Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis

Mitochondria as the central control point of apoptosis

2000 • 1,875 citations

The Role of Dynamin-Related Protein 1, a Mediator of Mitochondrial Fission, in Apoptosis

2001 • 1,663 citations

Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

2000 • 1,370 citations

OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

2000 • 1,269 citations

Analysis of gene function in somatic mammalian cells using small interfering RNAs

2002 • 1,108 citations

A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis

2002 • 1,015 citations

The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast

1999 • 753 citations

A Human Dynamin-related Protein Controls the Distribution of Mitochondria

1998 • 711 citations

Mitochondrial Fusion in Human Cells Is Efficient, Requires the Inner Membrane Potential, and Is Mediated by Mitofusins

2002 • 633 citations

The human dynamin‐related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter‐membrane space

2002 • 401 citations

Nucleotide-dependent conformational changes in dynamin: evidence for a mechanochemical molecular spring

1999 • 380 citations

Mutation spectrum and splicing variants in the OPA1 gene

2001 • 370 citations

The Dynamin-Related Gtpase, Mgm1p, Is an Intermembrane Space Protein Required for Maintenance of Fusion Competent Mitochondria

2000 • 342 citations

Quantitation of mitochondrial alterations associated with apoptosis

2002 • 257 citations

Functional diversity in the dynamin family

1999 • 256 citations

Mitochondrial DNA maintenance in yeast requires a protein containing a region related to the GTP-binding domain of dynamin.

1992 • 249 citations

Garrotes, Springs, Ratchets, and Whips: Putting Dynamin Models to the Test

2000 • 215 citations

Cytochrome c as an electron shuttle between the outer and inner mitochondrial membranes.

1981 • 203 citations

Dynamin family of mechanoenzymes

2001 • 197 citations

HISTOPATHOLOGY OF EYE, OPTIC NERVE AND BRAIN IN A CASE OF DOMINANT OPTIC ATROPHY

1983 • 182 citations

The Yeast Dynamin-like Protein, Mgm1p, Functions on the Mitochondrial Outer Membrane to Mediate Mitochondrial Inheritance

1999 • 176 citations

Transforming growth factor beta 1-induced apoptosis in human ovarian carcinoma cells: protection by the antioxidant N-acetylcysteine and bcl-2.

1996 • 103 citations

A comprehensive survey of mutations in the OPA1 gene in patients with autosomal dominant optic atrophy.

2002 • 99 citations

Glaucomatous optic neuropathy: mechanisms of disease

2002 • 73 citations

Fission yeast msp1 is a mitochondrial dynamin-related protein

1999 • 66 citations

Characterization of antibodies specific for the caspase cleavage site on poly(ADP-ribose)polymerase: specific detection of apoptotic fragments and mapping of the necrotic fragments of poly(ADP-ribose)polymerase

1997 • 38 citations

Risk management of HBsAg or anti-HCV positive healthcare workers in hospital

2001 • 33 citations

Characterization of antibodies specific for the caspase cleavage site on poly(ADP-ribose) polymerase: specific detection of apoptotic fragments and mapping of the necrotic fragments of poly(ADP-ribose)polymerase

1997 • 30 citations