Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Mitochondrial control of cell death

2000 • 3,098 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

2001 • 1,327 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

1997 • 1,020 citations

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

1999 • 887 citations

Role of poly(ADP-ribose) synthetase in inflammation and ischaemia–reperfusion

1998 • 687 citations

Opening of the Mitochondrial Permeability Transition Pore Causes Depletion of Mitochondrial and Cytosolic NAD+and Is a Causative Event in the Death of Myocytes in Postischemic Reperfusion of the Heart

2001 • 658 citations

Ischemic Brain Injury is Mediated by the Activation of Poly(ADP-Ribose)Polymerase

1997 • 624 citations

PARP is important for genomic stability but dispensable in apoptosis

1997 • 556 citations

Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?

2000 • 527 citations

The Mitochondrial Permeability Transition, Release of Cytochrome c and Cell Death

2001 • 454 citations

TNF-induced signaling in apoptosis.

1999 • 445 citations

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

1999 • 372 citations

Molecular and biochemical features of poly (ADP-ribose) metabolism

1993 • 300 citations

Oxidative Stress Inhibits Apoptosis in Human Lymphoma Cells

1999 • 281 citations

Failure of Poly(ADP-Ribose) Polymerase Cleavage by Caspases Leads to Induction of Necrosis and Enhanced Apoptosis

1999 • 228 citations

Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death.

1998 • 218 citations

NMDA But Not Non-NMDA Excitotoxicity is Mediated by Poly(ADP-Ribose) Polymerase

2000 • 216 citations

Apoptosis Control in Syncytia Induced by the HIV Type 1–Envelope Glycoprotein Complex

2000 • 213 citations

Structure and function of poly(ADP-ribose) polymerase

1994 • 206 citations

Poly(ADP-Ribose) Synthetase Activation Mediates Mitochondrial Injury During Oxidant-Induced Cell Death

1998 • 204 citations

Myocardial Postischemic Injury Is Reduced by PolyADPribose Polymerase-1 Gene Disruption

2000 • 153 citations

Roles of poly(ADP-ribosyl)ation and PARP in apoptosis, DNA repair, genomic stability and functions of p53 and E2F-1

2000 • 125 citations

Poly(ADP-Ribose) Polymerase Inhibition in Oxidant-Stressed Endothelial Cells Prevents Oncosis and Permits Caspase Activation and Apoptosis

1999 • 75 citations

Implication of Poly(ADP‐Ribose) Polymerase (PARP) in Neurodegeneration and Brain Energy Metabolism: Decreases in Mouse Brain NAD⁺ and ATP Caused by MPTP Are Prevented by the PARP Inhibitor Benzamide

1999 • 69 citations