A Role of the Mitochondrial Apoptosis-Inducing Factor in Granulysin-Induced Apoptosis

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

Mitochondrial control of cell death

2000 • 3,098 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

1988 • 3,038 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

2000 • 1,150 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin

1998 • 1,019 citations

Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors

1998 • 984 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 826 citations

Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis

2000 • 778 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 751 citations

Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium Signals

1997 • 739 citations

Two Distinct Pathways Leading to Nuclear Apoptosis

2000 • 737 citations

The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

1998 • 700 citations

Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis.

1995 • 598 citations

Differential Modulation of Apoptosis Sensitivity in CD95 Type I and Type II Cells

1999 • 595 citations

Target Protease Specificity of the Viral Serpin CrmA

1997 • 517 citations

Caspase-9 Can Be Activated without Proteolytic Processing

1999 • 498 citations

Caspase Independent/Dependent Regulation of K+, Cell Shrinkage, and Mitochondrial Membrane Potential during Lymphocyte Apoptosis

1999 • 297 citations

Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins.

1997 • 259 citations

Granzyme A Loading Induces Rapid Cytolysis and a Novel Form of DNA Damage Independently of Caspase Activation

1999 • 238 citations

Target Cell Lysis by CTL Granule Exocytosis Is Independent of ICE/Ced-3 Family Proteases

1997 • 237 citations

T cell receptor‐induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A

1994 • 206 citations

Sphingomyelin Hydrolysis to Ceramide during the Execution Phase of Apoptosis Results from Phospholipid Scrambling and Alters Cell-Surface Morphology

2000 • 200 citations

Ceramide in apoptosis—does it really matter?

1998 • 189 citations

Granzyme A Initiates an Alternative Pathway for Granule-Mediated Apoptosis

1999 • 163 citations

Induction of apoptotic DNA fragmentation and cell death by natural ceramide

1995 • 158 citations

A Distinct Pathway of Cell-Mediated Apoptosis Initiated by Granulysin

2001 • 151 citations

Cleavage of CPP32 by Granzyme B Represents a Critical Role for Granzyme B in the Induction of Target Cell DNA Fragmentation

1996 • 148 citations

Granulysin-Induced Apoptosis. I. Involvement of at Least Two Distinct Pathways

1998 • 133 citations

Doxorubicin Treatment Activates a Z-VAD-Sensitive Caspase, Which Causes ΔΨm Loss, Caspase-9 Activity, and Apoptosis in Jurkat Cells

2000 • 125 citations

Characterization of Calcium Release-activated Apoptosis of LNCaP Prostate Cancer Cells

2000 • 124 citations

Bactericidal and Tumoricidal Activities of Synthetic Peptides Derived from Granulysin

2000 • 120 citations

The isolation and sequence of a novel gene from a human functional T cell line.

1987 • 120 citations

CD95/Fas-induced Ceramide Formation Proceeds with Slow Kinetics and Is Not Blocked by Caspase-3/CPP32 Inhibition

1997 • 115 citations

Plasma membrane potential in thymocyte apoptosis.

1999 • 112 citations

Plasma Membrane Potential in Thymocyte Apoptosis

1999 • 97 citations

CPP32 inhibition prevents Fas‐induced ceramide generation and apoptosis in human cells

1996 • 82 citations

Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl‐2, but not by CrmA

1997 • 70 citations

Lipid membrane binding of NK‐lysin

1998 • 59 citations

Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signalling pathway

1998 • 55 citations

Apoptosis : a practical approach

1999 • 54 citations

Resistance to apoptosis correlates with a highly proliferative phenotype and loss of Fas and CPP32 (caspase-3) expression in human leukemia cells

1998 • 53 citations

Apoptotic Cell Death and Caspase 3 (CPP32) Activation Induced by Calcium Ionophore at Low Concentrations and their Prevention by Nerve Growth Factor in PC12 Cells

1997 • 48 citations

Fas stimulation induces RB dephosphorylation and proteolysis that is blocked by inhibitors of the ICE protease family

1997 • 47 citations

Fluorescent staining of nuclei and amyloid substance. Two useful properties of

1983 • 45 citations

Inhibition of CPP32-like proteases prevents granzyme B- and Fas-, but not granzyme A-based cytotoxicity exerted by CTL clones.

1997 • 39 citations

Comparative Modeling of Amoebapores and Granulysin Based on the NK-Lysin Structure Structural and Functional Implications

1999 • 38 citations

Genomic structure and alternative splicing of 519, a gene expressed late after T cell activation.

1992 • 30 citations

Stimulation of phosphatidylinositol turnover is a key event for Fas-dependent, activation-induced apoptosis in human T lymphocytes.

1996 • 25 citations

Detection of tumor necrosis factor induced nuclear damage with p-phenylenediamine

1992 • 15 citations

Cell-mediated cytotoxicity and cell death receptors

1999 • 1 citations