ASC is a Bax adaptor and regulates the p53–Bax mitochondrial apoptosis pathway

Mitochondria and Apoptosis

1998 • 8,909 citations

Surfing the p53 network

2000 • 6,487 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

A simplified system for generating recombinant adenoviruses

1998 • 3,179 citations

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1995 • 1,552 citations

The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues

2000 • 1,427 citations

Structure of Bax

2000 • 1,066 citations

Decision making by p53: life, death and cancer

2003 • 1,055 citations

Role ofBAXin the Apoptotic Response to Anticancer Agents

2000 • 854 citations

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

2001 • 815 citations

Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization

2002 • 727 citations

Conformation of the Bax C-terminus regulates subcellular location and cell death

1999 • 723 citations

Humanin peptide suppresses apoptosis by interfering with Bax activation

2003 • 578 citations

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

2002 • 564 citations

ASC, a Novel 22-kDa Protein, Aggregates during Apoptosis of Human Promyelocytic Leukemia HL-60 Cells

1999 • 516 citations

Bax in Murine Thymus Is a Soluble Monomeric Protein That Displays Differential Detergent-induced Conformations

1998 • 508 citations

Targeted Disruption of Pyrin, the FMF Protein, Causes Heightened Sensitivity to Endotoxin and a Defect in Macrophage Apoptosis

2003 • 409 citations

Ku70 suppresses the apoptotic translocation of Bax to mitochondria

2003 • 358 citations

TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers.

2000 • 251 citations

The role of the Bcl-2 protein family in cancer

2003 • 245 citations

ASC is an activating adaptor for NF-κB and caspase-8-dependent apoptosis

2003 • 207 citations

Deciphering the pathways of life and death

1999 • 175 citations

Oncogene-dependent apoptosis is mediated by caspase-9

1998 • 174 citations

The PAAD/PYRIN-Family Protein ASC Is a Dual Regulator of a Conserved Step in Nuclear Factor κB Activation Pathways

2002 • 165 citations

PAAD – a new protein domain associated with apoptosis, cancer and autoimmune diseases

2001 • 139 citations

Pyrin N-Terminal Homology Domain- and Caspase Recruitment Domain-Dependent Oligomerization of ASC

2001 • 89 citations

ASC, which is composed of a PYD and a CARD, is up-regulated by inflammation and apoptosis in human neutrophils

2002 • 87 citations

Activation of a caspase-9-mediated apoptotic pathway by subcellular redistribution of the novel caspase recruitment domain protein TMS1.

2000 • 85 citations

Methylation-mediated Silencing of TMS1/ASC Is Accompanied by Histone Hypoacetylation and CpG Island-localized Changes in Chromatin Architecture

2002 • 53 citations