Trimetazidine inhibits mitochondrial permeability transition pore opening and prevents lethal ischemia–reperfusion injury

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The Antianginal Drug Trimetazidine Shifts Cardiac Energy Metabolism From Fatty Acid Oxidation to Glucose Oxidation by Inhibiting Mitochondrial Long-Chain 3-Ketoacyl Coenzyme A Thiolase

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1997 • 422 citations

Ischaemic Preconditioning Inhibits Opening of Mitochondrial Permeability Transition Pores in the Reperfused Rat Heart

2003 • 345 citations

Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury

2005 • 338 citations

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1998 • 313 citations

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1985 • 286 citations

Trimetazidine: a new concept in the treatment of angina. Comparison with propranolol in patients with stable angina. Trimetazidine European Multicenter Study Group.

1994 • 240 citations

The cardiolipin–cytochrome c interaction and the mitochondrial regulation of apoptosis

2004 • 228 citations

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1990 • 179 citations

Preconditioning delays Ca2+-induced mitochondrial permeability transition

2004 • 175 citations

Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: support for a mitochondrial role in cardioprotection

2000 • 163 citations

Stretch preconditions canine myocardium

1994 • 131 citations

Characteristics of the Calcium‐Triggered Mitochondrial Permeability Transition in Nonsynaptic Brain Mitochondria

2000 • 120 citations

Trimetazidine counteracts the hepatic injury associated with ischemia-reperfusion by preserving mitochondrial function.

1998 • 76 citations

Ceramide in the antiapoptotic effect of ischemic preconditioning

2004 • 69 citations

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Evidence for the existence of [³H]‐trimetazidine binding sites involved in the regulation of the mitochondrial permeability transition pore

1998 • 53 citations

Protective effect of trimetazidine on myocardial mitochondrial function in an ex-vivo model of global myocardial ischemia

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Limitation of Infarct Size by Trimetazidine in the Rabbit

1995 • 44 citations

Infarct size in rabbits: a modified method illustrated by the effects of propranolol and trimetazidine

1993 • 29 citations

Influence of Trimetazidine on the synthesis of complex lipids in the heart and other target organs

2001 • 24 citations

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Effects of trimetazidine on myocardial preconditioning in anesthetized rats

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Mitochondrial Permeability Transition in Cardiomyocyte Apoptosis during Acute Graft Rejection

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Does Trimetazidine Exert Cytoprotective Activity on Astrocytes Subjected to Hypoxia In Vitro?

2001 • 13 citations

Inhibitory effect of trimetazidine on cardiac myocyte apoptosis in rabbit model of ischemia-reperfusion.

2004 • 12 citations