A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death

Mitochondria and Apoptosis

1998 • 8,909 citations

Caspases: Enemies Within

1998 • 6,923 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Mitochondrial control of cell death

2000 • 3,098 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

IAP family proteins---suppressors of apoptosis

1999 • 2,570 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

X-linked IAP is a direct inhibitor of cell-death proteases

1997 • 1,961 citations

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

1998 • 1,394 citations

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

1997 • 1,316 citations

IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.

1998 • 1,243 citations

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

2001 • 987 citations

An alternative, nonapoptotic form of programmed cell death

2000 • 930 citations

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

2000 • 842 citations

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

1999 • 750 citations

A Temperature-Dependent Switch from Chaperone to Protease in a Widely Conserved Heat Shock Protein

1999 • 747 citations

Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

2001 • 644 citations

A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.

1996 • 637 citations

A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases

1998 • 611 citations

The protein disulphide-isomerase family: unravelling a string of folds

1999 • 504 citations

Caspase-independent programmed cell death with necrotic morphology

1999 • 378 citations

An exegesis of IAPs: salvation and surprises from BIR motifs

1999 • 345 citations

The HtrA (DegP) protein, essential for Escherichia coli survival at high temperatures, is an endopeptidase

1990 • 317 citations

Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response

2000 • 270 citations

Sequence analysis and regulation of thehtrA gene ofEscherichin coli:a σ³²-independent mechanism of heat-inducible transcription

1988 • 259 citations

NMR Structure and Mutagenesis of the Third Bir Domain of the Inhibitor of Apoptosis Protein XIAP

2000 • 258 citations

XIAP, the guardian angel

2001 • 246 citations

X-linked Inhibitor of Apoptosis Protein (XIAP) Inhibits Caspase-3 and -7 in Distinct Modes

2001 • 234 citations

Characterization of a Novel Human Serine Protease That Has Extensive Homology to Bacterial Heat Shock Endoprotease HtrA and Is Regulated by Kidney Ischemia

2000 • 223 citations

Human HtrA, an Evolutionarily Conserved Serine Protease Identified as a Differentially Expressed Gene Product in Osteoarthritic Cartilage

1998 • 209 citations

Studies on a new proteolytic enzyme from Achromobacter lyticus M497-1 I. Purification and some enzymatic properties

1981 • 168 citations

An emerging blueprint for apoptosis in Drosophila

1999 • 151 citations

Production and separation of peptides from proteins stained with Coomassie brilliant blue R-250 after separation by sodium dodecyl sulfate-polyacrylamide gel electrophoresis

1990 • 118 citations

The Inhibitor of Apoptosis Protein-Binding Domain of Smac Is Not Essential for Its Proapoptotic Activity

2001 • 105 citations

Expression, Purification, and Functional Analysis of the Human Serine Protease HtrA2

2000 • 59 citations

Protease do is essential for survival of Escherichia coli at high temperatures: Its identity with the htrA gene product

1991 • 51 citations