HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells

Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity

2004 • 3,483 citations

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

2005 • 3,292 citations

The Pathophysiology of Mitochondrial Cell Death

2004 • 3,258 citations

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

2000 • 2,064 citations

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

2000 • 1,170 citations

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

1993 • 898 citations

The role of Bcl-2 family members in tumorigenesis

2003 • 536 citations

bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs.

1992 • 487 citations

Evaluation of Combination Chemotherapy

2004 • 364 citations

Patterns of survival in patients with recurrent follicular lymphoma: a 20-year study from a single center.

1995 • 344 citations

Alterations in the apoptotic machinery and their potential role in anticancer drug resistance

2003 • 268 citations

Quantitation of mitochondrial alterations associated with apoptosis

2002 • 257 citations

A Bcr/Abl-independent, Lyn-dependent Form of Imatinib Mesylate (STI-571) Resistance Is Associated with Altered Expression of Bcl-2

2004 • 242 citations

Reversal of Chemoresistance of Lymphoma Cells by Antisense-Mediated Reduction ofbcl-2 Gene Expression

1994 • 190 citations

Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model.

1994 • 187 citations

Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL [(−)-gossypol] against diffuse large cell lymphoma

2005 • 139 citations

Valproic acid inhibits proliferation and induces apoptosis in acute myeloid leukemia cells expressing P-gp and MRP1

2004 • 129 citations

Unbalanced Expression of Bcl-2 Family Proteins in Follicular Lymphoma: Contribution of CD40 Signaling in Promoting Survival

1998 • 126 citations

Detection of apoptosis in live cells by MitoTracker? Red CMXRos and SYTO dye flow cytometry

1997 • 122 citations

Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia

2002 • 121 citations

Therapeutic potential of antisense Bcl‐2 as a chemosensitizer for cancer therapy

2004 • 112 citations

Eradication of human non-Hodgkin's lymphoma in SCID mice by BCL-2 antisense oligonucleotides combined with low-dose cyclophosphamide.

2000 • 107 citations

Simultaneous modulation of multidrug resistance and antiapoptotic cellular defense by MDR1 and BCL-2 targeted antisense oligonucleotides enhances the anticancer efficacy of doxorubicin.

2003 • 100 citations

Regulation of 17-AAG—induced apoptosis: role of Bcl-2, Bcl-xL, and Bax downstream of 17-AAG—mediated down-regulation of Akt, Raf-1, and Src kinases

2003 • 95 citations

Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis Is Inhibited by Bcl-2 but Restored by the Small Molecule Bcl-2 Inhibitor, HA 14-1, in Human Colon Cancer Cells

2004 • 95 citations

Bcl-2 Inhibitors Sensitize Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis by Uncoupling of Mitochondrial Respiration in Human Leukemic CEM Cells

2004 • 82 citations

Promises and challenges of targeting Bcl-2 anti-apoptotic proteins for cancer therapy

2004 • 81 citations

Bcl-2/bcl-xL Bispecific Antisense Treatment Sensitizes Breast Carcinoma Cells to Doxorubicin, Paclitaxel and Cyclophosphamide

2002 • 80 citations

Inactivation of MAP kinase signalling in Myc transformed cells and rescue by LiCl inhibition of GSK3.

2005 • 79 citations

Bcl-2 family members in childhood acute lymphoblastic leukemia: relationships with features at presentation, in vitro and in vivo drug response and long-term clinical outcome

1999 • 78 citations

Chemosensitization of myeloma plasma cells by an antisense-mediated downregulation of Bcl-2 protein

2003 • 77 citations

HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death

2003 • 69 citations

The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical–dependent and Jun NH2-terminal kinase–dependent mechanism

2004 • 67 citations

Bax expression correlates with cellular drug sensitivity to doxorubicin, cyclophosphamide and chlorambucil but not fludarabine, cladribine or corticosteroids in B cell chronic lymphocytic leukemia

2002 • 66 citations

The apoptotic effect of HA14-1, a Bcl-2-interacting small molecular compound, requires Bax translocation and is enhanced by PK11195.

2002 • 54 citations

Potentiation of dexamethasone-, paclitaxel-, and Ad-p53–induced apoptosis by Bcl-2 antisense oligodeoxynucleotides in drug-resistant multiple myeloma cells

2003 • 50 citations

Mechanism of apoptosis and determination of cellular fate in chromium(VI)-exposed populations of telomerase-immortalized human fibroblasts.

2001 • 49 citations

Antisense oligodeoxyribonucleotide down-regulation of bcl-2 gene expression inhibits growth of the low-grade non-Hodgkin's lymphoma cell line WSU-FSCCL.

1995 • 45 citations

G3139, a Bcl-2 antisense oligodeoxynucleotide, induces clinical responses in VAD refractory myeloma

2004 • 44 citations

Follicular Lymphoma Cell Lines, an In Vitro Model for Antigenic Selection and Cytokine‐Mediated Growth Regulation of Germinal Centre B Cells

2003 • 41 citations

Novel multiparameter flow cytometry assay using Syto16 for the simultaneous detection of early apoptosis and apoptosis‐corrected P‐glycoprotein function in clinical samples

2003 • 38 citations

Inhibition of Bcl-xL expression sensitizes T-cell acute lymphoblastic leukemia cells to chemotherapeutic drugs

2002 • 35 citations

Apoptotic Induction in Transformed Follicular Lymphoma Cells by Bcl-2 Downregulation

1998 • 35 citations

Preclinical evaluation of antisense bcl‐2 as a chemosensitizer for patients with gastric carcinoma

2004 • 34 citations

Bcl-2 has differing effects on the sensitivity of breast cancer cells depending on the antineoplastic drug used

2002 • 34 citations

Combined treatment of Bcl‐2 antisense oligodeoxynucleotides (G3139), p‐glycoprotein inhibitor (PSC833), and sterically stabilized liposomal doxorubicin suppresses growth of drug‐resistant growth of drug‐resistant breast cancer in severely combined immunodeficient mice

2003 • 23 citations

Cellular Pharmacology of P-ethoxy Antisense Oligonucleotides Targeted to Bcl-2 in a Follicular Lymphoma Cell Line

2003 • 15 citations

Induction of apoptosis and bcl-2 expression in acute lymphoblastic leukaemia and non-Hodgkin's lymphoma in children

2001 • 5 citations