The E2F-1 Transcription Factor Promotes Caspase-8 and Bid Expression, and Enhances Fas Signaling in T Cells

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

Sibling rivalry in the E2F family

2002 • 1,158 citations

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1999 • 999 citations

Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1

1996 • 704 citations

Role for the p53 homologue p73 in E2F-1-induced apoptosis

2000 • 700 citations

Activation‐induced cell death in T cells

2003 • 613 citations

The E2F1–3 transcription factors are essential for cellular proliferation

2001 • 595 citations

Activated T Cell Death In Vivo Mediated by Proapoptotic Bcl-2 Family Member Bim

2002 • 564 citations

Apoptosis in the development and maintenance of the immune system

2003 • 524 citations

Negative selection — clearing out the bad apples from the T-cell repertoire

2003 • 494 citations

Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis.

1993 • 454 citations

A revised picture of the E2F transcriptional network and RB function

2002 • 422 citations

Direct coupling of the cell cycle and cell death machinery by E2F

2002 • 419 citations

Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL−/− mice

2003 • 345 citations

A common E2F-1 and p73 pathway mediates cell death induced by TCR activation

2000 • 326 citations

The genetics of the E2F family of transcription factors: shared functions and unique roles

2002 • 301 citations

E2F4 and E2F5 Play an Essential Role in Pocket Protein–Mediated G1 Control

2000 • 292 citations

Signaling Life and Death in the Thymus: Timing Is Everything

2003 • 255 citations

RETRACTED: The Fas/Fas Ligand Pathway and Bcl-2 Regulate T Cell Responses to Model Self and Foreign Antigens

1998 • 216 citations

E2F and cell cycle control: a double-edged sword

2003 • 199 citations

Attrition of Bystander CD8 T Cells during Virus-Induced T-Cell and Interferon Responses

2001 • 195 citations

E2F4 Is Essential for Normal Erythrocyte Maturation and Neonatal Viability

2000 • 189 citations

Loss of E2F4 Activity Leads to Abnormal Development of Multiple Cellular Lineages

2000 • 173 citations

CD28-dependent Activation of Protein Kinase B/Akt Blocks Fas-mediated Apoptosis by Preventing Death-inducing Signaling Complex Assembly

2002 • 140 citations

Functional Roles of Fas and Bcl-2-Regulated Apoptosis of T Lymphocytes

1998 • 126 citations

TCR Antigen–Induced Cell Death Occurs from a Late G1 Phase Cell Cycle Check Point

1998 • 123 citations

E2F1 and E2F2 Determine Thresholds for Antigen-Induced T-Cell Proliferation and Suppress Tumorigenesis

2001 • 115 citations

Antigen Presentation by Liver Cells Controls Intrahepatic T Cell Trapping, Whereas Bone Marrow-Derived Cells Preferentially Promote Intrahepatic T Cell Apoptosis

2001 • 92 citations

Mutant Mouse Models Reveal the Relative Roles of E2F1 and E2F3 In Vivo

2002 • 89 citations

A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection.

1999 • 87 citations

The Survival of Antigen-Stimulated T Cells Requires NFκB-Mediated Inhibition of p73 Expression

2003 • 86 citations

Normal Thymocyte Negative Selection in TRAIL-deficient Mice

2003 • 72 citations

Fas-Mediated Apoptosis Causes Elimination of Virus-Specific Cytotoxic T Cells in the Virus-Infected Liver

2001 • 69 citations

BID-D59A Is a Potent Inducer of Apoptosis in Primary Embryonic Fibroblasts

2003 • 69 citations

A role for E2F1 in the induction of apoptosis during thymic negative selection.

2000 • 48 citations

Transcriptional Program of Apoptosis Induction following Interleukin 2 Deprivation: Identification of RC3, a Calcium/Calmodulin Binding Protein, as a Novel Proapoptotic Factor

2003 • 37 citations

Different Nature of the Proliferation Defects ofGLD, LPRandMEVC57BL/6 Mouse Lymphoid Cells

1991 • 11 citations