Two CD95 (APO-1/Fas) signaling pathways

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Caspases: killer proteases

1997 • 2,440 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Mitochondrial control of apoptosis

1997 • 1,500 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)

1997 • 1,207 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 • 863 citations

Mitochondrial permeability transition is a central coordinating event of apoptosis.

1996 • 857 citations

Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

1997 • 797 citations

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.

1995 • 791 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 • 780 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

1996 • 731 citations

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

1997 • 635 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

1995 • 616 citations

Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2

1992 • 608 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

1994 • 577 citations

The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death

1990 • 533 citations

Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

1996 • 519 citations

CPP32/Apopain Is a Key Interleukin 1β Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis

1996 • 480 citations

Effect of bcl-2 on Fas antigen-mediated cell death.

1993 • 442 citations

FLICE Is Predominantly Expressed as Two Functionally Active Isoforms, Caspase-8/a and Caspase-8/b

1997 • 405 citations

Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

1995 • 391 citations

Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system

1997 • 388 citations

Bcl–2 protects from lethal hepatic apoptosis induced by an ant–Fas antibody in mice

1996 • 370 citations

Cell-specific Induction of Apoptosis by Microinjection of Cytochrome c

1997 • 348 citations

Interaction and Regulation of Subcellular Localization of CED-4 by CED-9

1997 • 345 citations

FLICE Induced Apoptosis in a Cell-free System

1997 • 343 citations

The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.

1996 • 331 citations

Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors

1996 • 321 citations

Interaction between the C. elegans cell-death regulators CED-9 and CED-4

1997 • 304 citations

Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors.

1996 • 300 citations

Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells.

1995 • 293 citations

Overexpression of Bcl-X(L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis.

1997 • 259 citations

Fas-associated Death Domain Protein Interleukin-1β-converting Enzyme 2 (FLICE2), an ICE/Ced-3 Homologue, Is Proximally Involved in CD95- and p55-mediated Death Signaling

1997 • 256 citations

Bcl-2 expression prevents activation of the ICE protease cascade.

1996 • 254 citations

Bcl-2, Bcl-xL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death

1997 • 248 citations

Loss of Function of Cytochrome c in Jurkat Cells Undergoing Fas-mediated Apoptosis

1996 • 225 citations

Bcl-x_Lcan inhibit apoptosis in cells that have undergone Fas-induced protease activation

1997 • 222 citations

Advances in apoptosis research

1997 • 194 citations

A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection.

1996 • 182 citations

Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma.

1995 • 178 citations

Bcl-2 and the Outer Mitochondrial Membrane in the Inactivation of Cytochrome c during Fas-mediated Apoptosis

1997 • 174 citations

Resistance of cultured peripheral T cells towards activation‐induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death‐inducing signaling complex

1997 • 172 citations

Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis.

1996 • 165 citations

Bcl-xL Functions Downstream of Caspase-8 to Inhibit Fas- and Tumor Necrosis Factor Receptor 1-induced Apoptosis of MCF7 Breast Carcinoma Cells

1998 • 160 citations

CD95 (APO-1/Fas) induces activation of SAP kinases downstream of ICE-like proteases.

1996 • 130 citations

Bcl-xL Acts Downstream of Caspase-8 Activation by the CD95 Death-inducing Signaling Complex

1998 • 116 citations

Bcl-2 blocks degranulation but not fas-based cell-mediated cytotoxicity.

1995 • 109 citations

Affinity labeling displays the stepwise activation of ICE-related proteases by Fas, staurosporine, and CrmA-sensitive caspase-8

1997 • 107 citations

Bcl-2 Prevents CD95 (Fas/APO-1)-induced Degradation of Lamin B and Poly(ADP-ribose) Polymerase and Restores the NF-κB Signaling Pathway

1996 • 107 citations

Involvement of caspase-4(-like) protease in Fas-mediated apoptotic pathway

1997 • 97 citations

Cell surface sialylation plays a role in modulating sensitivity towards APO-1-mediated apoptotic cell death.

1995 • 91 citations

The Death Receptors

1999 • 82 citations

Bcl-2 Overexpression Blocks Activation of the Death Protease CPP32/Yama/Apopain

1996 • 64 citations

Apoptosis signaling pathways in normal T cells: differential activity of Bcl-2 and IL-1beta-converting enzyme family protease inhibitors on glucocorticoid- and Fas-mediated cytotoxicity.

1996 • 53 citations

Bcl-2 regulates activation of apoptotic proteases in a cell-free system

1996 • 49 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis???

1990 • 43 citations

bcl-2 protects against Fas-based but not perforin-based T cell-mediated cytolysis

1996 • 34 citations

Bcl-2 prevents activation of CPP32 cysteine protease and cleavage of poly (ADP-ribose) polymerase and U1-70 kD proteins in staurosporine-mediated apoptosis

1997 • 34 citations

Bcl-2 acts upstream of the PARP protease and prevents its activation

1997 • 34 citations