitochondrial outer membranes utilizing porphyrins as endogenous ligands

1987 • 159 citations

Allosteric inhibition of the Ca2+-activated hydrophilic channel of the mitochondrial inner membrane by nucleotides

1980 • 157 citations

Calcium-dependent opening of a non-specific pore in the mitochondrial inner membrane is inhibited at pH values below 7. Implications for the protective effect of low pH against chemical and hypoxic cell damage

1991 • 149 citations

Toward the molecular structure of the mitochondrial channel, VDAC

1992 • 149 citations

Kinetics of calcium(2+) ion carrier in rat liver mitochondria

1979 • 143 citations

Properties of the inner membrane anion channel in intact mitochondria

1992 • 139 citations

Evidence for the existence of an inner membrane anion channel in mitochondria

1986 • 126 citations

The mitochondrial aspartate/glutamate and ADP/ATP carrier switch from obligate counterexchange to unidirectional transport after modification by SH-reagents

1990 • 126 citations

Channels in Mitochondrial Membranes: Knowns, Unknowns, and Prospects for the Future

1993 • 123 citations

The Structure of Mitochondria

1975 • 112 citations

The equivalent pore radius of intact and damaged mitochondria and the mechanism of active shrinkage

1972 • 106 citations

The presence of two classes of high‐affinity cyclosporin A binding sites in mitochondria

1990 • 104 citations

New substrates and competitive inhibitors of the Cl- translocating pathway of the uncoupling protein of brown adipose tissue mitochondria.

1990 • 104 citations

On the regulation of K+ uniport in intact mitochondria by adenine nucleotides and nucleotide analogs.

1993 • 104 citations

The ‘ins’ and ‘outs’ of mitochondrial membrane channels

1992 • 101 citations

Pore-like and carrier-like properties of the mitochondrial aspartate/glutamate carrier after modification by SH-reagents: evidence for a preformed channel as a structural requirement of carrier-mediated transport

1990 • 100 citations

Regulation of the mitochondrial matrix volume in vivo and in vitro. The role of calcium

1986 • 97 citations

Modulation of inner mitochondrial membrane channel activity

1992 • 97 citations

Dialectics in carrier research: The ADP/ATP carrier and the uncoupling protein

1993 • 95 citations

The effect of antimycin A on mouse liver inner mitochondrial membrane channel activity.

1992 • 95 citations

Partial inhibition by cyclosporin A of the swelling of liver mitochondria in vivo and in vitro induced by sub-micromolar [Ca2+], but not by butyrate. Evidence for two distinct swelling mechanisms

1990 • 88 citations

Calcium modulation of mitochondrial inner membrane channel activity

1991 • 87 citations

Triorganotins inhibit the mitochondrial inner membrane anion channel.

1991 • 86 citations

Voltage activation of heart inner mitochondrial membrane channels

1992 • 81 citations

Electrophysiological characterization of contact sites in brain mitochondria.

1990 • 79 citations

The mitochondrial benzodiazepine receptor: Evidence for association with the voltage-dependent anion channel (VDAC)

1992 • 76 citations

On the Inhibition of the Mitochondrial Inner Membrane Anion Uniporter by Cationic Amphiphiles and Other Drugs

1989 • 75 citations

Mg2+ and the permeability of heart mitochondria to monovalent cations

1976 • 74 citations

Hamster Brown‐Adipose‐Tissue Mitochondria

1974 • 74 citations

The mitochondrial inner membrane anion channel. Regulation by divalent cations and protons.

1987 • 74 citations

Characterization of porphyrin interactions with peripheral type benzodiazepine receptors.

1988 • 72 citations

Selectivity for Omega-Receptor Subtypes as a Strategy for the Development of Anxiolytic Drugs

1990 • 71 citations

Incorporation in lipid bilayers of a large conductance cationic channel from mitochondrial membranes.

1988 • 63 citations

Crucial role of sulfhydryl groups in the mitochondrial inner membrane structure.

1985 • 62 citations

Reconstitution of the uncoupling protein of brown adipose tissue mitochondria. Demonstration of GDP-sensitive halide anion uniport.

1990 • 62 citations

Osmotic swelling of heart mitochondria in acetate and chloride salts

1978 • 62 citations

Blockade of a mitochondrial cationic channel by an addressing peptide: An electrophysiological study

1989 • 58 citations

Patch clamping VDAC in liposomes containing whole mitochondrial membranes

1991 • 58 citations

Cross-linking analysis of yeast mitochondrial outer membrane

1986 • 57 citations

On the Regulation of the Mitochondrial Inner Membrane Anion Channel by Magnesium and Protons

1989 • 55 citations

Further investigation on the high-conductance ion channel of the inner membrane of mitochondria

1989 • 53 citations

Comparison of mitochondrial cationic channels in wild-type and porin-deficient mutant yeast

1990 • 49 citations

Ion permeability induced in artificial membranes by the ATP/ADP antiporter

1994 • 49 citations

Inner mitochondrial membrane anion channel is present in brown adipocytes but is not identical with the uncoupling protein

1991 • 46 citations

Properties of the mitochondrial peptide-sensitive cationic channel studied in planar bilayers and patches of giant liposomes

1992 • 44 citations

A peptide‐sensitive channel of large conductance is localized on mitochondrial outer membrane

1991 • 44 citations

Multiple conductance levels in rat heart inner mitochondrial membranes studied by patch clamping

1992 • 44 citations

Activation of Latent K+ Uniport in Mitochondria Treated with the Ionophore A23187

1989 • 42 citations

Single anion channels reconstituted from cardiac mitoplasts

1993 • 41 citations

Selective effect of inhibitors on inner mitochondrial membrane channels

1991 • 40 citations

An Anion-Conducting Pore in the Mitochondrial Inner Membrane

1979 • 39 citations

Molecular Biology of Mitochondrial Transport Systems

1994 • 37 citations

The K+ conductance of the inner mitochondrial membrane. A study of the inducible uniport for monovalent cations

1991 • 37 citations

Isolation and properties of Ca2+-transporting glycoprotein and peptide from beef heart mitochondria

1982 • 35 citations

Purification of the channel component of the mitochondrial calcium uniporter and its reconstitution into planar lipid bilayers

1994 • 35 citations

Basic peptides can be imported into yeast mitochondria by two distinct targeting pathways. Involvement of the peptide-sensitive channel of the outer membrane.

1994 • 33 citations

Reconstitution of the native mitochondrial outer membrane in planar bilayers. Comparison with the outer membrane in a patch pipette and effect of aluminum compounds

1993 • 33 citations

Evidence for three different electrophoretic pathways in yeast mitochondria: Ion specificity and inhibitor sensitivity

1993 • 33 citations

Inhibition of the mitochondrial inner membrane anion channel by dicyclohexylcarbodiimide. Evidence for a specific transport pathway.

1988 • 32 citations

Identification of anion and cation pathways in the inner mitochondrial membrane by patch clamping of mouse liver mitoplasts

1991 • 32 citations

Inhibition of the mitochondrial calcium uniporter by antibodies against a 40-kDa glycorproteinT

1993 • 31 citations

Reversible and irreversible effects of basic peptides on the mitochondrial cationic channel

1994 • 28 citations

Ruthenium red inhibits mitochondrial Na+ and K+ uniports induced by magnesium removal.

1990 • 25 citations

Purification and patch clamp analysis of a 40-pS channel from rat liver mitochondria

1992 • 24 citations

High-conductance pathways in mitochondrial membranes

1992 • 23 citations

A gated pathway for electrophoretic Na⁺ fluxes in rat liver mitochondria

1990 • 23 citations

Permeability of the mitochondrial membrane to bicarbonate ions

1977 • 18 citations

Structural features of a multisubstate cardiac mitoplast anion channel: Inferences from single channel recording

1993 • 18 citations

A mitochondrial protein fraction catalyzing transport of the K⁺ analog Tl⁺

1990 • 17 citations

Patch clamp analysis of a partially purified ion channel from rat liver mitochondria

1991 • 17 citations

Structure of Mitochondria

1976 • 14 citations

Solubilization and reconstitution of the mitochondrial peptide-sensitive channel

1993 • 13 citations

Calcium ion activation of the anion‐conducting channel in the rat liver mitochondrial inner membrane

1990 • 7 citations

Voltage-Dependent Channels are Present in the Inner Membrane of Mitochondria

1988 • 3 citations

[Peripheral benzodiazepine receptors and their possible biological role].

1993 • 2 citations

Deleted Work

1955 • 0 citations