Apoptosis-Inducing Factor Is a Key Factor in Neuronal Cell Death Propagated by BAX-Dependent and BAX-Independent Mechanisms

Cell Death

2004 • 4,599 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Glutamate receptor ion channels

2005 • 3,667 citations

Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

2002 • 1,771 citations

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

2001 • 1,327 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

1997 • 1,020 citations

Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration

1997 • 994 citations

Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions

2002 • 964 citations

Specific Coupling of NMDA Receptor Activation to Nitric Oxide Neurotoxicity by PSD-95 Protein

1999 • 821 citations

Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity

2003 • 801 citations

Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis

2000 • 778 citations

Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.

1988 • 747 citations

Two Distinct Pathways Leading to Nuclear Apoptosis

2000 • 737 citations

Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process

1999 • 730 citations

Ischemic Brain Injury is Mediated by the Activation of Poly(ADP-Ribose)Polymerase

1997 • 624 citations

The harlequin mouse mutation downregulates apoptosis-inducing factor

2002 • 595 citations

Attenuation of Delayed Neuronal Death after Mild Focal Ischemia in Mice by Inhibition of the Caspase Family

1998 • 554 citations

Role of AIF in caspase-dependent and caspase-independent cell death

2004 • 511 citations

Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death

1999 • 495 citations

Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria

2002 • 491 citations

Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?

2002 • 490 citations

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

2002 • 485 citations

Diversity in the Mechanisms of Neuronal Cell Death

2003 • 468 citations

Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization

2003 • 434 citations

Glutamate receptor channels in rat DRG neurons: Activation by kainate and quisqualate and blockade of desensitization by con A

1990 • 420 citations

Bax Deletion Further Orders the Cell Death Pathway in Cerebellar Granule Cells and Suggests a Caspase-independent Pathway to Cell Death

1997 • 390 citations

Bax-Dependent Caspase-3 Activation Is a Key Determinant in p53-Induced Apoptosis in Neurons

1999 • 384 citations

Mechanisms of AIF-Mediated Apoptotic DNA Degradation in Caenorhabditis elegans

2002 • 375 citations

Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons

1995 • 366 citations

Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli

2002 • 312 citations

Involvement of apoptosis‐inducing factor in neuronal death after hypoxia‐ischemia in the neonatal rat brain

2003 • 288 citations

Apoptosis-Inducing Factor Substitutes for Caspase Executioners in NMDA-Triggered Excitotoxic Neuronal Death

2004 • 278 citations

NMDA But Not Non-NMDA Excitotoxicity is Mediated by Poly(ADP-Ribose) Polymerase

2000 • 216 citations

Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death

2001 • 203 citations

Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity

2003 • 193 citations

APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death

2001 • 190 citations

Differential modulation by cyclothiazide and concanavalin A of desensitization at native alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and kainate-preferring glutamate receptors.

1993 • 177 citations

Nuclear Translocation of Apoptosis-Inducing Factor after Focal Cerebral Ischemia

2004 • 167 citations

Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development

2002 • 157 citations

A new model of partial status epilepticus based on kindling

1982 • 152 citations

Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia

2001 • 143 citations

Hippocampal damage produced by systemic injections of domoic acid in mice

1991 • 135 citations

Chronic cerebral hypoperfusion elicits neuronal apoptosis and behavioral impairment

1998 • 130 citations

Apoptosis Inducing Factor and PARP‐Mediated Injury in the MPTP Mouse Model of Parkinson's Disease

2003 • 125 citations

CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation

2003 • 119 citations

Mechanisms of Caspase-Independent Neuronal Death: Energy Depletion and Free Radical Generation

2003 • 97 citations

Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke

2004 • 67 citations

The role of Bax in glutamate‐induced nerve cell death

2001 • 43 citations

A METHYL GREEN‐PYRONIN TECHNIQUE FOR DEMONSTRATING CELL DEATH IN THE MURINE TUMOUR S180

1994 • 29 citations

Periodic acid-Schiff(PAS)-positive deposits in brain following kainic acid-induced seizures: relationships to fos induction, neuronal necrosis, reactive gliosis, and blood-brain barrier breakdown

1995 • 27 citations

Improved cytochemical methods for demonstrating cell death using LR White as an embedding medium.

1998 • 14 citations