The central executioners of apoptosis: caspases or mitochondria?

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Caspases: killer proteases

1997 • 2,440 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

Mitochondrial control of apoptosis

1997 • 1,500 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

The biochemistry of programmed cell death

1995 • 997 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

1998 • 872 citations

Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium Signals

1997 • 739 citations

The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

1998 • 700 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak

1997 • 555 citations

The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death

1997 • 470 citations

Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

1995 • 467 citations

Requirement for GD3 Ganglioside in CD95- and Ceramide-Induced Apoptosis

1997 • 428 citations

The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death

1996 • 420 citations

DCP-1, a Drosophila Cell Death Protease Essential for Development

1997 • 312 citations

Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death.

1996 • 281 citations

Cosuppression in Drosophila: Gene Silencing of Alcohol dehydrogenase by white-Adh Transgenes Is Polycomb Dependent

1997 • 245 citations

Target Cell Lysis by CTL Granule Exocytosis Is Independent of ICE/Ced-3 Family Proteases

1997 • 237 citations

Bcl-x_Lcan inhibit apoptosis in cells that have undergone Fas-induced protease activation

1997 • 222 citations

E4orf4, a Novel Adenovirus Death Factor That Induces p53-independent Apoptosis by a Pathway That Is Not Inhibited by zVAD-fmk

1998 • 214 citations

Cytokine Response Modifier A (CrmA) Inhibits Ceramide Formation in Response to Tumor Necrosis Factor (TNF)-α: CrmA and Bcl-2 Target Distinct Components in the Apoptotic Pathway

1997 • 210 citations

Establishment of a Cell-Free System of Neuronal Apoptosis: Comparison of Premitochondrial, Mitochondrial, and Postmitochondrial Phases

1997 • 188 citations

Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death

1998 • 179 citations

Apoptosis by a cytosolic extract from Fas-activated cells.

1995 • 167 citations

Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe.

1997 • 160 citations

Commitment to cell death measured by loss of clonogenicity is separable from the appearance of apoptotic markers

1998 • 121 citations

CED-4 induces chromatin condensation in Schizosaccharomyces pombe and is inhibited by direct physical association with CED-9

1997 • 120 citations

Bcl-xL Acts Downstream of Caspase-8 Activation by the CD95 Death-inducing Signaling Complex

1998 • 116 citations

Requirement of the Caspase-3/CPP32 Protease Cascade for Apoptotic Death following Cytokine Deprivation in Hematopoietic Cells

1997 • 103 citations

CD4+ CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway.

1997 • 86 citations

Facing death in the fly: genetic analysis of apoptosis in Drosophila

1997 • 82 citations

Perspectives on the mitochondrial multiple conductance channel

1996 • 64 citations

Cyclosporin A‐sensitive release of Ca²⁺from mitochondria in intact thymocytes

1997 • 9 citations