Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

1969 • 6,007 citations

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Oxidative Stress in Neurodegenerative Diseases

1996 • 1,336 citations

NMDA-dependent superoxide production and neurotoxicity

1993 • 1,188 citations

Role of Oxidants in Ischemic Brain Damage

1996 • 1,037 citations

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.

1996 • 976 citations

Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis

1995 • 834 citations

Estrogens Attenuate and Corticosterone Exacerbates Excitotoxicity, Oxidative Injury, and Amyloid β‐Peptide Toxicity in Hippocampal Neurons

1996 • 833 citations

A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide

1997 • 779 citations

Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate

1995 • 779 citations

Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death

1995 • 744 citations

Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

1993 • 703 citations

Neurotrophic Factors Attenuate Glutamate‐Induced Accumulation of Peroxides, Elevation of Intracellular Ca²⁺ Concentration, and Neurotoxicity and Increase Antioxidant Enzyme Activities in Hippocampal Neurons

1995 • 616 citations

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models

1995 • 604 citations

Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

1994 • 569 citations

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

1995 • 559 citations

A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture

1996 • 534 citations

Calcium-Mediated Mechanisms in Chemically Induced Cell Death

1992 • 518 citations

Covalent attachment of 4-hydroxynonenal to glyceraldehyde-3-phosphate dehydrogenase. A possible involvement of intra- and intermolecular cross-linking reaction.

1993 • 512 citations

Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain

1993 • 481 citations

Neural apoptosis

1995 • 464 citations

Secreted Forms of β-Amyloid Precursor Protein Protect Hippocampal Neurons against Amyloid β-Peptide-Induced Oxidative Injury

1994 • 445 citations

Free radicals in brain metabolism and pathology

1993 • 443 citations

[1] Glutathione metabolism

1995 • 406 citations

Separation and characterization of the aldehydic products of lipid peroxidation stimulated by carbon tetrachloride or ADP-iron in isolated rat hepatocytes and rat liver microsomal suspensions

1985 • 362 citations

Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity.

1991 • 359 citations

4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes

1997 • 355 citations

Chapter 10 Calcium, Free Radicals, and Excitotoxic Neuronal Death in Primary Cell Culture

1995 • 338 citations

Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

1991 • 337 citations

Signalling mechanisms and oxidative stress in apoptosis

1995 • 306 citations

Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons.

1994 • 291 citations

Oxygen Free Radicals and Brain Dysfunction

1991 • 280 citations

N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells

1995 • 273 citations

Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione

1994 • 268 citations

Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway

1996 • 267 citations

Growth Factors Prevent Mitochondrial Dysfunction, Loss of Calcium Homeostasis, and Cell Injury, but Not ATP Depletion in Hippocampal Neurons Deprived of Glucose

1993 • 265 citations

Michael Addition-Type 4-Hydroxy-2-nonenal Adducts in Modified Low-Density Lipoproteins: Markers for Atherosclerosis

1994 • 248 citations

The Protooncogene bcl‐2 Inhibits Apoptosis in PC12 Cells

1993 • 222 citations

Shift of the Cellular Oxidation‐Reduction Potential in Neural Cells Expressing Bcl‐2

1996 • 221 citations

Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons

1994 • 208 citations

The Intracellular Component of Cellular 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide (MTT) Reduction Is Specifically Inhibited by β‐Amyloid Peptides

1995 • 204 citations

Basic FGF, NGF, and IGFs Protect Hippocampal and Cortical Neurons against Iron-Induced Degeneration

1993 • 199 citations

The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation.

1996 • 190 citations

Role of cardiac glutathione transferase and of the glutathione S-conjugate export system in biotransformation of 4-hydroxynonenal in the heart.

1986 • 187 citations

Neuronal Apoptosis: Current Understanding of Molecular Mechanisms and Potential Role in Ischemic Brain Injury

1995 • 168 citations

3‐Nitropropionic Acid Neurotoxicity Is Attenuated in Copper/Zinc Superoxide Dismutase Transgenic Mice

1995 • 162 citations

Monoclonal Antibodies for Detection of 4-Hydroxynonenal Modified Proteins

1996 • 152 citations

Cell death induced by β-amyloid 1–40 in MES 23.5 hybrid clone: the role of nitric oxide and NMDA-gated channel activation leading to apoptosis

1995 • 137 citations

Differential Induction of Immediate Early Gene Proteins in Cultured Neurons by β‐Amyloid (Aβ): Association of c‐Jun with Aβ‐Induced Apoptosis

1995 • 136 citations

Bcl‐2 Protects Neural Cells from Cyanide/Aglycemia‐Induced Lipid Oxidation, Mitochondrial Injury, and Loss of Viability

1995 • 126 citations

A decrease in intracellular glutathione concentration precedes the onset of apoptosis in murine thymocytes.

1995 • 125 citations

Neuroprotective Action of Cycloheximide Involves Induction of Bcl-2 and Antioxidant Pathways

1997 • 122 citations

Cytotoxicity and metabolism of 4-hydroxy-2-nonenal and 2-nonenal in H2O2-resistant cell lines. Do aldehydic by-products of lipid peroxidation contribute to oxidative stress?

1990 • 116 citations

BCL-2 blocks glutamate toxicity in neural cell lines

1993 • 99 citations

THE USE OF TETRAZOLIUM SALTS TO DETERMINE SITES OF DAMAGE TO THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN IN INTACT CELLS FOLLOWING in vitro: PHOTODYNAMIC THERAPY WITH PHOTOFRIN II

1994 • 97 citations

Metabolism of 4-hydroxynonenal, a cytotoxic lipid peroxidation product, in Ehrlich mouse ascites cells at different proliferation stages.

1994 • 93 citations

Ca2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons

1994 • 92 citations

Lipid Peroxidation in Rat Brain Cortical Slices as Measured by the Thiobarbituric Acid Test

1980 • 90 citations

Prolonged Pretreatment with α-Lipoic Acid Protects Cultured Neurons against Hypoxic, Glutamate-, or Iron-Induced Injury

1995 • 84 citations

Involvement of Ca2+ in the Formation of High-Molecular-Weight DNA Fragments in Thymocyte Apoptosis

1994 • 74 citations

Effects of microtubule stabilization and destabilization on tau immunoreactivity in cultured hippocampal neurons

1992 • 62 citations

Generation of reactive oxygen intermediates after treatment of blasts of acute myeloblastic leukemia with cytosine arabinoside: role of bcl-2.

1996 • 59 citations

Kinetic analysis of glutathione in anchored cells with monochlorobimane

1995 • 54 citations

Identification of metabolic pathways of the lipid peroxidation product 4‐hydroxynonenal by mitochondria isolated from rat kidney cortex

1994 • 52 citations

THE USE OF TETRAZOLIUM SALTS TO DETERMINE SITES OF DAMAGE TO THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN IN INTACT CELLS FOLLOWING in vitro PHOTODYNAMIC THERAPY WITH PHOTOFRIN II

1994 • 48 citations

Calcium Homeostasis and Free Radical Metabolism as Convergence Points in the Pathophysiology of Dementia

1997 • 37 citations

Cytotoxic and genotoxic effects of five in primary cultures of rat and human hepatocytes

1994 • 35 citations

Aurintricarboxylic acid is an inhibitor of mu- and m-calpain.

1995 • 35 citations

Expression ofBCL-2Inhibits Cellular Radical Generation

1996 • 27 citations

Parkinson's disease. The apoptosis hypothesis.

1996 • 22 citations

Excitotoxicity at Both NMDA and Non‐NMDA Glutamate Receptors Is Antagonized by Aurintricarboxylic Acid: Evidence for Differing Mechanisms of Action

1995 • 17 citations

The impairment of mitochondrial membrane potential and mass in proliferating lymphocytes from vitamin E deficient animals is recovered by glutathione.

1995 • 9 citations

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