Nicotine Inactivation of the Proapoptotic Function of Bax through Phosphorylation

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Tobacco Smoke Carcinogens and Lung Cancer

1999 • 1,927 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

Preferential Formation of Benzo[ a ]pyrene Adducts at Lung Cancer Mutational Hotspots in P53

1996 • 1,636 citations

Cytosol-to-membrane redistribution of Bax and Bcl-X_Lduring apoptosis

1997 • 1,117 citations

Structure of Bax

2000 • 1,066 citations

Pharmacologic Aspects of Cigarette Smoking and Nicotine Addiction

1988 • 982 citations

Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade

1995 • 960 citations

A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX

1990 • 923 citations

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

2001 • 815 citations

Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis

2001 • 781 citations

Conformation of the Bax C-terminus regulates subcellular location and cell death

1999 • 723 citations

In vivo ubiquitination and proteasome-mediated degradation of p53(1).

1996 • 643 citations

Regulated Targeting of BAX to Mitochondria

1998 • 617 citations

Bcl-2 Phosphorylation Required for Anti-apoptosis Function

1997 • 540 citations

Tumor-cell resistance to death receptor–induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax

2002 • 515 citations

Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells

2003 • 506 citations

Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells

2003 • 488 citations

Bax and Bak Coalesce into Novel Mitochondria-Associated Clusters during Apoptosis

2001 • 466 citations

Bax degradation by the ubiquitin/proteasome-dependent pathway: Involvement in tumor survival and progression

2000 • 439 citations

×Phosphorylation of Bax Ser184 by Akt Regulates Its Activity and Apoptosis in Neutrophils

2004 • 382 citations

The Phosphatidylinositol 3-Kinase (PI3K)-Akt Pathway Suppresses Bax Translocation to Mitochondria

2002 • 369 citations

Bcl-2 Prevents Bax Oligomerization in the Mitochondrial Outer Membrane

2001 • 320 citations

Novel Role for JNK as a Stress-activated Bcl2 Kinase

2001 • 290 citations

Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines.

1990 • 288 citations

New members of the Bcl-2 family and their protein partners

1996 • 248 citations

Mutagenesis of the BH3 Domain of BAX Identifies Residues Critical for Dimerization and Killing

1998 • 206 citations

Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells

1998 • 203 citations

Peg3/Pw1 promotes p53-mediated apoptosis by inducing Bax translocation from cytosol to mitochondria

2000 • 191 citations

Mechanisms of smoking-related lung and pancreatic adenocarcinoma development

2002 • 185 citations

Prohibitin, an antiproliferative protein, is localized to mitochondria

1995 • 184 citations

Regulating protein degradation by ubiquitination

1997 • 169 citations

Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer

2003 • 159 citations

A Functional Role for Nicotine in Bcl2 Phosphorylation and Suppression of Apoptosis

2003 • 153 citations

Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer

2003 • 138 citations

Mitochondria, calcium and pro-apoptotic proteins as mediators in cell death signaling

2003 • 136 citations

Nicotine Induces Multi-site Phosphorylation of Bad in Association with Suppression of Apoptosis

2004 • 133 citations

Cleavage of Bax to p18 Bax accelerates stress-induced apoptosis, and a cathepsin-like protease may rapidly degrade p18 Bax

2003 • 116 citations

β-adrenergic mitogenic signal transduction in peripheral lung adenocarcinoma: Implications for individuals with preexisting chronic lung disease

1995 • 74 citations

Is it more important to quit smoking than which chemotherapy is used?

2003 • 54 citations

Apoptosis via the B cell antigen receptor requires Bax translocation and involves mitochondrial depolarization, cytochrome C release, and caspase‐9 activation

2004 • 42 citations

A model of BAX gene delivery to human lung cancer.

2002 • 8 citations

Blockers of adrenergic neurons and receptors, tumor progression and effects of rotational stress in mice.

1996 • 8 citations