Neisserial PorB is translocated to the mitochondria of HeLa cells infected with Neisseria meningitidis and protects cells from apoptosis

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1997 • 4,728 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

A New Method for the Cytofluorometric Analysis of Mitochondrial Membrane Potential Using the J-Aggregate Forming Lipophilic Cation 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine Iodide (JC-1)

1993 • 1,015 citations

Bax-induced Caspase Activation and Apoptosis via Cytochromec Release from Mitochondria Is Inhibitable by Bcl-xL

1999 • 717 citations

The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

1998 • 700 citations

Salmonella typhimurium invasion induces apoptosis in infected macrophages.

1996 • 601 citations

Inhibition of Apoptosis in Chlamydia-infected Cells: Blockade of Mitochondrial Cytochrome c Release and Caspase Activation

1998 • 586 citations

Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guérin.

1994 • 512 citations

A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2

1999 • 422 citations

Yersiniasignals macrophages to undergo apoptosis and YopJ is necessary for this cell death

1997 • 409 citations

The Induction of Apoptosis by Bacterial Pathogens

1999 • 409 citations

Pathogenic Mycobacterium tuberculosis evades apoptosis of host macrophages by release of TNF-R2, resulting in inactivation of TNF-alpha.

1998 • 375 citations

Bcl-x Promotes the Open Configuration of the Voltage-dependent Anion Channel and Metabolite Passage through the Outer Mitochondrial Membrane

2001 • 356 citations

Viruses and apoptosis

1995 • 324 citations

VDAC regulation by the Bcl-2 family of proteins

2000 • 323 citations

Interactions of Pathogenic Neisseriae with Epithelial Cell Membranes

2000 • 310 citations

Pathogenic Mycobacterium tuberculosis Evades Apoptosis of Host Macrophages by Release of TNF-R2, Resulting in Inactivation of TNF-α

1998 • 301 citations

VDAC, a Channel in the Outer Mitochondrial Membrane

1996 • 252 citations

The modulation of host cell apoptosis by intracellular bacterial pathogens

2000 • 237 citations

NF-κB-dependent inhibition of apoptosis is essential for host cell survival during Rickettsia rickettsii infection

1998 • 230 citations

In VitroBrucella suisInfection Prevents the Programmed Cell Death of Human Monocytic Cells

2000 • 217 citations

Listeria monocytogenes induces apoptosis of infected hepatocytes.

1996 • 213 citations

Type IV pili of pathogenic Neisseriae elicit cortical plaque formation in epithelial cells

1999 • 203 citations

The Serine/Threonine Kinase PAK4 Prevents Caspase Activation and Protects Cells from Apoptosis

2001 • 200 citations

Neisserial porin (PorB) causes rapid calcium influx in target cells and induces apoptosis by the activation of cysteine proteases

1999 • 192 citations

Apoptosis as a proinflammatory event: What can we learn from bacteria-induced cell death?

1997 • 187 citations

Opc‐ and pilus‐dependent interactions of meningococci with human endothelial cells: molecular mechanisms and modulation by surface polysaccharides

1995 • 182 citations

Differential induction of apoptosis by virulent Mycobacterium tuberculosis in resistant and susceptible murine macrophages: role of nitric oxide and mycobacterial products.

1997 • 182 citations

Neisseria meningitidisporin PorB interacts with mitochondria and protects cells from apoptosis

2000 • 170 citations

Mechanisms of Mucosal Invasion by Pathogenic Neisseria

1983 • 153 citations

Growth Phase-Regulated Induction of Salmonella -Induced Macrophage Apoptosis Correlates with Transient Expression of SPI-1 Genes

1999 • 153 citations

Neisseria gonorrhoeae Epithelial Cell Interaction Leads to the Activation of the Transcription Factors Nuclear Factor κB and Activator Protein 1 and the Induction of Inflammatory Cytokines

1997 • 151 citations

Interaction of Neisseria meningitidis with a polarized monolayer of epithelial cells

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Model for invasion of human tissue culture cells by Neisseria gonorrhoeae

1988 • 135 citations

Targeting of the pro-apoptotic VDAC-like porin (PorB) of Neisseria gonorrhoeae to mitochondria of infected cells

2000 • 133 citations

Modulation of Neisseria Porin (PorB) by Cytosolic ATP/GTP of Target Cells: Parallels between Pathogen Accommodation and Mitochondrial Endosymbiosis

1996 • 133 citations

M11l

2000 • 131 citations

Epithelial Cells Infected withChlamydophila pneumoniae(Chlamydia pneumoniae) Are Resistant to Apoptosis

2001 • 124 citations

Characterization of Antiapoptotic Activities ofChlamydia pneumoniaein Human Cells

2001 • 118 citations

Role of Oxidative Phosphorylation in Bax Toxicity

2000 • 118 citations

Neisserial porins induce B lymphocytes to express costimulatory B7-2 molecules and to proliferate.

1996 • 112 citations

Interactions of pathogenic Neisseria with host cells. Is it possible to assemble the puzzle?

1999 • 109 citations

Studies of Porins

1984 • 107 citations

Traversal of a Polarized Epithelium by Pathogenic Neisseriae: Facilitation by Type IV Pili and Maintenance of Epithelial Barrier Function

1996 • 107 citations

Cloning and Characterization of Mouse UBPy, a Deubiquitinating Enzyme That Interacts with the Ras Guanine Nucleotide Exchange Factor CDC25Mm/Ras-GRF1

2001 • 99 citations

Gonococcal Invasion of Epithelial Cells Driven by P.IA, a Bacterial Ion Channel with GTP Binding Properties

1998 • 94 citations

Inhibition of apoptosis in human immunodeficiency virus-infected cells enhances virus production and facilitates persistent infection

1995 • 93 citations

Mycobacterium bovis Bacillus Calmette Guérin infection prevents apoptosis of resting human monocytes

1997 • 87 citations

Analysis of epithelial cell stress response during infection by Shigella flexneri

1996 • 77 citations

Chlamydia pneumoniae Inhibits Apoptosis in Human Epithelial and Monocyte Cell Lines^*

2002 • 72 citations

Sequence of the structural gene (rmpM) for the class 4 outer membrane protein of Neisseria meningitidis, homology of the protein to gonococcal protein III and Escherichia coli OmpA, and construction of meningococcal strains that lack class 4 protein

1989 • 71 citations

[43] Characterization of channels isolated from plant mitochondria

1987 • 58 citations

Macropinocytosis as a Mechanism of Entry into Primary Human Urethral Epithelial Cells by Neisseria gonorrhoeae

2000 • 49 citations

Effect of sialylation of lipopolysaccharide of Neisseria gonorrhoeae on recognition and complement-mediated killing by monoclonal antibodies directed against different outer-membrane antigens

1995 • 41 citations

Characterization of the Structure, Function, and Conformational Stability of PorB Class 3 Protein from Neisseria meningitidis

1998 • 40 citations

Apoptosis as a common bacterial virulence strategy

2000 • 40 citations

: Clinical aspects

1997 • 33 citations

Interaction of the Gonococcal Porin P.IB with G- and F-Actin

2000 • 33 citations

Bacterial entry and intracellular processing of Neisseria gonorrhoeae in epithelial cells: immunomorphological evidence for alterations in the major outer membrane protein P.IB.

1991 • 32 citations

Protein III: structure, function, and genetics

1989 • 31 citations

Colony morphology of piliated Neisseria meningitidis.

1989 • 28 citations

Epithelial Barrier Function

2004 • 8 citations