Up-regulation of the proapoptotic mediators Bax and Bak after adenovirus-mediated p53 gene transfer in lung cancer cells.

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

1995 • 832 citations

Manipulation of Adenovirus Vectors

2003 • 780 citations

Identification of a p53-dependent negative response element in the bcl-2 gene.

1994 • 747 citations

Induction of apoptosis by the Bcl-2 homologue Bak

1995 • 738 citations

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1997 • 648 citations

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene.

1994 • 465 citations

Immunohistochemical analysis of in vivo patterns of Bcl-X expression.

1994 • 429 citations

Bcl-2 blocks p53-dependent apoptosis.

1994 • 371 citations

bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

1997 • 371 citations

High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus.

1994 • 257 citations

Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family.

1996 • 207 citations

Adenoviral-mediated wild-type p53 gene expression sensitizes colorectal cancer cells to ionizing radiation.

1996 • 180 citations

Overexpression of bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis

1996 • 170 citations

Gene therapy for lung cancer: Enhancement of tumor suppression by a combination of sequential systemic cisplatin and adenovirus-mediated p53 gene transfer

1996 • 140 citations

Induction of the death-promoting genebax-? sensitizes cultured breast-cancer cells to drug-induced apoptosis

1996 • 109 citations

Evidence that p53 and bcl-2 are regulators of a common cell death pathway important for in vivo lymphomagenesis.

1994 • 67 citations

Expression of wild-type p53 stimulates an increase in both Bax and Bcl-xL protein content in HT29 cells.

1996 • 48 citations