Mitochondrial localization of p53 during adenovirus infection and regulation of its activity by E1B-19K

Surfing the p53 network

2000 • 6,487 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Live or let die: the cell's response to p53

2002 • 3,138 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Modelling for Survival Data in Medical Research

1995 • 2,227 citations

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

2001 • 2,226 citations

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

2000 • 2,064 citations

Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

2004 • 1,977 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

p53 Has a Direct Apoptogenic Role at the Mitochondria

2003 • 1,735 citations

PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

2001 • 1,275 citations

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

2003 • 1,266 citations

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

1999 • 1,044 citations

Death Signal-induced Localization of p53 Protein to Mitochondria

2000 • 883 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Transcriptional Repression of the Anti-apoptoticsurvivin Gene by Wild Type p53

2002 • 789 citations

Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex

2004 • 748 citations

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

1996 • 738 citations

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

1993 • 677 citations

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

1992 • 665 citations

E1A signaling to p53 involves the p19^ARFtumor suppressor

1998 • 614 citations

Transcriptional Cross Talk between NF-κB and p53

1999 • 590 citations

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

1992 • 567 citations

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

2003 • 551 citations

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

1995 • 546 citations

Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway

2002 • 534 citations

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation

1991 • 507 citations

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

1995 • 501 citations

Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex

2001 • 474 citations

Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins

1994 • 467 citations

Polyubiquitination of p53 by a Ubiquitin Ligase Activity of p300

2003 • 458 citations

Modelling Survival Data in Medical Research (2nd ed.) (Book)

2004 • 376 citations

The adenovirus death protein (E3-11.6K) is required at very late stages of infection for efficient cell lysis and release of adenovirus from infected cells

1996 • 370 citations

In Vivo Mitochondrial p53 Translocation Triggers a Rapid First Wave of Cell Death in Response to DNA Damage That Can Precede p53 Target Gene Activation

2004 • 368 citations

The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein.

1996 • 346 citations

Blockage by Adenovirus E4orf6 of Transcriptional Activation by the p53 Tumor Suppressor

1996 • 315 citations

Activation and activities of the p53 tumour suppressor protein

2001 • 307 citations

A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis.

1993 • 304 citations

Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription

2003 • 294 citations

Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.

1994 • 283 citations

Viral homologs of BCL-2: role of apoptosis in the regulation of virus infection

2002 • 280 citations

Regulation of p53 responses by post-translational modifications

2003 • 265 citations

Modelling Survival Data in Medical Research.

1995 • 257 citations

Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells

1997 • 244 citations

p53-dependent cell death/apoptosis is required for a productive adenovirus infection

1998 • 231 citations

Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells

1994 • 225 citations

Analysis of the Adenovirus E1B-55K-Anchored Proteome Reveals Its Link to Ubiquitination Machinery

2002 • 220 citations

Negative regulation of bcl-2 expression by p53 in hematopoietic cells

2001 • 210 citations

TP53 family members and human cancers

2003 • 210 citations

Regulation of p53 localization

2001 • 208 citations

Induction of Apoptosis by Human Nbk/Bik, a BH3-Containing Protein That Interacts with E1B 19K

1996 • 201 citations

Adenovirus type 5 early region 1b gene product is required for efficient shutoff of host protein synthesis

1984 • 186 citations

The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells

1998 • 182 citations

Oncogenic potential of the adenovirus E4orf6 protein.

1996 • 155 citations

Adenovirus E1A: remodelling the host cell, a life or death experience

2001 • 153 citations

Translational regulation of human p53 gene expression.

1996 • 139 citations

Interaction of adenoviral proteins with pRB and p53

1993 • 134 citations

Regulation of p53-dependent apoptosis, transcriptional repression, and cell transformation by phosphorylation of the 55-kilodalton E1B protein of human adenovirus type 5

1997 • 124 citations

Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53

2002 • 123 citations

Identification of Three Functions of the Adenovirus E4orf6 Protein That Mediate p53 Degradation by the E4orf6-E1B55K Complex

2001 • 112 citations

Defining the p53 DNA‐binding domain/Bcl‐x_L‐binding interface using NMR

2004 • 103 citations

Accumulation of p53 induced by the adenovirus E1A protein requires regions involved in the stimulation of DNA synthesis

1997 • 98 citations

Enhanced Expression of p53 in Human Cella Infected with Mutant Adenoviruses

1994 • 91 citations

p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis

1997 • 89 citations

Regulation of the 26S proteasome by adenovirus E1A

2000 • 88 citations

Human Tumor Viruses

1998 • 87 citations

Analyses of Single-Amino-Acid Substitution Mutants of Adenovirus Type 5 E1B-55K Protein

2001 • 82 citations

DNA sequence of the deletion/insertion in early region 3 of Ad5 dl309

1995 • 82 citations

A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function

2001 • 81 citations

p53's believe it or not: lessons on transcription-independent death.

2003 • 79 citations

Human tumor suppressor p53 and DNA viruses

2004 • 66 citations

Regulation of the mitochondrial checkpoint in p53-mediated apoptosis confers resistance to cell death

2002 • 65 citations

Adenovirus E1B 19-kDa Death Suppressor Protein Interacts with Bax but Not with Bad

1996 • 55 citations

Adenovirus cyt+ locus, which controls cell transformation and tumorigenicity, is an allele of lp+ locus, which codes for a 19-kilodalton tumor antigen

1984 • 52 citations

Deletion and insertion mutations in early region 1a of type 5 adenovirus that produce cold-sensitive or defective phenotypes for transformation

1984 • 45 citations

Stress-Induced p53 Runs a Direct Mitochondrial Death Program: Its Role in Physiologic and Pathophysiologic Stress Responses In Vivo

2004 • 43 citations

Mitochondrial p53 levels parallel total p53 levels independent of stress response in human colorectal carcinoma and glioblastoma cells

2004 • 43 citations

Control of Apoptosis by Human Adenovirus Genes

1998 • 43 citations

E1B-55-Kilodalton Protein Is Not Required To Block p53-Induced Transcription during Adenovirus Infection

2004 • 43 citations

Nuclear Envelope Localization of an Adenovirus Tumor Antigen Maintains the Integrity of Cellular DNA

1984 • 36 citations

Mutational analysis of the transforming and apoptosis suppression activities of the adenovirus E1 B 175R protein

1993 • 34 citations

Pro‐apoptotic activity of transiently expressed BCL‐2 occurs independent of BAX and BAK

2003 • 32 citations

The Adenovirus Oncoprotein E1a Stimulates Binding of Transcription Factor ETF to Transcriptionally Activate the p53 Gene

1999 • 28 citations

Requirement of BAX for Efficient Adenovirus-Induced Apoptosis

2002 • 25 citations

Introduction to DNA Tumor Viruses: Adenovirus, Simian Virus 40, and Polyomavirus

2014 • 19 citations