Mitochondrial dysfunction is a primary event in renal cell oxalate toxicity

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

Reactive oxygen species in cell signaling

2000 • 2,844 citations

Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury

1990 • 2,639 citations

Biochemical Pathways of Caspase Activation During Apoptosis

1999 • 2,567 citations

The mitochondrial permeability transition

1995 • 2,412 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 2,326 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

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[15] Isolation of liver or kidney mitochondria

1967 • 1,096 citations

Mitochondrial reactive oxygen species in cell death signaling

2002 • 1,009 citations

Mitochondrial permeability transition: a common pathway to necrosis and apoptosis

2003 • 748 citations

[29] Mitochondrial membrane potential monitored by JC-1 dye

1995 • 668 citations

Randall’s plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle

2003 • 554 citations

Equil2: A Basic Computer Program for the Calculation of Urinary Saturation

1985 • 498 citations

Implication of Mitochondrial Hydrogen Peroxide Generation in Ceramide-induced Apoptosis

1997 • 485 citations

Direct Inhibition of Mitochondrial Respiratory Chain Complex III by Cell-permeable Ceramide

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Ceramide: second messenger or modulator of membrane structure and dynamics?

2003 • 424 citations

A methodology for analysis of tissue sulfhydryl components

1972 • 413 citations

Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death.

1999 • 385 citations

Caspase-independent cell death in T lymphocytes

2003 • 368 citations

Protein Complexes Activate Distinct Caspase Cascades in Death Receptor and Stress-Induced Apoptosis

2000 • 332 citations

Mitochondrial dysfunction during hypoxia/reoxygenation and its correction by anaerobic metabolism of citric acid cycle intermediates

2000 • 309 citations

Arachidonic Acid Causes Cell Death through the Mitochondrial Permeability Transition

2001 • 284 citations

Isolation of liver or kidney mitochondria

1967 • 268 citations

Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis

2001 • 267 citations

The Cytotoxicity of Tumor Necrosis Factor Depends on Induction of the Mitochondrial Permeability Transition

1996 • 266 citations

Quantitation of mitochondrial alterations associated with apoptosis

2002 • 257 citations

Arachidonic acid interaction with the mitochondrial electron transport chain promotes reactive oxygen species generation

1999 • 218 citations

Calcium oxalate stone disease: role of lipid peroxidation and antioxidants

2002 • 211 citations

Oxalate toxicity in LLC-PK1 cells: Role of free radicals

1996 • 209 citations

Oxalate and calcium oxalate mediated free radical toxicity in renal epithelial cells: effect of antioxidants

2003 • 192 citations

FREE RADICAL SCAVENGERS, CATALASE AND SUPEROXIDE DISMUTASE PROVIDE PROTECTION FROM OXALATE-ASSOCIATED INJURY TO LLC-PK ₁ AND MDCK CELLS

2000 • 166 citations

Phospholipase A2 Is Necessary for Tumor Necrosis Factor α-induced Ceramide Generation in L929 Cells

1997 • 161 citations

Hyperoxaluric calcium nephrolithiasis

2002 • 160 citations

Crystal-cell interaction and apoptosis in oxalate-associated injury of renal epithelial cells.

1999 • 133 citations

PLA₂dependence of diaphragm mitochondrial formation of reactive oxygen species

2000 • 114 citations

Mitochondrial superoxide production during oxalate-mediated oxidative stress in renal epithelial cells

2002 • 97 citations

Oxalate and calcium oxalate crystals are injurious to renal epithelial cells: results of in vivo and in vitro studies.

1998 • 95 citations

Oxalate Toxicity in Renal Epithelial Cells: Characteristics of Apoptosis and Necrosis

2000 • 94 citations

Oxalate-Induced Initiation of DNA Synthesis in LLC-PK1 Cells: a Line of Renal Epithelial Cells

1994 • 89 citations

Mechanisms Mediating Oxalate-Induced Alterations in Renal Cell Functions

2003 • 84 citations

Mitochondrial sites of hydrogen peroxide production in reperfused rat kidney cortex

1995 • 78 citations

Role of caspases (ICE/CED 3 proteases) in DNA damage and cell death in response to a mitochondrial inhibitor, antimycin A Rapid Communication

1997 • 70 citations

Role of phospholipase A2 in the cytotoxic effects of oxalate in cultured renal epithelial cells

1999 • 66 citations

Oxalate-induced exposure of phosphatidylserine on the surface of renal epithelial cells in culture.

1999 • 60 citations

B Cell Receptor-Stimulated Mitochondrial Phospholipase A2 Activation and Resultant Disruption of Mitochondrial Membrane Potential Correlate with the Induction of Apoptosis in WEHI-231 B Cells

2001 • 59 citations

Ion Exchangers Mediating NaCl Transport in the Renal Proximal Tubule

2002 • 57 citations

Oxalate-Induced Redistribution of Phosphatidylserine in Renal Epithelial Cells

2001 • 55 citations

Oxalate-induced damage to renal tubular cells.

1995 • 49 citations

Renal tubular injury induced by hyperoxaluria: evaluation of apoptotic changes

2001 • 49 citations

Alterations in MDCK and LLC-PK1 cells exposed to oxalate and calcium oxalate monohydrate crystals.

1995 • 47 citations

Oxalate-induced ceramide accumulation in Madin-Darby canine kidney and LLC-PK1 cells

2000 • 41 citations

A cuvette-based fluorometric analysis of mitochondrial membrane potential measured in cultured astrocyte monolayers

2003 • 40 citations

Oxalate binding proteins in calcium oxalate nephrolithiasis

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Detection of Oxidative Stress in Lymphocytes Using Dichlorodihydrofluorescein Diacetate

2003 • 31 citations

Oxalate-induced changes in the viability and growth of human renal epithelial cells.

1999 • 30 citations

The Solubility of Calcium Oxalate in Tissue Culture Media

2001 • 24 citations

Phospholipase A2 mediates immediate early genes in cultured renal epithelial cells: Possible role of lysophospholipid

2000 • 22 citations

Bcl-xL antagonism of BCR-coupled mitochondrial phospholipase A2 signaling correlates with protection from apoptosis in WEHI-231 B cells

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The uptake of oxalate by rat liver and kidney mitochondria.

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Effect of Oxalate on Function of Kidney Mitochondria

1989 • 14 citations

Oxalate-induced changes in renal epithelial cell function: role in stone disease.

2000 • 13 citations