Protein Kinase Cδ Activation Induces Apoptosis in Response to Cardiac Ischemia and Reperfusion Damage

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse

1999 • 2,410 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

1999 • 1,753 citations

Protein Kinase C: Structure, Function, and Regulation

1995 • 1,640 citations

Apoptosis Signaling

2000 • 1,290 citations

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

1997 • 1,051 citations

Akt Promotes Survival of Cardiomyocytes In Vitro and Protects Against Ischemia-Reperfusion Injury in Mouse Heart

2000 • 834 citations

Defying death after DNA damage

2000 • 725 citations

Akt Activation Preserves Cardiac Function and Prevents Injury After Transient Cardiac Ischemia In Vivo

2001 • 686 citations

Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats.

1997 • 683 citations

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

2000 • 619 citations

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum.

1977 • 587 citations

Signaling Pathways in Reactive Oxygen Species–Induced Cardiomyocyte Apoptosis

1999 • 574 citations

Opposing cardioprotective actions and parallel hypertrophic effects of δPKC and ɛPKC

2001 • 540 citations

Caspases: key players in programmed cell death

2000 • 474 citations

Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells.

1982 • 417 citations

Regulation of cell apoptosis by protein kinase c delta.

2003 • 413 citations

Bid Is Cleaved by Calpain to an Active Fragment in Vitro and during Myocardial Ischemia/Reperfusion

2001 • 392 citations

A Selective ε-Protein Kinase C Antagonist Inhibits Protection of Cardiac Myocytes from Hypoxia-induced Cell Death

1997 • 386 citations

Sustained in vivo cardiac protection by a rationally designed peptide that causes ɛ protein kinase C translocation

1999 • 361 citations

Oxidative Modification and Inactivation of the Proteasome during Coronary Occlusion/Reperfusion

2001 • 349 citations

Morphological and Molecular Characterization of Adult Cardiomyocyte Apoptosis During Hypoxia and Reoxygenation

2000 • 312 citations

Mitochondrial Translocation of Protein Kinase C δ in Phorbol Ester-induced Cytochrome c Release and Apoptosis

2000 • 301 citations

An Inhibitor of p38 Mitogen-activated Protein Kinase Protects Neonatal Cardiac Myocytes from Ischemia

1999 • 300 citations

Apoptosis is Initiated by Myocardial Ischemia and Executed During Reperfusion

2000 • 284 citations

Apoptosis and myocardial infarction

1998 • 265 citations

Inhibition of δ-Protein Kinase C Protects Against Reperfusion Injury of the Ischemic Heart In Vivo

2003 • 265 citations

Cardiac reperfusion injury: Aging, lipid peroxidation, and mitochondrial dysfunction

1998 • 260 citations

Activation of c-Jun N-Terminal Kinases and p38-Mitogen-activated Protein Kinases in Human Heart Failure Secondary to Ischaemic Heart Disease

1999 • 216 citations

Involvement of CD95/Apo1/Fas in Cell Death After Myocardial Ischemia

2000 • 213 citations

Additive Protection of the Ischemic Heart Ex Vivo by Combined Treatment With δ-Protein Kinase C Inhibitor and ε-Protein Kinase C Activator

2003 • 202 citations

Involvement of Protein Kinase C δ (PKCδ) in Phorbol Ester-induced Apoptosis in LNCaP Prostate Cancer Cells

2000 • 200 citations

Cardiotrophic Effects of Protein Kinase C ε

2000 • 199 citations

Tyrosine Phosphorylation of Protein Kinase Cδ Is Essential for Its Apoptotic Effect in Response to Etoposide

2002 • 198 citations

Twisting integrin receptors increases endothelin-1 gene expression in endothelial cells

2001 • 193 citations

Transgenic Expression of Bcl-2 Modulates Energy Metabolism, Prevents Cytosolic Acidification During Ischemia, and Reduces Ischemia/Reperfusion Injury

2004 • 191 citations

Targeting of protein kinase C delta to mitochondria in the oxidative stress response.

2001 • 171 citations

Apoptosis Repressor with Caspase Recruitment Domain Protects against Cell Death by Interfering with Bax Activation

2004 • 170 citations

14-3-3 Inhibits Bad-Induced Cell Death through Interaction with Serine-136

2001 • 159 citations

Activation of c-Jun N-terminal kinase promotes survival of cardiac myocytes after oxidative stress

2002 • 158 citations

Differential Activation of Mitogen-Activated Protein Kinase Cascades and Apoptosis by Protein Kinase C ε and δ in Neonatal Rat Ventricular Myocytes

2001 • 152 citations

Protecting the ischaemic and reperfused myocardium in acute myocardial infarction: distant dream or near reality?

2000 • 148 citations

Heat Shock Protein 70 Gene Transfection Protects Mitochondrial and Ventricular Function Against Ischemia-Reperfusion Injury

2001 • 146 citations

Declines in mitochondrial respiration during cardiac reperfusion: Age-dependent inactivation of α-ketoglutarate dehydrogenase

1999 • 141 citations

Caspase Activation and Mitochondrial Cytochrome C Release during Hypoxia-mediated Apoptosis of Adult Ventricular Myocytes

2000 • 138 citations

Translocation of Protein Kinase Cε and Protein Kinase Cδ to Membrane Is Required for Ultraviolet B-induced Activation of Mitogen-activated Protein Kinases and Apoptosis

1999 • 137 citations

PKCδ Is Required for Mitochondrial-dependent Apoptosis in Salivary Epithelial Cells

2001 • 133 citations

Intermittent hypoxia attenuates ischemia/reperfusion induced apoptosis in cardiac myocytes via regulating Bcl-2/Bax expression

2003 • 127 citations

Opposing roles of δ and εPKC in cardiac ischemia and reperfusion: targeting the apoptotic machinery

2003 • 125 citations

Chelerythrine Rapidly Induces Apoptosis through Generation of Reactive Oxygen Species in Cardiac Myocytes

2001 • 118 citations

Survival-promoting functions of 14-3-3 proteins

2002 • 109 citations

Regulation of cardiac myocyte cell death

2003 • 103 citations

Activation of c-Jun N-terminal kinase promotes survival of cardiac myocytes after oxidative stress

2002 • 92 citations

Activation and Mitochondrial Translocation of Protein Kinase Cδ Are Necessary for Insulin Stimulation of Pyruvate Dehydrogenase Complex Activity in Muscle and Liver Cells

2001 • 91 citations

Modulation of the myocardial response to ischemia.

1998 • 85 citations

Acute inflammatory reaction after myocardial ischemic injury and reperfusion. Development and use of a neutrophil-specific antibody.

1996 • 79 citations

Enhanced apoptosis in prolonged cultures of senescent porcine pulmonary artery endothelial cells

2002 • 58 citations

Characterization of ultrastructure and its relation with DNA fragmentation in Fas-induced apoptosis of cultured cardiac myocytes

2001 • 55 citations

PKC-δ inhibits anchorage-dependent and -independent growth, enhances differentiation, and increases apoptosis in CaCo-2 cells

2001 • 54 citations

Adult alveolar epithelial cells express multiple subtypes of voltage-gated K⁺ channels that are located in apical membrane

2003 • 47 citations

Effect of tumor necrosis Factor-Alphaon endothelial and inducible nitric oxidesynthase messenger ribonucleic acidexpression and nitric oxide synthesisin ischemic and nonischemic isolated rat heart

2003 • 35 citations

The proapoptotic protein Bad binds the amphipathic groove of 14-3-3ζ

2001 • 28 citations

BAD Induces Apoptosis in Cells Over-Expressing Bcl-2 or Bcl-xL without Loss of Mitochondrial Membrane Potential

2001 • 18 citations

Low-flow Ischemia and Hypoxia Stimulate Apoptosis in Perfused Hearts Independently of Reperfusion

2002 • 17 citations