An inhibitor of Bcl-2 family proteins induces regression of solid tumours

Cell Death

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Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

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Discovering High-Affinity Ligands for Proteins: SAR by NMR

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Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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Structure of Bcl-x _L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

1997 • 1,429 citations

Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix

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Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

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BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death

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Structural biology of the Bcl-2 family of proteins

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Bcl-2-family proteins: the role of the BH3 domain in apoptosis

1998 • 641 citations

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

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The role of Bcl-2 family members in tumorigenesis

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Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3

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Solution structure of the antiapoptotic protein bcl-2

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An informatics approach identifying markers of chemosensitivity in human cancer cell lines.

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Discovery, Characterization, and Structure−Activity Relationships Studies of Proapoptotic Polyphenols Targeting B-Cell Lymphocyte/Leukemia-2 Proteins

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An exact mathematical expression for describing competitive binding of two different ligands to a protein molecule

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Discovery of Small-Molecule Inhibitors of Bcl-2 through Structure-Based Computer Screening

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Oblimersen Bcl-2 Antisense: Facilitating Apoptosis in Anticancer Treatment

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Development of a Potent Bcl-x_LAntagonist Based on α-Helix Mimicry

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Antiapoptotic BCL-2 is required for maintenance of a model leukemia

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Rational Design and Real Time, In-Cell Detection of the Proapoptotic Activity of a Novel Compound Targeting Bcl-XL

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Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs

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Karyoplasmic interaction selection strategy: a general strategy to detect protein-protein interactions in mammalian cells.

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Development of a high-throughput fluorescence polarization assay for Bcl-xL

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Rational Design of Diflunisal Analogues with Reduced Affinity for Human Serum Albumin

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Promise and Problems of Bcl-2 Antisense Therapy

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Expression, Refolding, and Isotopic Labeling of Human Serum Albumin Domains for NMR Spectroscopy

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