Movement of Bax from the Cytosol to Mitochondria during Apoptosis

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

FACS-optimized mutants of the green fluorescent protein (GFP)

1996 • 2,539 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

Mitochondrial control of apoptosis

1997 • 1,500 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

Cytosol-to-membrane redistribution of Bax and Bcl-X_Lduring apoptosis

1997 • 1,117 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Nuclear Membrane Dynamics and Reassembly in Living Cells: Targeting of an Inner Nuclear Membrane Protein in Interphase and Mitosis

1997 • 753 citations

BAX Is Required for Neuronal Death after Trophic Factor Deprivation and during Development

1996 • 745 citations

Inactivation of Bcl-2 by phosphorylation.

1995 • 744 citations

Photobleaching recovery and anisotropy decay of green fluorescent protein GFP-S65T in solution and cells: cytoplasmic viscosity probed by green fluorescent protein translational and rotational diffusion

1997 • 609 citations

Channel formation by antiapoptotic protein Bcl-2

1997 • 604 citations

Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview

1992 • 600 citations

Nonionic Detergents Induce Dimerization among Members of the Bcl-2 Family

1997 • 583 citations

Bcl-2 Phosphorylation Required for Anti-apoptosis Function

1997 • 540 citations

Diffusional Mobility of Golgi Proteins in Membranes of Living Cells

1996 • 499 citations

Diphtheria toxin entry into cells is facilitated by low pH.

1980 • 467 citations

bcl-xLx is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria

1994 • 435 citations

Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence.

1993 • 390 citations

Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera.

1996 • 376 citations

The entry of diphtheria toxin into the mammalian cell cytoplasm: evidence for lysosomal involvement.

1980 • 372 citations

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

1997 • 368 citations

Ultrastructural localization of bcl-2 protein.

1992 • 351 citations

The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation.

1989 • 349 citations

The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein.

1996 • 346 citations

Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.

1996 • 335 citations

Structure-Function Comparisons of the Proapoptotic Protein Bax in Yeast and Mammalian Cells

1996 • 280 citations

Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis.

1994 • 222 citations

Analysis of MAP 4 function in living cells using green fluorescent protein (GFP) chimeras.

1995 • 195 citations

Characterization of the protein product of bcl-2, the gene involved in human follicular lymphoma.

1987 • 191 citations

The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis.

1994 • 186 citations

Structure-function analysis of the Bcl-2 oncoprotein. Addition of a heterologous transmembrane domain to portions of the Bcl-2 beta protein restores function as a regulator of cell survival

1993 • 185 citations

Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells.

1992 • 169 citations

Role of membrane anchor domain of Bcl-2 in suppression of apoptosis caused by E1B-defective adenovirus

1994 • 167 citations

Analysis of Trafficking of Rev and Transdominant Rev Proteins in Living Cells Using Green Fluorescent Protein Fusions: Transdominant Rev Blocks the Export of Rev from the Nucleus to the Cytoplasm1

1995 • 114 citations

GFP in mammalian cells

1995 • 95 citations

The bcl-2 Candidate Proto-Oncogene Product Is a 24-Kilodalton Integral-Membrane Protein Highly Expressed in Lymphoid Cell Lines and lymphomas Carrying the t(14;18) Translocation

1989 • 61 citations