Endoplasmic Reticulum Stress-induced Apoptosis

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1999 • 3,119 citations

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

2000 • 2,831 citations

Roles of CHOP/GADD153 in endoplasmic reticulum stress

2003 • 2,663 citations

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1999 • 2,237 citations

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

2001 • 2,226 citations

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

2000 • 2,064 citations

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1998 • 1,972 citations

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

2004 • 1,854 citations

Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State

2001 • 1,840 citations

BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

2001 • 1,672 citations

Organelle-specific initiation of cell death pathways

2001 • 1,454 citations

BAX and BAK Regulation of Endoplasmic Reticulum Ca ²⁺ : A Control Point for Apoptosis

2003 • 1,363 citations

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

2003 • 1,298 citations

PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

2001 • 1,275 citations

Orchestrating the unfolded protein response in health and disease

2002 • 1,163 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death

2000 • 1,033 citations

The glucose-regulated proteins: stress induction and clinical applications

2001 • 1,013 citations

Orchestrating the unfolded protein response in health and disease

2002 • 966 citations

Transcriptional and Translational Control in the Mammalian Unfolded Protein Response

2002 • 909 citations

An Endoplasmic Reticulum Stress-specific Caspase Cascade in Apoptosis

2002 • 875 citations

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

2003 • 862 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 858 citations

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death

2004 • 813 citations

Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex

2004 • 748 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 724 citations

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

2002 • 699 citations

Endoplasmic Reticulum Chaperone Protein GRP78 Protects Cells from Apoptosis Induced by Topoisomerase Inhibitors

2003 • 682 citations

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

2003 • 586 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

2001 • 584 citations

Cell Damage-induced Conformational Changes of the Pro-Apoptotic Protein Bak In Vivo Precede the Onset of Apoptosis

1999 • 485 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

2002 • 480 citations

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

2004 • 416 citations

Expression of bbc3 , a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

2001 • 402 citations

Gene expression during ER stress–induced apoptosis in neurons

2003 • 361 citations

Integral role of Noxa in p53-mediated apoptotic response

2003 • 326 citations

Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2

2000 • 304 citations

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3β

2004 • 246 citations

Adult Apaf-1-Deficient Mice Exhibit Male Infertility

2000 • 202 citations

Cadmium Induces Conformational Modifications of Wild-type p53 and Suppresses p53 Response to DNA Damage in Cultured Cells

1999 • 199 citations

Regulation of the C/EBP-related gene gadd153 by glucose deprivation.

1993 • 190 citations

Translocation of Bim to the Endoplasmic Reticulum (ER) Mediates ER Stress Signaling for Activation of Caspase-12 during ER Stress-induced Apoptosis

2004 • 187 citations

The role of Apaf-1, caspase-9, and bid proteins in etoposide- or paclitaxel-induced mitochondrial events during apoptosis.

2000 • 179 citations

Underglycosylation of ATF6 as a Novel Sensing Mechanism for Activation of the Unfolded Protein Response

2004 • 175 citations

BOK and NOXA Are Essential Mediators of p53-dependent Apoptosis

2004 • 152 citations

Molecular Components of a Cell Death Pathway Activated by Endoplasmic Reticulum Stress

2003 • 152 citations

Regulation of the expression and processing of caspase-12

2003 • 132 citations

Caspase-12: an overview

2003 • 130 citations

p53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation

2003 • 123 citations

Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53

2002 • 123 citations

Coupling of caspase-9 to Apaf1 in response to loss of pRb or cytotoxic drugs is cell-type-specific

2004 • 50 citations