Protective Effect of Amiodarone but NotN-Desethylamiodarone on Postischemic Hearts through the Inhibition of Mitochondrial Permeability Transition

Mitochondria and Apoptosis

1998 • 8,909 citations

Mitochondrial control of cell death

2000 • 3,098 citations

INTRACELLULAR DISTRIBUTION OF ENZYMES

1950 • 1,359 citations

Randomised trial of effect of amiodarone on mortality in patients with left-ventricular dysfunction after recent myocardial infarction: EMIAT

1997 • 1,108 citations

The effect of amiodarone, a new anti-anginal drug, on cardiac muscle

1970 • 553 citations

Apoptosis‐inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis

2000 • 459 citations

Rapid Isolation of Metabolically Active Mitochondria from Rat Brain and Subregions Using Percoll Density Gradient Centrifugation

1990 • 393 citations

The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism

1999 • 304 citations

Amiodarone Pulmonary Toxicity

1988 • 295 citations

Direct effect of Taxol on free radical formation and mitochondrial permeability transition

2001 • 242 citations

Mitochondrial membrane potential and hydroethidine‐monitored superoxide generation in cultured cerebellar granule cells

1997 • 224 citations

Dual effect of amiodarone on mitochondrial respiration. Initial protonophoric uncoupling effect followed by inhibition of the respiratory chain at the levels of complex I and complex II.

1990 • 155 citations

Clinical and Chemical Assessment of Thyroid Function During Therapy With Amiodarone

1984 • 101 citations

Frequency-dependent effects of amiodarone on atrioventricular nodal function and slow-channel action potentials: evidence for calcium channel-blocking activity.

1987 • 94 citations

Comparison of the chronic and acute effects of amiodarone on the calcium and potassium currents in rabbit isolated cardiac myocytes

1996 • 75 citations

Amiodarone-induced lung toxicity. In vitro evidence for the direct toxicity of the drug.

1985 • 71 citations

Disruption of mitochondrial function and cellular ATP levels by amiodarone and N-desethylamiodarone in initiation of amiodarone-induced pulmonary cytotoxicity.

2001 • 61 citations

Cardiac β-adrenoceptor modulation by amiodarone

1983 • 60 citations

Amiodarone Induces CytochromecRelease and Apoptosis through an Iodine-Independent Mechanism¹

2000 • 57 citations

Concentration dependent mitochondrial effect of amiodarone

2003 • 49 citations

Enhanced ADP-ribosylation and its diminution by lipoamide after ischemia-reperfusion in perfused rat heart

1999 • 45 citations

Amiodarone Induces Cytochrome c Release and Apoptosis through an Iodine-Independent Mechanism

2000 • 42 citations

Pulmonary fibrosis induced in the hamster by amiodarone and desethylamiodarone

1989 • 39 citations

Resting, and rate‐dependent depression of of guinea‐pig ventricular action potentials by amiodarone and desethylamiodarone

1987 • 36 citations

Membrane Depolarization of Isolated Rat Liver Mitochondria Attenuates Permeability Transition Pore Opening and Oxidant Production

2002 • 35 citations

Response of alveolar macrophages to amiodarone and desethylamiodarone, in vitro

1990 • 29 citations

Amiodarone-induced disruption of hamster lung and liver mitochondrial function: lack of association with thiobarbituric acid-reactive substance production

1998 • 29 citations

Kinetics of heat shock protein 70 synthesis in the human heart after cold cardioplegic arrest

2002 • 27 citations

Effect of amiodarone (AMD) on the antioxidant enzymes, lipid peroxidation and mitochondrial metabolism

1997 • 26 citations

Differential effects of zidovudine and zidovudine triphosphate on mitochondrial permeability transition and oxidative phosphorylation

1997 • 24 citations

Identification of apoptosis-inducing factor in human coronary artery endothelial cells

2003 • 20 citations

Swelling of mitochondria in cultured rat hippocampal astrocytes is induced by high cytosolic Ca²⁺ load, but not by mitochondrial depolarization

2002 • 19 citations

Sensitive method for the measurement of amiodarone and desethylamiodarone in serum and tissue and its application to dispostion studies

1987 • 18 citations

Desethylamiodarone Prolongation of Cardiac Repolarization is Dependent on Gene Expression: A Novel Antiarrhythmic Mechanism

1998 • 18 citations

N -desethylamiodarone modulates intracellular calcium concentration in endothelial cells

2000 • 17 citations

Protective effects of amiodarone pretreatment on mitochondrial function and high energy phosphates in ischaemic rat heart

1987 • 16 citations

Effects of amiodarone on cardiac function and mitochondrial oxidative phosphorylation during ischemia and reperfusion.

1999 • 15 citations

cAMP and Ca2+Involvement in the Mitochondrial Response of Cultured Fetal Rat Hepatocytes to Adrenaline

1997 • 12 citations

Amiodarone Pretreatment Effects on Ischemic Isovolumic Rat Hearts

1990 • 10 citations

Amiodarone-Induced lung Toxicity

2010 • 9 citations