β-Carbolines induce apoptosis in cultured cerebellar granule neurons via the mitochondrial pathway
Data up to Jan 2025
Total Citations Per Year
Abstract
References (50)
A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding
1976 • 225,752 citations
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
1976 • 200,127 citations
Mitochondria and Apoptosis
1998 • 8,909 citations
Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
1999 • 2,796 citations
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
1999 • 2,157 citations
Apoptosis control by death and decoy receptors
1999 • 1,296 citations
Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane
2000 • 1,150 citations
The mitochondrion in apoptosis: how Pandora's box opens
2001 • 1,035 citations
Many cuts to ruin: a comprehensive update of caspase substrates
2003 • 1,021 citations
JC‐1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess ΔΨ changes in intact cells: implications for studies on mitochondrial functionality during apoptosis
1997 • 982 citations
The molecular biology of apoptosis.
1996 • 963 citations
Growth and cultivation of dissociated neurons and glial cells from embryonic chick, rat and human brain in flask cultures.
1972 • 760 citations
BAX Is Required for Neuronal Death after Trophic Factor Deprivation and during Development
1996 • 745 citations
Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions
1998 • 645 citations
The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet
2002 • 628 citations
Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors.
1980 • 542 citations
Apoptosis driven by IP3-linked mitochondrial calcium signals
1999 • 492 citations
Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria
2002 • 491 citations
Peripheral benzodiazepine receptors and mitochondrial function
2002 • 447 citations
Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization
2003 • 434 citations
Different responses of astrocytes and neurons to nitric oxide: The role of glycolytically generated ATP in astrocyte protection
2001 • 406 citations
The anti‐epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA‐ and glycine‐gated currents
2002 • 329 citations
Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli
2002 • 312 citations
Apoptosomes: engines for caspase activation
2002 • 306 citations
Involvement of a Caspase‐3‐Like Cysteine Protease in 1‐Methyl‐4‐Phenylpyridinium‐Mediated Apoptosis of Cultured Cerebellar Granule Neurons
1997 • 161 citations
Caspase-Dependent and -Independent Cell Death Pathways in Primary Cultures of Mesencephalic Dopaminergic Neurons after Neurotoxin Treatment
2003 • 137 citations
1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide
2003 • 121 citations
Apoptotic mechanisms and antiapoptotic therapy in the MPTP model of Parkinson's disease
2003 • 114 citations
Endogenously Occurring β‐Carboline Induces Parkinsonism in Nonprimate Animals: A Possible Causative Protoxin in Idiopathic Parkinson's Disease
1998 • 110 citations
The peripheral benzodiazepine receptors: a review.
2000 • 104 citations
Molecular mechanisms of glutamate neurotoxicity in mixed cultures of NT2‐derived neurons and astrocytes: Protective effects of coenzyme Q10
2003 • 87 citations
Diazepam Promotes ATP Recovery and Prevents Cytochrome c Release in Hippocampal Slices After In Vitro Ischemia
2000 • 82 citations
The neurotoxicity of 1-methyl-4-phenylpyridinium in cultured cerebellar granule cells
1989 • 81 citations
beta-Carbolinium cations, endogenous MPP plus analogs, in the lumbar cerebrospinal fluid of patients with Parkinson's disease
1995 • 81 citations
1‐Methyl‐4‐phenylpyridinium accumulates in cerebellar granule neurons via organic cation transporter 3
2003 • 77 citations
Astrocytes Are More Resistant Than Neurons to the Cytotoxic Effects of Increased [Zn2+]i
2000 • 76 citations
Caspase Inhibitors Attenuate 1-Methyl-4-Phenylpyridinium Toxicity in Primary Cultures of Mesencephalic Dopaminergic Neurons
2002 • 74 citations
Isolation and identification in bovine cerebral cortex of n-butyl beta-carboline-3-carboxylate, a potent benzodiazepine binding inhibitor.
1986 • 71 citations
Elk-1 associates with the mitochondrial permeability transition pore complex in neurons
2006 • 52 citations
Visualisation of mitochondria in living neurons with single- and two-photon fluorescence laser microscopy
2001 • 49 citations
Vitamin E blocks early events induced by 1‐methyl‐4‐phenylpyridinium (MPP+) in cerebellar granule cells
2003 • 47 citations
Potassium-induced release of neuronotoxic activity by astrocytes
1987 • 39 citations
Potential neurotoxic “agents provocateurs” in Parkinson's disease
2002 • 38 citations
Chapter 21 Analysis of mitochondria during cell death
2001 • 30 citations
Mechanisms of MPP + incorporation into cerebellar granule cells
2001 • 25 citations
Mechanisms of cell death by deprivation of depolarizing conditions during cerebellar granule neurons maturation
2003 • 23 citations
GABAA receptor activation triggers a Cl− conductance increase and a K+ channel blockade in cerebellar granule cells
1997 • 22 citations
β-Carbolines induce apoptotic death of cerebellar granule neurones in culture
1996 • 13 citations
Astroglia‐released factor shows similar effects as benzodiazepine inverse agonists
1994 • 11 citations
Determination of n-butyl-β-carboline-3-carboxylate in aqueous brain extracts
1988 • 1 citations