Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Mitochondrial control of cell death

2000 • 3,098 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Biochemical Pathways of Caspase Activation During Apoptosis

1999 • 2,567 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 2,326 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

1998 • 1,381 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

JC‐1, but not DiOC₆(3) or rhodamine 123, is a reliable fluorescent probe to assess ΔΨ changes in intact cells: implications for studies on mitochondrial functionality during apoptosis

1997 • 982 citations

Bax interacts with the permeability transition pore to induce permeability transition and cytochromecrelease in isolated mitochondria

1998 • 932 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

The central executioners of apoptosis: caspases or mitochondria?

1998 • 772 citations

Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis

1997 • 663 citations

Rapid Communication: Oxidative Stress Induces Apoptosis in Embryonic Cortical Neurons

1994 • 588 citations

Liver Transplantation

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Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas

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A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation.

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Liver Biopsy Interpretation

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Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: A placebo-controlled trial

1992 • 449 citations

Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis

1996 • 440 citations

The Mitochondrial Permeability Transition Is Required for Tumor Necrosis Factor Alpha-Mediated Apoptosis and Cytochrome c Release

1998 • 400 citations

Ursodeoxycholic Acid May Inhibit Deoxycholic Acid-Induced Apoptosis by Modulating Mitochondrial Transmembrane Potential and Reactive Oxygen Species Production

1998 • 327 citations

Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with simian virus 40.

1994 • 320 citations

Cytochemical Methods for the Detection of Apoptosis

1999 • 316 citations

Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids

1995 • 278 citations

Bile acid-induced liver toxicity: Relation to the hydrophobic-hydrophilic balance of bile acids

1986 • 271 citations

Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes.

1994 • 270 citations

Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation

1999 • 257 citations

Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes

1990 • 251 citations

Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium.

1993 • 251 citations

Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection.

1995 • 231 citations

Ursodeoxycholic acid for liver disease associated with cystic fibrosis: A double-blind multicenter trial

1996 • 225 citations

Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts

1991 • 221 citations

Toxicity of bile acids on the electron transport chain of isolated rat liver mitochondria

1994 • 211 citations

Hepatic injury induced by bile salts: Correlation between biochemical and morphological events

1990 • 207 citations

Ten-year survival in ursodeoxycholic acid-treated patients with primary biliary cirrhosis

1999 • 204 citations

Vitamin E reduces oxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the rat

1998 • 195 citations

Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes

1997 • 185 citations

Inhibition of apoptosis by antioxidants in the human HL-60 leukemia cell line

1995 • 177 citations

Role of Oxidant Stress in the Permeability Transition Induced in Rat Hepatic Mitochondria by Hydrophobic Bile Acids

2001 • 149 citations

Liver transplantation in pediatrics: Indications, contraindications, and pretransplant management

1991 • 146 citations

Bile salt-induced apoptosis of hepatocytes involves activation of protein kinase C

1997 • 122 citations

Trolox inhibits apoptosis in irradiated MOLT‐4 lymphocytes

1995 • 89 citations

Evidence for Accelerated Generation of Hydroxyl Radicals in Experimental Obstructive Jaundice of Rats

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Mitochondrial membrane perturbations in cholestasis

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Determination of bile acids in needle biopsies of human liver

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Tumor necrosis factor ? regulation of the Fas-mediated apoptosis-signaling pathway in synovial cells

1999 • 66 citations

Inhibition of Bile-Salt-Induced Hepatocyte Apoptosis by the Antioxidant Lazaroid U83836E

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Glutathione Status of Isolated Rat Hepatocytes Affects Bile Acid-Induced Cellular Necrosis But Not Apoptosis

2000 • 57 citations

Hepatocellular Transport of Bile Acids

1993 • 57 citations

Effect of Oxypurinol, a Xanthine Oxidase Inhibitor, on Hepatic Injury in the Bile Duct-Ligated Rat1

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Effects of vitamin E on the killing of cultured hepatocytes by tert-butyl hydroperoxide.

1992 • 41 citations

The effect of idebenone, a coenzyme Q analogue, on hydrophobic bile acid toxicity to isolated rat hepatocytes and hepatic mitochondria

1998 • 35 citations

Apoptosis induced in rat hepatocytes by in vivo exposure to taurochenodeoxycholate.

1997 • 29 citations

OXIDANT STRESS, APOPTOSIS AND NECROSIS IN ISOLATED RAT HEPATOCYTES EXPOSED TO BILE ACIDS

1998 • 1 citations