Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma

Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function

2005 • 1,751 citations

BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

2001 • 1,672 citations

Structure of Bcl-x _L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

1997 • 1,429 citations

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

2003 • 1,298 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

2000 • 1,245 citations

BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death

2000 • 1,033 citations

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c

2000 • 994 citations

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

2001 • 815 citations

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

2002 • 699 citations

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1997 • 648 citations

Bcl-2-family proteins: the role of the BH3 domain in apoptosis

1998 • 641 citations

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

2003 • 551 citations

Bim is a suppressor of Myc-induced mouse B cell leukemia

2004 • 485 citations

bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

1997 • 371 citations

Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis

2005 • 325 citations

Bad -deficient mice develop diffuse large B cell lymphoma

2003 • 268 citations

Analysis of the p53/BAX Pathway in Colorectal Cancer: Low BAX Is a Negative Prognostic Factor in Patients With Resected Liver Metastases

1999 • 174 citations

Proapoptotic BID is required for myeloid homeostasis and tumor suppression

2003 • 170 citations

Guardians of cell death: the Bcl-2 family proteins

2003 • 158 citations

Dynamic Expression Profile of p21^WAF1/CIP1 and Ki-67 Predicts Survival in Rectal Carcinoma Treated With Preoperative Radiochemotherapy

2003 • 133 citations

Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53

2002 • 123 citations

Proapoptotic BH3-Only Bcl-2 Family Member Bik/Blk/Nbk Is Expressed in Hemopoietic and Endothelial Cells but Is Redundant for Their Programmed Death

2004 • 116 citations

Analysis of p53/BAX/p16^ink4a/CDKN2 in Esophageal Squamous Cell Carcinoma: High BAX and p16^ink4a/CDKN2 Identifies Patients With Good Prognosis

2001 • 114 citations

Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway

2003 • 111 citations

p53 Pathway in Renal Cell Carcinoma Is Repressed by a Dominant Mechanism

2004 • 106 citations

Nonredundant Role of Bax and Bak in Bid-Mediated Apoptosis

2003 • 103 citations

Type I and type II reactions in TRAIL-induced apoptosis – results from dose–response studies

2004 • 89 citations

Multicolor-FICTION

2002 • 81 citations

Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL and 5-FU through the mitochondrial apoptosis pathway

2004 • 80 citations

The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosis

2004 • 78 citations

Induction of apoptosis and G2/M arrest by infection with replication-deficient adenovirus at high multiplicity of infection

1999 • 73 citations

Induction of p21CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells

2005 • 73 citations

The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1-overexpressing breast cancer cell lines

2002 • 61 citations

Microarray Analysis of p53 Target Gene Expression Patterns in the Spleen and Thymus in Response to Ionizing Radiation

2003 • 59 citations

Expression of the Death Gene Bik/Nbk Promotes Sensitivity to Drug-Induced Apoptosis in Corticosteroid-Resistant T-Cell Lymphoma and Prevents Tumor Growth in Severe Combined Immunodeficient Mice

1999 • 54 citations

Caspase-independent induction of apoptosis in human melanoma cells by the proapoptotic Bcl-2-related protein Nbk / Bik

2005 • 46 citations

Downregulation of genes involved in DNA repair and differential expression of transcription regulators and phosphatases precede IgM-induced apoptosis in the Burkitt's lymphoma cell line BL60-2

2003 • 5 citations