Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Staphylococcus aureusInfections

1998 • 5,749 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 2,450 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 1,969 citations

The Staphylococcal Enterotoxins and Their Relatives

1990 • 1,914 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients

2002 • 1,488 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

New Vector for Efficient Allelic Replacement in Naturally Nontransformable, Low-GC-Content, Gram-Positive Bacteria

2004 • 895 citations

Untitled

1996 • 780 citations

The staphylococci in human disease

1996 • 635 citations

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

2000 • 619 citations

Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte

2000 • 524 citations

Prevention of lymphocyte cell death in sepsis improves survival in mice

1999 • 444 citations

Pathology of infectious diseases

1997 • 377 citations

The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release

2000 • 354 citations

Intracellular Staphylococcus aureus Escapes the Endosome and Induces Apoptosis in Epithelial Cells

1998 • 342 citations

Panton-Valentine leucocidin and gamma-hemolysin from Staphylococcus aureus ATCC 49775 are encoded by distinct genetic loci and have different biological activities

1995 • 303 citations

Hepatic failure and liver cell damage in acute Wilson's disease involve CD95 (APO-1 /Fas) Mediated apoptosis

1998 • 279 citations

The Staphylococcus aureus “superbug”

2004 • 276 citations

Neuroprotection by a caspase inhibitor in acute bacterial meningitis

1999 • 265 citations

Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis.

1998 • 253 citations

CD95/CD95 Ligand Interactions on Epithelial Cells in Host Defense to Pseudomonas aeruginosa

2000 • 251 citations

The Staphylococcus aureus “superbug”

2004 • 248 citations

Elucidation of Molecular Events Leading to Neutrophil Apoptosis following Phagocytosis

2003 • 236 citations

Natural population dynamics and expansion of pathogenic clones of Staphylococcus aureus

2004 • 235 citations

Internalization ofStaphylococcus aureusby Endothelial Cells Induces Apoptosis

1998 • 234 citations

Novel path to apoptosis: small transmembrane pores created by staphylococcal alpha-toxin in T lymphocytes evoke internucleosomal DNA degradation

1994 • 234 citations

Involvement of TNF-Related Apoptosis-Inducing Ligand in Human CD4+ T Cell-Mediated Cytotoxicity

1999 • 230 citations

Natural population dynamics and expansion of pathogenic clones of Staphylococcus aureus

2004 • 214 citations

Differential Regulation and ATP Requirement for Caspase-8 and Caspase-3 Activation during CD95- and Anticancer Drug–induced Apoptosis

1998 • 213 citations

Staphylococcus aureus RN6390 Replicates and Induces Apoptosis in a Pulmonary Epithelial Cell Line

2000 • 200 citations

Diablo Promotes Apoptosis by Removing Miha/Xiap from Processed Caspase 9

2001 • 198 citations

Neutralization ofStaphylococcus aureusPanton Valentine Leukocidin by Intravenous Immunoglobulin In Vitro

2004 • 195 citations

α-Toxin is a mediator of Staphylococcus aureus–induced cell death and activates caspases via the intrinsic death pathway independently of death receptor signaling

2001 • 183 citations

Effects Of Staphylococcus Aureus Leukocidins On Inflammatory Mediator Release From Human Granulocytes

1995 • 156 citations

Staphylococcus aureus Agr and Sar Global Regulators Influence Internalization and Induction of Apoptosis

1998 • 156 citations

The structure of a Staphylococcus aureus leucocidin component (LukF-PV) reveals the fold of the water-soluble species of a family of transmembrane pore-forming toxins

1999 • 149 citations

Conformational Changes in the Mitochondrial Channel Protein, VDAC, and Their Functional Implications

1998 • 143 citations

Targeting of the pro-apoptotic VDAC-like porin (PorB) of Neisseria gonorrhoeae to mitochondria of infected cells

2000 • 133 citations

Modulation of Neisseria Porin (PorB) by Cytosolic ATP/GTP of Target Cells: Parallels between Pathogen Accommodation and Mitochondrial Endosymbiosis

1996 • 133 citations

Pore formation by a two-component leukocidin from Staphyloccocus aureus within the membrane of human polymorphonuclear leukocytes

1993 • 123 citations

Fractional Statistics: Early Work

1990 • 122 citations

Interaction of the two components of leukocidin from Staphylococcus aureus with human polymorphonuclear leukocyte membranes: sequential binding and subsequent activation

1994 • 122 citations

Subunit composition of a bicomponent toxin: Staphylococcal leukocidin forms an octameric transmembrane pore

2002 • 121 citations

Staphylococcus aureusα-toxin induces apoptosis in endothelial cells

2000 • 120 citations

Apoptosis Induced byStaphylococcus aureusin Epithelial Cells Utilizes a Mechanism Involving Caspases 8 and 3

2000 • 107 citations

The Apoptosome Pathway to Caspase Activation in Primary Human Neutrophils Exhibits Dramatically Reduced Requirements for Cytochrome c

2003 • 95 citations

Fractionation of a leucocidin from Staphylococcus aureus

1959 • 93 citations

From the Centers for Disease Control and Prevention. Four pediatric deaths from community-acquired methicillin-resistant Staphylococcus aureus--Minnesota and North Dakota, 1997-1999.

1999 • 92 citations

Intracellular Staphylococcus aureus induces apoptosis in mouse osteoblasts

2000 • 91 citations

Staphylococcal leucocidins.

1957 • 88 citations

Minimal BH3 Peptides Promote Cell Death by Antagonizing Anti-apoptotic Proteins

2003 • 88 citations

Flow Cytometric Determination of Panton-Valentine Leucocidin S Component Binding

2001 • 87 citations

Cloning and nucleotide sequence of a chromosomally encoded tetracycline resistance determinant, tetA(M), from a pathogenic, methicillin-resistant strain of Staphylococcus aureus

1990 • 71 citations

Apoptosis of human keratinocytes after bacterial invasion

2000 • 66 citations

Fas (CD95)-Fas Ligand Interactions Are Responsible for Monocyte Apoptosis Occurring as a Result of Phagocytosis and Killing ofStaphylococcus aureus

2001 • 63 citations

Application of flow cytometry in toxinology: Pathophysiology of human polymorphonuclear leukocytes damaged by a pore‐forming toxin from Staphylococcus aureus

1995 • 47 citations

Leukotriene B4 generation and DNA fragmentation induced by leukocidin from Staphylococcus aureus: protective role of granulocyte-macrophage colony-stimulating factor (GM-CSF) and G-CSF for human neutrophils

1994 • 46 citations

Discoupling the Ca²⁺‐activation from the pore‐forming function of the bi‐component Panton‐Valentine leucocidin in human PMNs

1999 • 41 citations

Changes in binding of staphylococcal leukocidin to HL-60 cells during differentiation induced by dimethyl sulfoxide

1988 • 12 citations

Crystallization and preliminary crystallographic data of a leucotoxin S component fromStaphylococcus aureus

2004 • 10 citations

Effects of leukocidin from fusobacterium necrophorum on bovine peripheral leukocytes in vitro

1988 • 2 citations