Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis

The versatility and universality of calcium signalling

2000 • 5,407 citations

Regulation of cell death: the calcium–apoptosis link

2003 • 2,826 citations

Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca ²⁺ Responses

1998 • 2,130 citations

The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.

1968 • 1,767 citations

Bell-shaped calcium-response curves of lns(l,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum

1991 • 1,699 citations

Apoptosis Signaling

2000 • 1,290 citations

The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

2000 • 1,046 citations

Calcium as a Coagonist of Inositol 1,4,5-Trisphosphate-Induced Calcium Release

1991 • 843 citations

Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization

2002 • 727 citations

Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury

1999 • 694 citations

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

2002 • 564 citations

Spatio-temporal images of growth-factor-induced activation of Ras and Rap1

2001 • 556 citations

Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria

1999 • 530 citations

[13] Fluorescence resonance energy transfer

1995 • 513 citations

Type I, II, and III Inositol 1,4,5-Trisphosphate Receptors Are Unequally Susceptible to Down-regulation and Are Expressed in Markedly Different Proportions in Different Cell Types

1995 • 418 citations

Genetic evidence for involvement of type 1,type 2and type 3inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor

1997 • 415 citations

Interaction of EGF receptor and Grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy

2000 • 301 citations

Lymphocyte Apoptosis: Mediation by Increased Type 3 Inositol 1,4,5-Trisphosphate Receptor

1996 • 268 citations

T Cells Deficient in Inositol 1,4,5-Trisphosphate Receptor Are Resistant to Apoptosis

1997 • 259 citations

Prohibitin, an antiproliferative protein, is localized to mitochondria

1995 • 184 citations

Control of apoptosis by IP3and ryanodine receptor driven calcium signals

2000 • 151 citations

Expression of Functional Receptor-coupled TRPC3 Channels in DT40 Triple Receptor InsP3 knockout Cells

2001 • 144 citations

Pro-Apoptotic Apoptosis Protease–Activating Factor 1 (Apaf-1) Has a Cytoplasmic Localization Distinct from Bcl-2 or Bcl-XL

2000 • 142 citations

Quantal calcium release by purified reconstituted inositol 1,4,5-trisphosphate receptors

1992 • 136 citations

Detergent solubility of the inositol trisphosphate receptor in rat brain membranes. Evidence for association of the receptor with ankyrin.

1993 • 130 citations

Inositol 1,4,5-Trisphosphate Receptor Type 1 Is a Substrate for Caspase-3 and Is Cleaved during Apoptosis in a Caspase-3-dependent Manner

1999 • 130 citations

Direct association of ligand-binding and pore domains in homo- and heterotetrameric inositol 1,4,5-trisphosphate receptors

2000 • 103 citations

Endoplasmic reticulum, Bcl-2 and Ca2+ handling in apoptosis

2002 • 98 citations

Type 3 inositol 1,4,5-trisphosphate receptor modulates cell death

2000 • 98 citations

Functional Properties of Recombinant Type I and Type III Inositol 1,4,5-Trisphosphate Receptor Isoforms Expressed in COS-7 Cells

2000 • 80 citations

Selective down-regulation of IP3receptor subtypes by caspases and calpain during TNF α -induced apoptosis of human T-lymphoma cells

2000 • 45 citations

Type 3 inositol 1,4,5‐trisphosphate receptor modulates cell death

2000 • 34 citations

Overexpressed Mitochondrial Hinge Protein, a Cytochromec-Binding Protein, Accelerates Apoptosis by Enhancing the Release of Cytochromecfrom Mitochondria

1998 • 27 citations