Do inducers of apoptosis trigger caspase-independent cell death?

Cell Death

2004 • 4,599 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

2000 • 1,807 citations

Endonuclease G is an apoptotic DNase when released from mitochondria

2001 • 1,725 citations

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

1998 • 1,642 citations

Corpse clearance defines the meaning of cell death

2000 • 1,528 citations

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

2001 • 1,327 citations

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

1998 • 1,292 citations

Regulation of an ATG7 - beclin 1 Program of Autophagic Cell Death by Caspase-8

2004 • 1,204 citations

A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death

2001 • 1,106 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian Development

1998 • 894 citations

Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor

1998 • 887 citations

Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition

1999 • 663 citations

AIF deficiency compromises oxidative phosphorylation

2004 • 600 citations

The harlequin mouse mutation downregulates apoptosis-inducing factor

2002 • 595 citations

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

2002 • 564 citations

Do all programmed cell deaths occur via apoptosis?

1993 • 545 citations

Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization

2003 • 434 citations

Phosphatidylserine Receptor Is Required for Clearance of Apoptotic Cells

2003 • 396 citations

Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice

2004 • 383 citations

Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice

2003 • 370 citations

Caspase-independent Cell Killing by Fas-associated Protein with Death Domain

1998 • 317 citations

Interdigital cell death can occur through a necrotic and caspase-independent pathway

1999 • 316 citations

Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities.

1996 • 236 citations

Primers for Mitochondrial DNA Replication Generated by Endonuclease G

1993 • 230 citations

Caspase inhibition causes hyperacute tumor necrosis factor–induced shock via oxidative stress and phospholipase A2

2003 • 212 citations

The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal.

2004 • 208 citations

Cell Corpse Engulfment Mediated by C. elegans Phosphatidylserine Receptor Through CED-5 and CED-12

2003 • 195 citations

Caspase Inhibition Extends the Commitment to Neuronal Death Beyond Cytochrome c Release to the Point of Mitochondrial Depolarization

2000 • 183 citations

Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death

1998 • 179 citations

Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AIF release

2004 • 121 citations

Purification and characterization of active human interleukin-1 beta-converting enzyme from THP.1 monocytic cells.

1993 • 111 citations

Endonuclease G is required for early embryogenesis and normal apoptosis in mice

2003 • 95 citations

Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and Endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis

1995 • 93 citations

Mutational Analysis of the Caenorhabditis elegans Cell-Death Gene ced-3

1999 • 91 citations

Apaf-1 deficiency and neural tube closure defects are found in fog mice

2001 • 83 citations

Ligation of Major Histocompatability Complex (MHC) Class I Molecules on Human T Cells Induces Cell Death through PI-3 Kinase–induced c-Jun NH2-terminal Kinase Activity: A Novel Apoptotic Pathway Distinct from Fas-induced Apoptosis

1997 • 77 citations