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1996 • 494 citations

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1996 • 425 citations

The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release

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Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses

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Mice lacking secretory phospholipase A2 show altered apoptosis and differentiation with Helicobacter felis infection

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Low pH Activates the Vacuolating Toxin of Helicobacter pylori, Which Becomes Acid and Pepsin Resistant

1995 • 217 citations

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1993 • 205 citations

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Acid-induced Dissociation of VacA, the Helicobacter pylori Vacuolating Cytotoxin, Reveals Its Pattern of Assembly

1997 • 199 citations

Helicobacter pylori alters gastric epithelial cell cycle events and gastrin secretion in Mongolian gerbils

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Vacuolating Cytotoxin of Helicobacter pylori Induces Apoptosis in the Human Gastric Epithelial Cell Line AGS

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Activation of Helicobacter pylori VacA Toxin by Alkaline or Acid Conditions Increases Its Binding to a 250-kDa Receptor Protein-tyrosine Phosphatase β

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1996 • 156 citations

Essential Role of a GXXXG Motif for Membrane Channel Formation by Helicobacter pylori Vacuolating Toxin

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A Dominant Negative Mutant of Helicobacter pyloriVacuolating Toxin (VacA) Inhibits VacA-induced Cell Vacuolation

1999 • 131 citations

Helicobacter pylori toxin VacA induces vacuole formation by acting in the cell cytosol

1997 • 123 citations

A 12-Amino-Acid Segment, Present in Type s2 but Not Type s1 Helicobacter pylori VacA Proteins, Abolishes Cytotoxin Activity and Alters Membrane Channel Formation

2001 • 123 citations

Potentiation of Helicobacter pylori Vacuolating Toxin Activity by Nicotine and Other Weak Bases

1992 • 118 citations

Identification of the Minimal Intracellular Vacuolating Domain of the Helicobacter pylori Vacuolating Toxin

1999 • 110 citations

Effects of ATPase inhibitors on the response of HeLa cells to Helicobacter pylori vacuolating toxin

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In search of the Helicobacter pylori VacA mechanism of action

2001 • 97 citations

A novel apoptosis‐inducing protein from Helicobacter pylori

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Acid activation of Helicobacter pylori vacuolating cytotoxin (VacA) results in toxin internalization by eukaryotic cells

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The Acid Activation ofHelicobacter pyloriToxin VacA: Structural and Membrane Binding Studies

1998 • 90 citations

Plasma Membrane Cholesterol Modulates Cellular Vacuolation Induced by the Helicobacter pylori Vacuolating Cytotoxin

2002 • 78 citations

Inhibition of the vacuolating and anion channel activities of the VacA toxin of Helicobacter pylori

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Carboxy-Terminal Proteolytic Processing of Helicobacter pylori Vacuolating Toxin

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Character and origin of vacuoles induced in mammalian cells by the cytotoxin of Helicobacter pylori

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Assays for Cytochrome c Release from Mitochondria during Apoptosis

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Enhanced Disease Severity inHelicobacter pylori-Infected Mice Deficient in Fas Signaling

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The vacuolar ATPase proton pump is present on intracellular vacuoles induced by Helicobacter pylori

1996 • 47 citations

A Single Cell Analysis of Apoptosis: Ordering the Apoptotic Phenotype

2000 • 47 citations

Mutational Analysis of the Helicobacter pylori Vacuolating Toxin Amino Terminus: Identification of Amino Acids Essential for Cellular Vacuolation

2000 • 45 citations

In Vivo Disruption of the Fas Pathway Abrogates Gastric Growth Alterations Secondary toHelicobacterInfection

2000 • 45 citations

Chapter 16 The (Holey) study of mitochondria in apoptosis

2001 • 41 citations

Functional complementation reveals the importance of intermolecular monomer interactions for Helicobacter pylori VacA vacuolating activity

2002 • 35 citations

Helicobacter pylori Induces Apoptosis in Barrett's-Derived Esophageal Adenocarcinoma Cells

2003 • 26 citations

Fluorescence Resonance Energy Transfer Microscopy of the Helicobacter pylori Vacuolating Cytotoxin within Mammalian Cells

2002 • 26 citations

p16^Ink4a is Overexpressed in H. pylori‐Associated Gastritis and is Correlated with Increased Epithelial Apoptosis

2003 • 12 citations