Betulinic acid: A new cytotoxic agent against malignant brain-tumor cells

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Apoptosis by Death Factor

1997 • 5,038 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Mitochondrial control of apoptosis

1997 • 1,500 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

1995 • 842 citations

The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells.

1997 • 456 citations

FLICE Is Predominantly Expressed as Two Functionally Active Isoforms, Caspase-8/a and Caspase-8/b

1997 • 405 citations

Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

1998 • 372 citations

Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors.

1997 • 347 citations

Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells.

1998 • 244 citations

Betulinic acid induces apoptosis in human neuroblastoma cell lines

1997 • 172 citations

Chemosensitivity of solid tumor cellsin vitro is related to activation of the CD95 system

1998 • 170 citations

Peroxynitrite and Nitric Oxide Donors Induce Neuronal Apoptosis by Eliciting Autocrine Excitotoxicity

1997 • 147 citations

Activation of the CD95 (APO-1/Fas) pathway in drug- and γ-irradiation-induced apoptosis of brain tumor cells

1998 • 129 citations

Medulloblastoma: tumor biological and clinical perspectives

1991 • 76 citations

CD95 (APO-1/Fas)-associating signalling proteins.

1996 • 76 citations

Cytotoxic Drugs, Programmed Cell Death, and the Immune System: Defining New Roles in an Old Play

1997 • 59 citations

Brain Tumor Working Group Report on the 9th International Conference on Brain Tumor Research and Therapy

1993 • 54 citations

Induction of p⁵³Without Increase in p21WAF1 in Betulinic Acid-Mediated Cell Death Is Preferential for Human Metastatic Melanoma

1998 • 47 citations

Descriptive epidemiology of primary central nervous system tumours in children: A population-based study

1991 • 45 citations

Tumor Inhibitors I: Preliminary Investigation of Antitumor Activity of Sarracenia flava

1974 • 41 citations

Tumor-Inhibitory Agent from Hyptis emoryi (Labiatae)

1972 • 32 citations