Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Biogenesis of Mitochondria

1988 • 1,396 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

The biochemistry of programmed cell death

1995 • 997 citations

Flow Cytometric Analysis of Respiratory Burst Activity in Phagocytes With Hydroethidine and 2′,7′-Dichlorofluorescin

1990 • 869 citations

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.

1988 • 846 citations

Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase

1990 • 738 citations

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

1989 • 699 citations

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

1991 • 675 citations

Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis.

1995 • 598 citations

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

1994 • 577 citations

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1994 • 561 citations

Programmed cell death and Bcl-2 protection in the absence of a nucleus.

1994 • 560 citations

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor.

1993 • 535 citations

Cell nucleus and DNA fragmentation are not required for apoptosis.

1994 • 436 citations

The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A

1991 • 368 citations

Immunophilin-sensitive protein phosphatase action in cell signaling pathways

1992 • 338 citations

Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition

1993 • 294 citations

Protective Effect of N-Acetylcysteine in Tumor Necrosis Factor-α-Induced Apoptosis in U937 Cells: The Role of Mitochondria

1995 • 274 citations

The ADP-ATP Translocation in mitochondria, a membrane potential controlled transport

1980 • 262 citations

The reconstituted ADP/ATP carrier activity has an absolute requirement for cardiolipin as shown in cysteine mutants.

1994 • 210 citations

Regulation of the permeability transition pore, a voltage-dependent mitochondrial channel inhibited by cyclosporin A

1994 • 208 citations

Glucocorticoid-mediated control of the activation and clonal deletion of peripheral T cells in vivo.

1993 • 163 citations

Mitochondrial perturbations define lymphocytes undergoing apoptotic depletion in vivo

1995 • 148 citations

Protoporphyrin IX, an endogenous ligand of the peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone.

1994 • 133 citations

Novel mechanisms in chemically induced hepatotoxicity ¹

1994 • 108 citations

The presence of two classes of high‐affinity cyclosporin A binding sites in mitochondria

1990 • 104 citations

Growth and senescence of Medicago truncatula cultured cells are associated with characteristic mitochondrial morphology

2006 • 97 citations

Partial inhibition by cyclosporin A of the swelling of liver mitochondria in vivo and in vitro induced by sub-micromolar [Ca2+], but not by butyrate. Evidence for two distinct swelling mechanisms

1990 • 88 citations

Ca2+ depletion prevents anoxic death of hepatocytes by inhibiting mitochondrial permeability transition

1995 • 79 citations

Identification of Genes Induced during Apoptosis in T Lymphocytes

1994 • 71 citations

Importance of Loops of Mitochondrial ADP/ATP Carrier for Its Transport Activity Deduced from Reactivities of its Cysteine Residues with the Sulfhydryl Reagent Eosin-5-maleimide

1994 • 68 citations

Topography of the membrane-bound ADP/ATP carrier assessed by enzymic proteolysis

1992 • 61 citations

Evidence for the Involvement of a Membrane‐Associated Cyclosporin‐A‐Binding Protein in the Ca²⁺‐Activated Inner Membrane Pore of Heart Mitochondria

1995 • 53 citations

Molecular Mechanisms of Immunosuppression by Cyclosporins

1993 • 52 citations

Elucidation of the chemical structure of bongkrekic acid—I

1970 • 45 citations

On the mechanism by which Mg2+ and adenine nucleotides restore membrane potential in rat liver mitochondria deenergized by Ca2+ and phosphate

1983 • 38 citations

Flow cytometric analysis of altered mononuclear cell transmembrane potential induced by cyclosporin

1993 • 22 citations