On the effects of paraquat on isolated mitochondria. Evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex

1992 • 737 citations

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1994 • 561 citations

Superoxide- and singlet oxygen-catalyzed lipid peroxidation as a possible mechanism for paraquat (methyl viologen) toxicity

1974 • 540 citations

The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents

1994 • 527 citations

Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations.

1992 • 449 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.

1992 • 443 citations

Physiological effectors modify voltage sensing by the cyclosporin A-sensitive permeability transition pore of mitochondria.

1993 • 315 citations

Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition

1993 • 294 citations

Evidence for energy-dependent accumulation of paraquat into rat lung

1974 • 294 citations

Liver Necrosis and Lipid Peroxidation in the Rat as the Result of Paraquat and Diquat Administration

1980 • 284 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. II. The minimal requirements for pore induction underscore a key role for transmembrane electrical potential, matrix pH, and matrix Ca2+.

1993 • 225 citations

Mitochondrial and glycolytic dysfunction in lethal injury to hepatocytes by t-butylhydroperoxide: protection by fructose, cyclosporin A and trifluoperazine.

1993 • 213 citations

Regulation of the permeability transition pore, a voltage-dependent mitochondrial channel inhibited by cyclosporin A

1994 • 208 citations

The action of paraquat and diquat on the respiration of liver cell fractions

1968 • 197 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. I. Evidence for two separate Me2+ binding sites with opposing effects on the pore open probability.

1993 • 191 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by matrix pH. Evidence that the pore open-closed probability is regulated by reversible histidine protonation

1993 • 181 citations

NADPH: ferredoxin oxidoreductase acts as a paraquatdiaphorase and is a member of the soxRS regulon.

1994 • 142 citations

Nitric oxide as a mediator of oxidant lung injury due to paraquat.

1994 • 115 citations

Intrinsic uncoupling of mitochondrial proton pumps. 1. Nonohmic conductance cannot account for the nonlinear dependence of static head respiration on .DELTA.~.mu.H

1986 • 114 citations

In vivo oxidation of reduced nicotinamide-adenine dinucleotide phosphate by paraquat and diquat in rat lung

1977 • 99 citations

Mechanism of cytotoxicity of paraquat

1993 • 94 citations

Cyclosporin a protects hepatocytes against prooxidant-induced cell killing

1992 • 94 citations

Lipid peroxidation and paraquat toxicity

1979 • 90 citations

On the mechanism of paraquat action on microsomal oxygen reduction and its relation to lipid peroxidation

1979 • 80 citations

Paraquat and NADPH-dependent lipid peroxidation in lung microsomes.

1981 • 77 citations

Mechanism of cytotoxicity of paraquat

1993 • 52 citations

Protection by cyclosporin A of cultured hepatocytes from the toxic consequences of the loss of mitochondrial energization produced by 1-methyl-4-phenylpyridinium

1992 • 41 citations

Paraquat damage of rat liver mitochondria by superoxide production depends on extramitochondrial NADH

1992 • 41 citations

Mitochondrial injury of pulmonary alveolar epithelial cells in acute paraquat intoxication

1985 • 40 citations

Mitochondrial Breakage Induced by the Herbicide Paraquat in Cultured Human Lung Cells

1992 • 33 citations

Effects of Paraquat on the Mitochondrial Structure and Ca-ATPase Activity in Rat Hepatocytes

1985 • 15 citations

Bipyridylium herbicide toxicity in vitro: Comparative study of the cytotoxicity of paraquat and diquat toward the pulmonary alveolar macrophage

1986 • 12 citations

Paraquat toxicity in vitro. I. Pulmonary alveolar macrophages

1985 • 12 citations