Direct Activation of Mitochondrial Apoptosis Machinery by c-Jun N-terminal Kinase in Adult Cardiac Myocytes

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Mitochondrial control of cell death

2000 • 3,098 citations

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

2000 • 1,703 citations

BCL-2 Is Phosphorylated and Inactivated by an ASK1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G₂/M

1999 • 997 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

Construction of adenovirus vectors through Cre-lox recombination

1997 • 807 citations

Fas Ligand-Induced Apoptosis

1999 • 778 citations

DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1

1998 • 726 citations

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

1999 • 676 citations

Signaling Pathways in Reactive Oxygen Species–Induced Cardiomyocyte Apoptosis

1999 • 574 citations

Production of Nitric Oxide by Mitochondria

1998 • 573 citations

Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia

1999 • 544 citations

Translocation of SAPK/JNK to Mitochondria and Interaction with Bcl-xL in Response to DNA Damage

2000 • 421 citations

Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53.

1997 • 375 citations

Morphological and Molecular Characterization of Adult Cardiomyocyte Apoptosis During Hypoxia and Reoxygenation

2000 • 312 citations

Novel Role for JNK as a Stress-activated Bcl2 Kinase

2001 • 290 citations

pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine.

1990 • 256 citations

Preservation of Mitochondrial Structure and Function after Bid- or Bax-Mediated Cytochrome c Release

2000 • 244 citations

The c-Jun N-Terminal Kinase Cascade Plays a Role in Stress-Induced Apoptosis in Jurkat Cells by Up-Regulating Fas Ligand Expression

1998 • 238 citations

Stress-Induced Fas Ligand Expression in T Cells Is Mediated through a MEK Kinase 1-Regulated Response Element in the Fas Ligand Promoter

1998 • 193 citations

MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes

1999 • 134 citations

Cytoprotection by Jun Kinase During Nitric Oxide–Induced Cardiac Myocyte Apoptosis

2001 • 123 citations

Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis

1999 • 108 citations

Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro

2000 • 101 citations

Cocaine induces apoptosis in fetal myocardial cells through a mitochondria-dependent pathway.

2000 • 88 citations

Proinflammatory consequences of transgenic Fas ligand expression in the heart

2000 • 88 citations

Redox Regulation of Cardiomyocyte Survival and Death

2001 • 58 citations

Interference with gene expression induces rapid apoptosis in p53-null T lymphoma cells

1999 • 2 citations