Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy

Cell Death

2004 • 4,599 citations

Development by Self-Digestion

2004 • 3,562 citations

Induction of autophagy and inhibition of tumorigenesis by beclin 1

1999 • 3,194 citations

The role of autophagy during the early neonatal starvation period

2004 • 2,753 citations

In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker

2003 • 2,218 citations

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

2003 • 2,136 citations

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

2003 • 2,041 citations

Autophagy in cell death: an innocent convict?

2005 • 1,655 citations

Inhibition of Macroautophagy Triggers Apoptosis

2005 • 1,581 citations

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

2004 • 1,322 citations

Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells

2001 • 1,310 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast

1998 • 1,271 citations

Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans

2003 • 1,214 citations

Regulation of an ATG7 - beclin 1 Program of Autophagic Cell Death by Caspase-8

2004 • 1,204 citations

Protection against Fatal Sindbis Virus Encephalitis by Beclin, a Novel Bcl-2-Interacting Protein

1998 • 1,091 citations

Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells

2000 • 1,087 citations

Bcl-2 family proteins

1998 • 1,055 citations

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

1995 • 832 citations

Autophagy Regulates Programmed Cell Death during the Plant Innate Immune Response

2005 • 814 citations

Beclin–phosphatidylinositol 3‐kinase complex functions at the trans ‐Golgi network

2001 • 786 citations

Autophagy in metazoans: cell survival in the land of plenty

2005 • 752 citations

Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway

2001 • 705 citations

Apoptosis, autophagy, and more

2004 • 678 citations

Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation

2001 • 531 citations

Essential Roles of Atg5 and FADD in Autophagic Cell Death

2005 • 522 citations

Recombination-mediated PCR-directed plasmid construction in vivo in yeast

1997 • 515 citations

Ceramide-mediated Macroautophagy Involves Inhibition of Protein Kinase B and Up-regulation of Beclin 1

2004 • 422 citations

The Evolutionarily Conserved Domain of Beclin 1 is Required for Vps34 Binding, Autophagy, and Tumor Suppressor Function

2005 • 406 citations

Endosome to Golgi Retrieval of the Vacuolar Protein Sorting Receptor, Vps10p, Requires the Function of the VPS29, VPS30, and VPS35 Gene Products

1997 • 393 citations

Growth retardation and tumour inhibition by BRCA1

1996 • 360 citations

Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.

1996 • 335 citations

Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis

2004 • 274 citations

Amino Acids Interfere with the ERK1/2-dependent Control of Macroautophagy by Controlling the Activation of Raf-1 in Human Colon Cancer HT-29 Cells

2003 • 269 citations

Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function.

2001 • 263 citations

Role of Rab5 in the Recruitment of hVps34/p150 to the Early Endosome

2002 • 200 citations

Transgenic Expression of Bcl-2 Modulates Energy Metabolism, Prevents Cytosolic Acidification During Ischemia, and Reduces Ischemia/Reperfusion Injury

2004 • 191 citations

Bcl-2 phosphorylation and apoptosis activated by damaged microtubules require mTOR and are regulated by Akt

2004 • 135 citations

Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells

2003 • 117 citations

Cellular Distribution of Bcl-2 Family Proteins

2003 • 60 citations

Analyses of Gα-Interacting Protein and Activator of G-Protein-Signaling-3 Functions in Macroautophagy

2004 • 54 citations

Interleukin-3 Induces the Phosphorylation of a Distinct Fraction of Bcl-2

1999 • 51 citations