Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium Signals

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Calcium signaling

1995 • 1,905 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Microdomains with High Ca ²⁺ Close to IP ₃ -Sensitive Channels that Are Sensed by Neighboring Mitochondria

1993 • 1,167 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

Decoding of cytosolic calcium oscillations in the mitochondria

1995 • 1,090 citations

Inositol Trisphosphate and Calcium Signaling

1995 • 1,036 citations

The biochemistry of programmed cell death

1995 • 997 citations

Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion

1995 • 830 citations

Mitochondrial Participation in the Intracellular Ca2+ Network

1997 • 556 citations

Mitochondrial calcium transport

1982 • 486 citations

Spatial and temporal aspects of cellular calcium signaling

1996 • 480 citations

The permeability transition pore as a mitochondrial calcium release channel: A critical appraisal

1996 • 466 citations

Interactions of Cyclophilin with the Mitochondrial Inner Membrane and Regulation of the Permeability Transition Pore, a Cyclosporin A-sensitive Channel

1996 • 460 citations

Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes

1995 • 425 citations

Mitochondrial ADP/ATP Carrier Can Be Reversibly Converted into a Large Channel by Ca²⁺

1996 • 421 citations

Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide

1995 • 384 citations

Dominant Role of Mitochondria in Clearance of Large Ca2+ Loads from Rat Adrenal Chromaffin Cells

1996 • 352 citations

A Reevaluation of the Role of Mitochondria in Neuronal Ca²⁺ Homeostasis

1996 • 347 citations

Ca2+-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons

1992 • 336 citations

Mitochondrial Calcium Uptake from Physiological-type Pulses of Calcium

1995 • 299 citations

Inhibition of Fura-2 sequestration and secretion with organic anion transport blockers

1990 • 298 citations

Ca2+ As a Second Messenger within Mitochondria of the Heart and other Tissues

1990 • 297 citations

The osmotic behavior and permeability to non-electrolytes of mitochondria

1955 • 293 citations

Transport of calcium by mitochondria

1994 • 276 citations

An FCCP-sensitive Ca2+ store in bullfrog sympathetic neurons and its participation in stimulus-evoked changes in [Ca2+]i

1994 • 262 citations

Swelling and contraction of the mitochondrial matrix. I. A structural interpretation of the relationship between light scattering and matrix volume.

1985 • 237 citations

Dynamic pacing of cell metabolism by intracellular Ca2+ transients.

1994 • 185 citations

A heart mitochondrial Ca2+-dependent pore of possible relevance to re-perfusion-induced injury. Evidence that ADP facilitates pore interconversion between the closed and open states

1990 • 168 citations

Calcium signalling in T cells stimulated by a cyclophilin B-binding protein

1994 • 162 citations

Selectivity of cation chelation to tetracyclines: Evidence for special conformation of calcium chelate

1971 • 162 citations

Mitochondrial calcium spiking: A transduction mechanism based on calcium‐induced permeability transition involved in cell calcium signalling

1994 • 149 citations

Mitochondria Support Inositol 1,4,5-Trisphosphate-mediated Ca2+ Waves in Cultured Oligodendrocytes

1996 • 147 citations

Determination of the matrix free Ca2+ concentration and kinetics of Ca2+ efflux in liver and heart mitochondria.

1982 • 144 citations

Selective Localization of Tetracycline in Mitochondria of Living Cells

1961 • 143 citations

Physiological cytosolic Ca2+ transients evoke concurrent mitochondrial depolarizations.

1994 • 139 citations

Evidence for mitochondrial localization of the hormone-responsive pool of Ca2+ in isolated hepatocytes.

1979 • 128 citations

Use of chlorotetracycline fluorescence to demonstrate Ca2+-induced release of Ca2+ from the sarcoplasmic reticulum of skinned cardiac cells

1979 • 127 citations

The migration of divalent cations in mitochondria visualized by a fluorescent chelate probe

1972 • 126 citations

Extracellular ATP activates polyphosphoinositide breakdown and Ca2+ mobilization in Ehrlich ascites tumor cells

1986 • 125 citations

Chaotropic Agents and Increased Matrix Volume Enhance Binding of Mitochondrial Cyclophilin to the Inner Mitochondrial Membrane and Sensitize the Mitochondrial Permeability Transition to [Ca²⁺]

1996 • 105 citations

Cyclosporin A inhibits Ca2+/calmodulin-dependent protein phosphatase and secretion in pancreatic acinar cells.

1994 • 84 citations

Luminal communication between intracellular calcium stores modulated by GTP and the cytoskeleton.

1994 • 84 citations

Calcium ion-dependent signalling and mitochondrial dysfunction: mitochondrial calcium uptake during hormonal stimulation in intact liver cells and its implication for the mitochondrial permeability transition

1995 • 84 citations

EGTA inhibits reverse uniport-dependent Ca2+ release from uncoupled mitochondria. Possible regulation of the Ca2+ uniporter by a Ca2+ binding site on the cytoplasmic side of the inner membrane.

1988 • 81 citations

Inositol 1,4,5-trisphosphate and intracellular Ca2+ homeostasis in clonal pituitary cells (GH3). Translocation of Ca2+ into mitochondria from a functionally discrete portion of the nonmitochondrial store.

1986 • 80 citations

Glucagon effects on the membrane potential and calcium uptake rate of rat liver mitochondria.

1984 • 74 citations

Microtubule‐active drugs suppress the closure of the permeability transition pore in tumour mitochondria

1996 • 71 citations

Permeability to water, dimension of surface, and structural changes during swelling in rat liver mitochondria

1972 • 68 citations

Pathway for uncoupler-induced calcium efflux in rat liver mitochondria: inhibition by Ruthenium Red

1984 • 60 citations

Inositol trisphosphate receptor mediated spatiotemporal calcium signalling

1995 • 59 citations

Studies of the Energy-dependent Uptake of Divalent Metal Ions by Beef Heart Mitochondria

1974 • 55 citations

Kinetic Analysis of the Mitochondrial Permeability Transition

1996 • 43 citations

Ion and pH gradients across the transport membrane of mitochondria following Mn++ uptake in the presence of acetate

1973 • 42 citations

The Ca2+-induced permeability transition pore is involved in Ca2+-induced mitochondrial oscillations

1994 • 40 citations

Confocal laser microscopical images of calcium distribution and intracellular organelles in the outer hair cell isolated from the guinea pig cochlea

1993 • 37 citations

Studies of mitochondrial calcium movements using chlorotetracycline

1976 • 36 citations

Mobilization of intracellular calcium by extracellular ATP and by calcium ionophores in the Ehrlich ascites-tumour cell

1988 • 35 citations

Is bupivacaine a decoupler, a protonophore or a proton‐leak‐inducer?

1992 • 32 citations

Transient induction of the mitochondrial permeability transition by uncoupler plus a Ca2+-specific chelator

1991 • 19 citations

A calcium-rich intraspindle membrane system in spermatocytes of wolf spiders

1984 • 17 citations

Oscillating dissipative structures in mitochondrial suspensions

1986 • 14 citations

Strontium excitability of the inner mitochondrial membrane: regenerative strontium-induced strontium release.

1995 • 14 citations

Effect of Spermine on Mitochondrial Matrix Calcium in Relation to Its Enhancement of Mitochondrial Calcium Uptake

1993 • 13 citations

Chlortetracycline and the transmembrane potential of the inner membrane of plant mitochondria

1986 • 13 citations

Ca2+ transport in mitochondria of the ciliate protozoan Tetrahymena pyriformis

1984 • 6 citations

Tracking of proton flow during transition from anaerobiosis to steady state

1991 • 6 citations

Confocal laser-scanning microscopical image of the distribution of intracellular organelles in cochlear outer hair cells.

1993 • 4 citations