Inhibition of the Mitochondrial Permeability Transition by Creatine Kinase Substrates

Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the ‘phosphocreatine circuit’ for cellular energy homeostasis

1992 • 1,958 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition

1999 • 1,509 citations

The mitochondrion in apoptosis: how Pandora's box opens

2001 • 1,035 citations

Transport of Energy in Muscle: The Phosphorylcreatine Shuttle

1981 • 748 citations

The permeability transition pore complex: another view

2002 • 702 citations

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis

1999 • 680 citations

Oxidative Stress, Thiol Reagents, and Membrane Potential Modulate the Mitochondrial Permeability Transition by Affecting Nucleotide Binding to the Adenine Nucleotide Translocase

1997 • 588 citations

Cyclophilin‐D binds strongly to complexes of the voltage‐dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore

1998 • 475 citations

The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore

2000 • 449 citations

Neuroprotective Effects of Creatine and Cyclocreatine in Animal Models of Huntington’s Disease

1998 • 431 citations

Mitochondrial ADP/ATP Carrier Can Be Reversibly Converted into a Large Channel by Ca²⁺

1996 • 421 citations

Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition

1998 • 381 citations

Creatine and Cyclocreatine Attenuate MPTP Neurotoxicity

1999 • 372 citations

Creatine kinase in non-muscle tissues and cells

1994 • 372 citations

Permeabilized cell and skinned fiber techniques in studies of mitochondrial function in vivo

1998 • 366 citations

Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis.

1996 • 353 citations

Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinases

1998 • 342 citations

Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator

2000 • 336 citations

Regulation of the Permeability Transition Pore in Skeletal Muscle Mitochondria

1998 • 321 citations

Untitled

1998 • 286 citations

Adenine Nucleotide Translocase-1, a Component of the Permeability Transition Pore, Can Dominantly Induce Apoptosis

1999 • 278 citations

A Ubiquinone-binding Site Regulates the Mitochondrial Permeability Transition Pore

1998 • 246 citations

The role of creatine kinase in inhibition of mitochondrial permeability transition

1997 • 240 citations

Mitochondrial permeability transition triggers lymphocyte apoptosis.

1996 • 238 citations

Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders

2001 • 232 citations

Protective Effect of the Energy Precursor Creatine Against Toxicity of Glutamate and β‐Amyloid in Rat Hippocampal Neurons

2000 • 221 citations

The mitochondrial ADP/ATP carrier: Structural, physiological and pathological aspects

1998 • 207 citations

Function of M-line-bound creatine kinase as intramyofibrillar ATP regenerator at the receiving end of the phosphorylcreatine shuttle in muscle.

1984 • 193 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. I. Evidence for two separate Me2+ binding sites with opposing effects on the pore open probability.

1993 • 191 citations

The mitochondrial permeability transition

1998 • 185 citations

Commitment to Apoptosis by GD3 Ganglioside Depends on Opening of the Mitochondrial Permeability Transition Pore

1999 • 166 citations

Localization of creatine kinase isoenzymes in myofibrils. I. Chicken skeletal muscle.

1977 • 158 citations

Control of cellular respiration in vivo by mitochondrial outer membrane and by Creatine Kinase. A new speculative hypothesis: possible involvement of mitochondrial-cytoskeleton interactions

1995 • 156 citations

Direct Evidence for the Control of Mitochondrial Respiration by Mitochondrial Creatine Kinase in Oxidative Muscle Cells in Situ

2000 • 155 citations

Reconstituted adenine nucleotide translocase forms a channel for small molecules comparable to the mitochondrial permeability transition pore

1998 • 152 citations

On the mechanisms of neuroprotection by creatine and phosphocreatine

2001 • 141 citations

The molecular structure of mitochondrial contact sites. Their role in regulation of energy metabolism and permeability transition

1998 • 137 citations

Protoporphyrin IX, an endogenous ligand of the peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone.

1994 • 133 citations

Metabolic control and metabolic capacity: two aspects of creatine kinase functioning in the cells

1996 • 130 citations

Creatine supplementation reduces skeletal muscle degeneration and enhances mitochondrial function in mdx mice

2002 • 128 citations

Bioenergetics: Dissecting the role of creatine kinase

1994 • 127 citations

Functional coupling of creatine kin a ses in muscles: Species and tissue specificity

1998 • 126 citations

The mitochondrial aspartate/glutamate and ADP/ATP carrier switch from obligate counterexchange to unidirectional transport after modification by SH-reagents

1990 • 126 citations

A Large Ca²⁺-Dependent Channel Formed by Recombinant ADP/ATP Carrier from Neurospora crassa Resembles the Mitochondrial Permeability Transition Pore

2002 • 124 citations

Creatine supplementation improves intracellular Ca²⁺ handling and survival in mdx skeletal muscle cells

1998 • 123 citations

Functional aspects of the X-ray structure of mitochondrial creatine kinase: a molecular physiology approach.

1998 • 112 citations

The adenine nucleotide translocator in apoptosis

2002 • 112 citations

Magnesium-Ion Modulates the Sensitivity of the Mitochondrial Permeability Transition Pore to Cyclosporine-A and ADP

1994 • 110 citations

Untitled

1998 • 105 citations

Crystal structure of brain‐type creatine kinase at 1.41 Å resolution

1999 • 95 citations

Cytochrome c-Dependent Activation of Caspase-3 by Tumor Necrosis Factor Requires Induction of the Mitochondrial Permeability Transition

2000 • 95 citations

Functional aspects of the X-ray structure of mitochondrial creatine kinase: a molecular physiology approach

1998 • 87 citations

Crystal structure of human ubiquitous mitochondrial creatine kinase

2000 • 78 citations

Coupling of creatine kinase to glycolytic enzymes at the sarcomeric I-band of skeletal muscle: a biochemical study in situ.

2000 • 69 citations

Crystal structure of human ubiquitous mitochondrial creatine kinase

2000 • 67 citations

Advances in developmental biology

1992 • 65 citations

Activity of the Mitochondrial Multiple Conductance Channel Is Independent of the Adenine Nucleotide Translocator

1996 • 63 citations

Expression of functional mitochondrial creatine kinase in liver of transgenic mice

1997 • 61 citations

The utilisation of creatine and its analogues by cytosolic and mitochondrial creatine kinase

1996 • 58 citations

Actions of the creatine analogue β-guanidinopropionic acid on rat heart mitochondria

1994 • 47 citations

Differential expression and localization of brain-type and mitochondrial creatine kinase isoenzymes during development of the chicken retina: Mi-CK as a marker for differentiation of photoreceptor cells

1991 • 47 citations

The mitochondrial carnitine carrier: characterization of SH-groups relevant for its transport function

1992 • 44 citations

Kinetics of assembly and dissociation of the mitochondrial creatine kinase octamer. A fluorescence study

1993 • 39 citations

Functions of Creatine Kinase Isoenzymes in Spermatozoa

1997 • 37 citations

Chimers of Two Fused ADP/ATP Carrier Monomers Indicate a Single Channel for ADP/ATP Transport

2001 • 34 citations

Ligand-selective Modulation of the Permeability Transition Pore by Arginine Modification

2002 • 30 citations

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