Mitochondrial Mechanisms of Neural Cell Death and Neuroprotective Interventions in Parkinson's Disease

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

2000 • 3,559 citations

BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

2001 • 1,672 citations

Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane

2002 • 1,443 citations

Abnormalities of the electron transport chain in idiopathic parkinson's disease

1989 • 1,067 citations

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c

2000 • 994 citations

Origin and functional consequences of the complex I defect in Parkinson's disease

1996 • 629 citations

Changes in cytokines and neurotrophins in Parkinson’s disease

2000 • 494 citations

Role of Mitochondria in Oxidative Stress and Aging

2002 • 483 citations

In VivoDelivery of a Bcl-xL Fusion Protein Containing the TAT Protein Transduction Domain Protects against Ischemic Brain Injury and Neuronal Apoptosis

2002 • 418 citations

Mitochondrial Production of Superoxide Radical and Hydrogen Peroxide

1977 • 415 citations

Modulation of Mitochondrial Function by Hydrogen Peroxide

2001 • 374 citations

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

2001 • 360 citations

Mitochondrial Participation in Ischemic and Traumatic Neural Cell Death

2000 • 350 citations

Coenzyme Q₁₀ levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects

1997 • 321 citations

Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli

2002 • 312 citations

Abnormal Mitochondrial Morphology in Sporadic Parkinson's and Alzheimer's Disease Cybrid Cell Lines

2000 • 286 citations

Neuronal cell death in nervous system development, disease, and injury (Review)

2001 • 256 citations

Calcium Homeostasis and Reactive Oxygen Species Production in Cells Transformed by Mitochondria from Individuals with Sporadic Alzheimer’s Disease

1997 • 253 citations

Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax

2002 • 225 citations

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride Neurotoxicity Is Attenuated in Mice Overexpressing Bcl-2

1998 • 199 citations

The α-ketoglutarate dehydrogenase complex in neurodegeneration

2000 • 192 citations

Calcium induced release of mitochondrial cytochrome c by different mechanisms selective for brain versus liver

1999 • 190 citations

Respiratory Activity of Isolated Rat Brain Mitochondria followingin vitroExposure to Oxygen Radicals

1983 • 181 citations

Mitochondrial permeability transition in acute neurodegeneration

2002 • 180 citations

Estrogen and Bcl-2: Gene Induction and Effect of Transgene in Experimental Stroke

2001 • 179 citations

Zinc Is a Potent Inhibitor of Thiol Oxidoreductase Activity and Stimulates Reactive Oxygen Species Production by Lipoamide Dehydrogenase

2002 • 169 citations

Neuroprotective and neurorestorative strategies for Parkinson's disease

2002 • 162 citations

Bcl-2 prevents mitochondrial permeability transition and cytochrome c release via maintenance of reduced pyridine nucleotides

2000 • 159 citations

Cyclosporin A-insensitive Permeability Transition in Brain Mitochondria

2003 • 133 citations

BH3 Death Domain Peptide Induces Cell Type-selective Mitochondrial Outer Membrane Permeability

2001 • 132 citations

Upregulation of the Fas Receptor Death-Inducing Signaling Complex after Traumatic Brain Injury in Mice and Humans

2002 • 126 citations

Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins

1998 • 112 citations

Inhibition of Bax-Induced CytochromecRelease from Neural Cell and Brain Mitochondria by Dibucaine and Propranolol

2003 • 78 citations

Fas and Fas‐L expression in Huntington's disease and Parkinson's disease

2000 • 60 citations

Effect of Bcl-XL overexpression on reactive oxygen species, intracellular calcium, and mitochondrial membrane potential following injury in astrocytes

2002 • 52 citations