Solution Structure of the BHRF1 Protein From Epstein-Barr Virus, a Homolog of Human Bcl-2

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Protein backbone angle restraints from searching a database for chemical shift and sequence homology.

1999 • 2,966 citations

Protein NMR Spectroscopy: Principles and Practice

1995 • 1,642 citations

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

2002 • 1,617 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Structure of Bcl-x _L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

1997 • 1,429 citations

Protein NMR Spectroscopy. Principles and Practice

1997 • 974 citations

Gradient-Enhanced Triple-Resonance Three-Dimensional NMR Experiments with Improved Sensitivity

1994 • 814 citations

14-3-3 Proteins and Survival Kinases Cooperate to Inactivate BAD by BH3 Domain Phosphorylation

2000 • 634 citations

Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death.

1993 • 602 citations

Stereospecific nuclear magnetic resonance assignments of the methyl groups of valine and leucine in the DNA-binding domain of the 434 repressor by biosynthetically directed fractional carbon-13 labeling

1989 • 567 citations

Ribbon models of macromolecules

1987 • 519 citations

Solution structure of the antiapoptotic protein bcl-2

2001 • 433 citations

Rationale for Bcl‐X_L/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

2000 • 388 citations

Heteronuclear three-dimensional nmr spectroscopy. A strategy for the simplification of homonuclear two-dimensional NMR spectra

1988 • 382 citations

An exact mathematical expression for describing competitive binding of two different ligands to a protein molecule

1995 • 357 citations

Viral homologs of BCL-2: role of apoptosis in the regulation of virus infection

2002 • 280 citations

Three-dimensional NOESY-HMQC spectroscopy of a 13C-labeled protein

1990 • 212 citations

Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms

1999 • 199 citations

Identification of an Epstein-Barr virus early gene encoding a second component of the restricted early antigen complex

1987 • 183 citations

The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity

2003 • 170 citations

Epstein-Barr Virus Encodes a Novel Homolog of thebcl-2Oncogene That Inhibits Apoptosis and Associates with Bax and Bak

1999 • 158 citations

Antiapoptotic Herpesvirus Bcl-2 Homologs Escape Caspase-Mediated Conversion to Proapoptotic Proteins

2000 • 137 citations

Herpesvirus saimiri encodes a functional homolog of the human bcl-2 oncogene

1997 • 131 citations

BHRF1, the Epstein-Barr virus gene with homology to Bc12, is dispensable for B-lymphocyte transformation and virus replication

1991 • 128 citations

NMR structure determination of proteins and protein complexes larger than 20 kDa

1998 • 126 citations

Solution Structure of Human BCL-w

2003 • 123 citations

Identification of the In Vivo Role of a Viral bcl-2

2002 • 122 citations

Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus

2002 • 120 citations

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

2000 • 119 citations

Viral interference with apoptosis

1998 • 105 citations

Epstein-Barr Virus BALF1 Is a BCL-2-Like Antagonist of the Herpesvirus Antiapoptotic BCL-2 Proteins

2002 • 94 citations

BHRF1 of Epstein-Barr virus, which is homologous to human proto-oncogene bcl2, is not essential for transformation of B cells or for virus replication in vitro

1992 • 79 citations

BHRF1, a viral homologue of the Bcl-2 oncogene, is conserved at both the sequence and functional level in different Epstein-Barr virus isolates.

1997 • 63 citations

Unmasking of a proliferation-restraining activity of the anti-apoptosis protein EBV BHRF1.

1996 • 56 citations

Functional Differences between BHRF1, the Epstein-Barr Virus-Encoded Bcl-2 Homologue, and Bcl-2 in Human Epithelial Cells

1998 • 40 citations

The Cellular Protein PRA1 Modulates the Anti-apoptotic Activity of Epstein-Barr Virus BHRF1, a Homologue of Bcl-2, through Direct Interaction

2001 • 34 citations

Epstein–Barr virus BHRF1 functions downstream of Bid cleavage and upstream of mitochondrial dysfunction to inhibit TRAIL-induced apoptosis in BJAB cells

2002 • 33 citations

Epstein-Barr virus and apoptosis: viral mimicry of cellular pathways

1999 • 25 citations

BHRF1 Is Highly Conserved in Primate Virus Analogues of Epstein-Barr Virus

2001 • 13 citations