Protein kinase Cɛ interacts with Bax and promotes survival of human prostate cancer cells

Structure of Bax

2000 • 1,066 citations

Bax in Murine Thymus Is a Soluble Monomeric Protein That Displays Differential Detergent-induced Conformations

1998 • 508 citations

Bcl-2 and Bax function independently to regulate cell death

1997 • 397 citations

Adaptor proteins in protein kinase C-mediated signal transduction

2001 • 352 citations

14-3-3 Interacts Directly with and Negatively Regulates Pro-apoptotic Bax

2003 • 344 citations

Bax and other pro-apoptotic Bcl-2 family "killer-proteins" and their victim the mitochondrion

2001 • 326 citations

Integrin-Mediated Survival Signals Regulate the Apoptotic Function of Bax through Its Conformation and Subcellular Localization

2000 • 293 citations

Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: A general mechanism to accumulate effector cells in inflammation

1999 • 277 citations

Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function.

1996 • 252 citations

Role of PI3K Signaling in Survival and Progression of LNCaP Prostate Cancer Cells to the Androgen Refractory State

2001 • 251 citations

Functional Proteomic Analysis of Protein Kinase C ε Signaling Complexes in the Normal Heart and During Cardioprotection

2001 • 201 citations

Involvement of Protein Kinase C δ (PKCδ) in Phorbol Ester-induced Apoptosis in LNCaP Prostate Cancer Cells

2000 • 200 citations

The G2/M Regulator 14-3-3ς Prevents Apoptosis through Sequestration of Bax

2001 • 154 citations

Silibinin inhibits constitutive and TNFα-induced activation of NF-κB and sensitizes human prostate carcinoma DU145 cells to TNFα-induced apoptosis

2002 • 153 citations

Protein Kinase C Isoenzyme Patterns Characteristically Modulated in Early Prostate Cancer

1999 • 144 citations

Temporal relationship between cytochrome c release and mitochondrial swelling during UV-induced apoptosis in living HeLa cells

2001 • 130 citations

Failure of hormone therapy in prostate cancer involves systematic restoration of androgen responsive genes and activation of rapamycin sensitive signaling

2001 • 125 citations

Molecular Analysis of the Interactions between Protein Kinase C-ε and Filamentous Actin

1998 • 120 citations

Protein Kinase C-ε Promotes Survival of Lung Cancer Cells by Suppressing Apoptosis through Dysregulation of the Mitochondrial Caspase Pathway

2002 • 103 citations

Structure of the C2 domain from novel protein kinase Cϵ. A membrane binding model for Ca2+-independent C2 domains

2001 • 100 citations

Protein Kinase C ε Signaling Complexes Include Metabolism- and Transcription/Translation-related Proteins

2002 • 98 citations

Protein kinase Cδ amplifies ceramide formation via mitochondrial signaling in prostate cancer cells

2002 • 98 citations

Developmental regulation of Bcl-2 family protein expression in the involuting mammary gland

1999 • 96 citations

Diacylglycerol (DAG)-lactones, a New Class of Protein Kinase C (PKC) Agonists, Induce Apoptosis in LNCaP Prostate Cancer Cells by Selective Activation of PKCα

2002 • 94 citations

Proteolytic Activation of Protein Kinase C-ε by Caspase-mediated Processing and Transduction of Antiapoptotic Signals

2002 • 82 citations

c-Jun N-Terminal Kinase Mediates Apoptotic Signaling Induced byN-(4-Hydroxyphenyl)retinamide

1999 • 78 citations

Androgen Receptor Up-Regulates Insulin-Like Growth Factor Binding Protein-5 (IGFBP-5) Expression in a Human Prostate Cancer Xenograft*

1999 • 73 citations

Androgen Receptor Regulation of G1 Cyclin and Cyclin‐Dependent Kinase Function in the CWR22 Human Prostate Cancer Xenograft

2001 • 69 citations

Retinoblastoma Protein-dependent Growth Signal Conflict and Caspase Activity Are Required for Protein Kinase C-signaled Apoptosis of Prostate Epithelial Cells

1997 • 58 citations

C-Jun N-terminal kinase is required for phorbol ester- and thapsigargin-induced apoptosis in the androgen responsive prostate cancer cell line LNCaP

2002 • 52 citations

Regulation of Caveolin-1 Expression and Secretion by a Protein Kinase Cε Signaling Pathway in Human Prostate Cancer Cells

2002 • 44 citations

Molecular conformation dictates signaling module formation: example of PKCε and Src tyrosine kinase

2002 • 43 citations

The Protein Kinase C Activator, Phorbol Ester, Elicits Disparate Functional Responses in Androgen-Sensitive and Androgen-Independent Human Prostatic Cancer Cells

1998 • 40 citations

Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogues as potential inhibitors of prostate cancer cell growth

2001 • 32 citations

Ceramide-induced cell death in the prostate cancer cell line LNCaP has both necrotic and apoptotic features

2001 • 29 citations

Rb activation and repression of c-myc transcription precede apoptosis of human prostate epithelial cells

2001 • 25 citations

Regulation of the expression of protein kinase C isoenzymes in rat ventral prostate: effects of age, castration and flutamide treatment

2002 • 11 citations