Human Hepatitis B Virus-X Protein Alters Mitochondrial Function and Physiology in Human Liver Cells

Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction

1992 • 5,105 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein

2002 • 894 citations

Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation–reduction state

2002 • 656 citations

Bcl-xL Prevents Cell Death following Growth Factor Withdrawal by Facilitating Mitochondrial ATP/ADP Exchange

1999 • 496 citations

Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis

2003 • 468 citations

Chapter 26 Preparation and Characterization of Mitochondria and Submitochondrial Particles of Rat Liver and Liver-Derived Tissues

1978 • 451 citations

The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore

2000 • 449 citations

Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase.

1996 • 381 citations

Mitochondrially Associated Hepatitis B Virus X Protein Constitutively Activates Transcription Factors STAT-3 and NF-κB via Oxidative Stress

2001 • 310 citations

Hepatitis B Virus X Protein Colocalizes to Mitochondria with a Human Voltage-Dependent Anion Channel, HVDAC3, and Alters Its Transmembrane Potential

2000 • 306 citations

Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor α

1997 • 302 citations

Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls.

1995 • 286 citations

Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation.

1995 • 263 citations

Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein

1999 • 243 citations

Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma.

1997 • 228 citations

Activation of Src Family Kinases by Hepatitis B Virus HBx Protein and Coupled Signaling to Ras

1997 • 228 citations

Hepatitis B Virus X Protein Is both a Substrate and a Potential Inhibitor of the Proteasome Complex

1999 • 227 citations

Ethanol stimulates the production of reactive oxygen species at mitochondrial complexes I and III

1999 • 218 citations

Assay conditions for the mitochondrial NADH:coenzyme Q oxidoreductase

1993 • 207 citations

Diphenyleneiodonium inhibits reduction of iron-sulfur clusters in the mitochondrial NADH-ubiquinone oxidoreductase (Complex I).

1994 • 199 citations

The Hepatitis B Virus-X Protein Activates a Phosphatidylinositol 3-Kinase-dependent Survival Signaling Cascade

2001 • 181 citations

Short-chain fatty acid-initiated cell cycle arrest and apoptosis of colonic epithelial cells is linked to mitochondrial function.

1997 • 181 citations

p53-independent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitro

1998 • 173 citations

The U _S 3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins

2001 • 160 citations

Hepatitis B Virus X Protein Induces Cell Death by Causing Loss of Mitochondrial Membrane Potential

2003 • 156 citations

The Hepatitis B Virus HBx Protein Inhibits Caspase 3 Activity

1998 • 130 citations

One-step purification from Escherichia coli of complex II (succinate: ubiquinone oxidoreductase) associated with succinate-reducible cytochrome b556

1989 • 119 citations

Mitochondrial redox signaling during apoptosis.

1999 • 107 citations

Regulation of the mitochondrial ATP-synthase in health and disease

2003 • 104 citations

The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway

1998 • 96 citations

Interaction of genistein with the mitochondrial electron transport chain results in opening of the membrane transition pore

2002 • 95 citations

Human T-cell leukemia virus type I tax protein induces the expression of anti-apoptotic gene Bcl-xL in human T-cells through nuclear factor-kappaB and c-AMP responsive element binding protein pathways.

2001 • 95 citations

Mitochondrial Superoxide Radical Formation is Controlled by Electron Bifurcation to the High and Low Potential Pathways

2002 • 94 citations

Successful interferon therapy reverses enhanced hepatic iron accumulation and lipid peroxidation in chronic hepatitis C

2000 • 91 citations

Hepatitis B virus-X protein upregulates the expression of p21wafl/cipl and prolongs G1→S transition via a p53-independent pathway in human hepatoma cells

2000 • 87 citations

Mitochondrial calcium release induced by prooxidants

1993 • 86 citations

Qualitative and comparative nature of mitochondrial translation products in mammalian cells

1982 • 43 citations

Functional Analysis of Hepatitis B Virus Transactivator X: Implication of the Leucine Zipper-like Region and C-Terminal Seven Conserved Amino Acids in Functional Regions

1993 • 24 citations

Establishment and characterization of cell lines constitutively expressing hepatitis B virus X-protein

1998 • 20 citations

Identification of Differentially Expressed Genes in Human Hepatoblastoma Cell Line (HepG2) and HBV-X Transfected Hepatoblastoma Cell Line (HepG2-4X)

1998 • 5 citations

Mitochondria: inducers and targets of oxidative stress

2003 • 3 citations

Docosahexaenoic acid accumulation in the prenatal brain: a purported role in combating oxidative stress

2003 • 2 citations