Calcium signaling and apoptosis

The versatility and universality of calcium signalling

2000 • 5,407 citations

The expanding role of mitochondria in apoptosis.

2001 • 2,377 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 2,326 citations

Mitochondria as the central control point of apoptosis

2000 • 1,875 citations

Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition

1999 • 1,509 citations

Reactive Oxygen Species (Ros-Induced) Ros Release

2000 • 1,324 citations

Mitochondria and Neuronal Survival

2000 • 1,206 citations

Cross-Talk between Two Cysteine Protease Families

2000 • 1,158 citations

The mitochondrion in apoptosis: how Pandora's box opens

2001 • 1,035 citations

A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis

2002 • 1,015 citations

Mitochondrial permeability transition and oxidative stress

2001 • 842 citations

Mitochondrial ATP-Dependent Potassium Channels

1998 • 825 citations

Calcium and oxidative stress: from cell signaling to cell death

2002 • 803 citations

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

2002 • 801 citations

The permeability transition pore complex: another view

2002 • 702 citations

The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

2001 • 578 citations

VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release

2001 • 507 citations

Apoptosis driven by IP3-linked mitochondrial calcium signals

1999 • 492 citations

Cytoprotective Role of Ca ²⁺ - Activated K ⁺ Channels in the Cardiac Inner Mitochondrial Membrane

2002 • 478 citations

Reduced Loading of Intracellular Ca2+ Stores and Downregulation of Capacitative Ca2+Influx in Bcl-2–Overexpressing Cells

2000 • 462 citations

Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function?

2002 • 433 citations

Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria

2002 • 432 citations

A mitochondrial perspective on cell death

2001 • 430 citations

Bcl-2 decreases the free Ca ²⁺ concentration within the endoplasmic reticulum

2000 • 417 citations

Ion homeostasis and apoptosis

2001 • 379 citations

Role of Mitochondrial Inner Membrane Permeabilization in Necrotic Cell Death, Apoptosis, and Autophagy

2002 • 366 citations

Bcl-x Promotes the Open Configuration of the Voltage-dependent Anion Channel and Metabolite Passage through the Outer Mitochondrial Membrane

2001 • 356 citations

Bioenergetic consequences of opening the ATP-sensitive K⁺channel of heart mitochondria

2001 • 355 citations

ATP‐sensitive K⁺ channel openers prevent Ca²⁺ overload in rat cardiac mitochondria

1999 • 353 citations

Calcium binding and translocation by the voltage-dependent anion channel: a possible regulatory mechanism in mitochondrial function

2001 • 350 citations

Characterization of the signal that directs Bcl-xL, but not Bcl-2, to the mitochondrial outer membrane

2003 • 343 citations

Mitochondrial Nitric-oxide Synthase Stimulation Causes Cytochrome c Release from Isolated Mitochondria

1999 • 333 citations

Bax and Bak Promote Apoptosis by Modulating Endoplasmic Reticular and Mitochondrial Ca2+ Stores

2002 • 321 citations

Bcl-x_L Prevents the Initial Decrease in Mitochondrial Membrane Potential and Subsequent Reactive Oxygen Species Production during Tumor Necrosis Factor Alpha-Induced Apoptosis

2000 • 313 citations

Losing heart: the role of apoptosis in heart disease—a novel therapeutic target?

2002 • 296 citations

Ca2+-Activated K Channel of the BK-Type in the Inner Mitochondrial Membrane of a Human Glioma Cell Line

1999 • 296 citations

Arachidonic Acid Causes Cell Death through the Mitochondrial Permeability Transition

2001 • 284 citations

Identification and Properties of a Novel Intracellular (Mitochondrial) ATP-sensitive Potassium Channel in Brain

2001 • 282 citations

Recent insights into the mechanism of glucocorticosteroid-induced apoptosis

2002 • 282 citations

Necrotic Cell Death in C. elegans Requires the Function of Calreticulin and Regulators of Ca2+ Release from the Endoplasmic Reticulum

2001 • 277 citations

Calpain and Mitochondria in Ischemia/Reperfusion Injury

2002 • 276 citations

Mitochondrial oxidative stress and cell death in astrocytes —requirement for stored Ca2+ and sustained opening of the permeability transition pore

2002 • 265 citations

The voltage-dependent anion channel: an essential player in apoptosis

2002 • 250 citations

Preservation of Mitochondrial Structure and Function after Bid- or Bax-Mediated Cytochrome c Release

2000 • 244 citations

Mitochondria: a target for myocardial protection

2001 • 244 citations

Calpain-Mediated Bid Cleavage and Calpain-Independent Bak Modulation: Two Separate Pathways in Cisplatin-Induced Apoptosis

2002 • 239 citations

Calcium binding and translocation by the voltage-dependent anion channel: a possible regulatory mechanism in mitochondrial function

2001 • 232 citations

Propagation of the apoptotic signal by mitochondrial waves

2001 • 231 citations

Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator

2000 • 228 citations

Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax

2002 • 225 citations

Reactive oxygen species generated from the mitochondrial electron transport chain induce cytochrome c dissociation from beef‐heart submitochondrial particles via cardiolipin peroxidation. Possible role in the apoptosis

2001 • 217 citations

Bcl-2-dependent modulation of Ca2+ homeostasis and store-operated channels in prostate cancer cells

2002 • 213 citations

Ionomycin-activated Calpain Triggers Apoptosis

2002 • 207 citations

Cytochrome c Release Occurs via Ca2+-dependent and Ca2+-independent Mechanisms That Are Regulated by Bax

2001 • 206 citations

Bax-mediated Ca2+ Mobilization Promotes Cytochrome c Release during Apoptosis

2002 • 199 citations

Rapid Kinetics of tBid-induced Cytochrome c and Smac/DIABLO Release and Mitochondrial Depolarization

2002 • 180 citations

Calreticulin Differentially Modulates Calcium Uptake and Release in the Endoplasmic Reticulum and Mitochondria

2002 • 178 citations

Early changes in intramitochondrial cardiolipin distribution during apoptosis.

2002 • 177 citations

Bid acts on the permeability transition pore complex to induce apoptosis

2000 • 174 citations

Ca²⁺-Induced Increased Lipid Packing and Domain Formation in Submitochondrial Particles. A Possible Early Step in the Mechanism of Ca²⁺-Stimulated Generation of Reactive Oxygen Species by the Respiratory Chain

1999 • 163 citations

Mitochondria in Ca2+ signaling and apoptosis.

2000 • 160 citations

Bcl-2 prevents mitochondrial permeability transition and cytochrome c release via maintenance of reduced pyridine nucleotides

2000 • 159 citations

Menadione-induced apoptosis: roles of cytosolic Ca2+elevations and the mitochondrial permeability transition pore

2002 • 159 citations

Cabin1 Represses MEF2-Dependent Nur77 Expression and T Cell Apoptosis by Controlling Association of Histone Deacetylases and Acetylases with MEF2

2000 • 156 citations

A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c

2001 • 156 citations

Control of apoptosis by IP3and ryanodine receptor driven calcium signals

2000 • 151 citations

Effect of Bcl-2 Overexpression on Mitochondrial Structure and Function

2002 • 142 citations

Mitochondrial ATP‐Dependent Potassium Channels: Viable Candidate Effectors of Ischemic Preconditioning^a

1999 • 141 citations

The pro-apoptotic Bcl-2 family member tBid localizes to mitochondrial contact sites.

2001 • 141 citations

Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death

2002 • 128 citations

Electrical coupling and plasticity of the mitochondrial network

2000 • 118 citations

The adenine nucleotide translocator in apoptosis

2002 • 112 citations

Intracellular distribution of the fluorescent dye nonyl acridine orange responds to the mitochondrial membrane potential: implications for assays of cardiolipin and mitochondrial mass

2002 • 111 citations

Perturbed endoplasmic reticulum function, synaptic apoptosis and the pathogenesis of Alzheimer's disease

2001 • 105 citations

Mitochondrial Creatine Kinase and Mitochondrial Outer Membrane Porin Show a Direct Interaction That Is Modulated by Calcium

2001 • 100 citations

Depletion of Intracellular Ca2+ by Caffeine and Ryanodine Induces Apoptosis of Chinese Hamster Ovary Cells Transfected with Ryanodine Receptor

2000 • 100 citations

Bcl-X_Laffects Ca²⁺homeostasis by altering expression of inositol 1,4,5-trisphosphate receptors

2002 • 100 citations

Mitochondrial Ca2+homeostasis in the regulation of apoptotic and necrotic cell deaths

2000 • 92 citations

Epstein–Barr virus EBNA2 blocks Nur77- mediated apoptosis

2002 • 88 citations

Implication of mitochondria-derived ROS and cardiolipin peroxidation in N-(4-hydroxyphenyl)retinamide-induced apoptosis

2002 • 88 citations

tcBid promotes Ca2+ signal propagation to the mitochondria: control of Ca2+ permeation through the outer mitochondrial membrane

2002 • 81 citations

Synergistic Movements of Ca2+ and Bax in Cells Undergoing Apoptosis

2001 • 80 citations

Overexpression of Bcl‐2 suppresses the calcium activation of a mitochondrial megachannel

2001 • 53 citations

Mitochondrial Apoptosis and the Peripheral Benzodiazepine Receptor

2002 • 50 citations

A role for calcium in Bcl-2 action?

2002 • 47 citations

Membrane perturbations induced by the apoptotic Bax protein

2002 • 43 citations

Bcl-2 overexpression results in enhanced capacitative calcium entry and resistance to SKF-96365-induced apoptosis.

2000 • 38 citations

Mitochondrial Ca<sup>2+</sup> Signaling and Cardiac Apoptosis

2001 • 35 citations

Redox Control of Mitochondrial Functions

2001 • 33 citations

A Novel Function of BCL-2 Overexpression in Regulatory Volume Decrease

2002 • 30 citations

‘What nourishes me, destroys me’: towards a new mitochondrial biology

2001 • 18 citations

Spatio-Temporal Organization of the Mitochondrial Phase of Apoptosis

2001 • 12 citations

Bax gene expression alters Ca2+ signal transduction without affecting apoptosis in an epithelial cell line

2002 • 6 citations