Proteasome activation as a critical event of thymocyte apoptosis

Mitochondria and Apoptosis

1998 • 8,909 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Caspases: killer proteases

1997 • 2,440 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Proteasome inhibitors: a novel class of potent and effective antitumor agents.

1999 • 1,447 citations

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)

1997 • 1,207 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1999 • 999 citations

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.

1995 • 791 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death

1997 • 470 citations

The role of the ubiquitin-proteasome pathway in apoptosis

1999 • 382 citations

Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis.

1996 • 353 citations

Proteasomes play an essential role in thymocyte apoptosis.

1996 • 316 citations

Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis.

1997 • 309 citations

Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.

1996 • 262 citations

Bcl-2, Bcl-xL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death

1997 • 248 citations

Proteasome Activation Occurs at an Early, Premitochondrial Step of Thymocyte Apoptosis

1998 • 90 citations

Changes in the Structure and Function of the Multicatalytic Proteinase (Proteasome) during Programmed Cell Death in the Intersegmental Muscles of the Hawkmoth, Manduca sexta

1995 • 86 citations

Catalytic Properties of 26 S and 20 S Proteasomes and Radiolabeling of MB1, LMP7, and C7 Subunits Associated with Trypsin-like and Chymotrypsin-like Activities

1997 • 64 citations

A 220-kDa Activator Complex of the 26 S Proteasome in Insects and Humans

1999 • 16 citations