The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal

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1978 • 12,818 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Mitochondrial control of cell death

2000 • 3,098 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 2,326 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide

1992 • 1,319 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

Isolation of Monoclonal Antibodies Specific for Human c-myc Proto-Oncogene Product

1985 • 788 citations

Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis

2000 • 778 citations

Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis

1997 • 727 citations

The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

1998 • 700 citations

Modulation of the Mitochondrial Permeability Transition Pore by Pyridine Nucleotides and Dithiol Oxidation at Two Separate Sites

1996 • 522 citations

Modification of histidine residues in proteins by reaction with 4-hydroxynonenal.

1992 • 481 citations

Cyclophilin‐D binds strongly to complexes of the voltage‐dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore

1998 • 475 citations

The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore

2000 • 449 citations

Nitric oxide and cell death

1999 • 443 citations

A mitochondrial perspective on cell death

2001 • 430 citations

A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2

1999 • 422 citations

Mitochondrial ADP/ATP Carrier Can Be Reversibly Converted into a Large Channel by Ca²⁺

1996 • 421 citations

Mitochondrial adenine nucleotide translocase is modified oxidatively during aging

1998 • 408 citations

p38 Map Kinase Mediates Bax Translocation in Nitric Oxide–Induced Apoptosis in Neurons

2000 • 391 citations

Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition

1998 • 381 citations

Modification of ion homeostasis by lipid peroxidation: roles in neuronal degeneration and adaptive plasticity

1998 • 344 citations

Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator

2000 • 336 citations

Electrophysiological Study of a Novel Large Pore Formed by Bax and the Voltage-dependent Anion Channel That Is Permeable to Cytochrome c

2000 • 335 citations

Mitochondrial Nitric-oxide Synthase Stimulation Causes Cytochrome c Release from Isolated Mitochondria

1999 • 333 citations

Concentration-dependent Effects of Nitric Oxide on Mitochondrial Permeability Transition and Cytochrome cRelease

2000 • 326 citations

Hepatitis B Virus X Protein Colocalizes to Mitochondria with a Human Voltage-Dependent Anion Channel, HVDAC3, and Alters Its Transmembrane Potential

2000 • 306 citations

On the mechanism by which vascular endothelial cells regulate their oxygen consumption

1999 • 300 citations

Nitric oxide (NO): an effector of apoptosis

1999 • 298 citations

Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transition

1998 • 294 citations

Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis

2000 • 286 citations

Inactivation of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Selective modification of an active-site lysine.

1993 • 281 citations

Adenine Nucleotide Translocase-1, a Component of the Permeability Transition Pore, Can Dominantly Induce Apoptosis

1999 • 278 citations

Control of Mitochondrial Membrane Permeabilization by Adenine Nucleotide Translocator Interacting with HIV-1 Viral Protein R and Bcl-2

2001 • 269 citations

4-Hydroxyhexenal Is a Potent Inducer of the Mitochondrial Permeability Transition

1996 • 251 citations

Nitric oxide induces apoptosis via triggering mitochondrial permeability transition

1997 • 238 citations

Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator

2000 • 228 citations

Apoptosis Control in Syncytia Induced by the HIV Type 1–Envelope Glycoprotein Complex

2000 • 213 citations

Peroxynitrite: reactive, invasive and enigmatic

1999 • 209 citations

Neisseria meningitidisporin PorB interacts with mitochondria and protects cells from apoptosis

2000 • 170 citations

Nitric Oxide–Induced Apoptosis in Human Leukemic Lines Requires Mitochondrial Lipid Degradation and Cytochrome C Release

1999 • 152 citations

Nitric oxide induces tyrosine nitration and release of cytochromecpreceding an increase of mitochondrial transmembrane potential in macrophages

1999 • 135 citations

Nitric Oxide Donors Induce Stress Signaling via Ceramide Formation in Rat Renal Mesangial Cells

1999 • 135 citations

Direct Evidence of Nitric Oxide Presence within Mitochondria

2000 • 127 citations

Activation of the Cell Death Program by Nitric Oxide Involves Inhibition of the Proteasome

1999 • 127 citations

Nitric oxide suppresses human T lymphocyte proliferation through IFN-gamma-dependent and IFN-gamma-independent induction of apoptosis.

1999 • 105 citations

Nitric Oxide Suppresses Human T Lymphocyte Proliferation Through IFN-γ-Dependent and IFN-γ-Independent Induction of Apoptosis

1999 • 77 citations

Human Immunodeficiency Virus Induces a Dual Regulation of Bcl-2, Resulting in Persistent Infection of CD4⁺T- or Monocytic Cell Lines

1998 • 74 citations

Diversity of HIV-1 Vpr Interactions Involves Usage of the WXXF Motif of Host Cell Proteins

1998 • 58 citations

Purification of Mitochondria for Apoptosis Assays

2000 • 58 citations

Fluctuation of the First Loop Facing the Matrix of the Mitochondrial ADP/ATP Carrier Deduced from Intermolecular Cross-Linking of Cys⁵⁶ Residues by Bifunctional Dimaleimides

1998 • 51 citations

Transcription of the adenine nucleotide translocase isoforms in various types of tissues in the rat

1999 • 46 citations

Nitric oxide (NO), a signaling molecule with a killer soul

1999 • 43 citations

Critical Role of Nitric Oxide During the Apoptosis of Peripheral Blood Leukocytes from Patients with AIDS

1999 • 18 citations