The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Bax interacts with the permeability transition pore to induce permeability transition and cytochromecrelease in isolated mitochondria

1998 • 932 citations

HIV-1: Fifteen Proteins and an RNA

1998 • 872 citations

Host factors and the pathogenesis of HIV-induced disease

1996 • 857 citations

Pathogenesis of human immunodeficiency virus infection

1993 • 835 citations

Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process

1999 • 730 citations

The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

1998 • 700 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans

1999 • 598 citations

The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis

1998 • 534 citations

Modulation of the Mitochondrial Permeability Transition Pore by Pyridine Nucleotides and Dithiol Oxidation at Two Separate Sites

1996 • 522 citations

Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of Jurkat cells

1999 • 518 citations

HIV-1 Vpr increases viral expression by manipulation of the cell cycle: A mechanism for selection of Vpr in vivo

1998 • 506 citations

Cyclophilin‐D binds strongly to complexes of the voltage‐dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore

1998 • 475 citations

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis.

1993 • 452 citations

The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling

1998 • 419 citations

Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux

1998 • 414 citations

HIV-1 Regulatory/Accessory Genes: Keys to Unraveling Viral and Host Cell Biology

1998 • 392 citations

HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state.

1995 • 386 citations

Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

1998 • 372 citations

Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest

1997 • 348 citations

HIV-1 Auxiliary Proteins: Making Connections in a Dying Cell

1998 • 328 citations

Arsenite Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore

1999 • 307 citations

Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis

1999 • 305 citations

Human immunodeficiency virus type 1 viral protein R localization in infected cells and virions

1993 • 275 citations

Serum Vpr regulates productive infection and latency of human immunodeficiency virus type 1.

1994 • 241 citations

HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor κB

1997 • 240 citations

Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel.

1993 • 239 citations

Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore

1999 • 211 citations

Inactivation of YME1, a member of the ftsH-SEC18-PAS1-CDC48 family of putative ATPase-encoding genes, causes increased escape of DNA from mitochondria in Saccharomyces cerevisiae.

1993 • 199 citations

Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2.

1996 • 195 citations

Establishment of a Cell-Free System of Neuronal Apoptosis: Comparison of Premitochondrial, Mitochondrial, and Postmitochondrial Phases

1997 • 188 citations

The fight of viruses against apoptosis

1998 • 177 citations

Regulation of apoptosis by BH3 domains in a cell-free system

1997 • 172 citations

Vpr Stimulates Viral Expression and Induces Cell Killing in Human Immunodeficiency Virus Type 1-Infected Dividing Jurkat T Cells

1998 • 168 citations

The thiol crosslinking agent diamide overcomes the apoptosis-inhibitory effect of Bcl-2 by enforcing mitochondrial permeability transition

1998 • 155 citations

Extracellular HIV-1 virus protein R causes a large inward current and cell death in cultured hippocampal neurons: Implications for AIDS pathology

1998 • 151 citations

Multicopy Suppressors of Phenotypes Resulting from the Absence of Yeast VDAC Encode a VDAC-like Protein

1997 • 148 citations

Mitochondrial dysfunctions in circulating T lymphocytes from human immunodeficiency virus-1 carriers [see comments]

1995 • 147 citations

The mitochondrial permeability transition: a new pathophysiological mechanism for Reye's syndrome and toxic liver injury.

1996 • 129 citations

A domain of human immunodeficiency virus type 1 Vpr containing repeated H(S/F)RIG amino acid motifs causes cell growth arrest and structural defects.

1995 • 129 citations

Site-directed Mutagenesis of the Yeast Mitochondrial ADP/ATP Translocator

1993 • 113 citations

Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Functions as an Immediate-Early Protein during HIV-1 Infection

1999 • 110 citations

The proapoptotic function ofDrosophilaHid is conserved in mammalian cells

1999 • 101 citations

NMR structure of the (52–96) C-terminal domain of the HIV-1 regulatory protein vpr: molecular insights into its biological functions 1 1Edited by P. E. Wright

1999 • 98 citations

ADP/ATP translocator is essential only for anaerobic growth of yeast Saccharomyces cerevisiae

1991 • 88 citations

Characterization of the ligand-binding site of the transferrin receptor in Trypanosoma brucei demonstrates a structural relationship with the N-terminal domain of the variant surface glycoprotein

1997 • 87 citations

Reaper-induced apoptosis in a vertebrate system

1997 • 80 citations

The Amino-Terminal Region of Vpr from Human Immunodeficiency Virus Type 1 Forms Ion Channels and Kills Neurons

1999 • 79 citations

The Zinc Fingers of HIV Nucleocapsid Protein NCp7 Direct Interactions with the Viral Regulatory Protein Vpr

1997 • 77 citations

Human Immunodeficiency Virus Induces a Dual Regulation of Bcl-2, Resulting in Persistent Infection of CD4⁺T- or Monocytic Cell Lines

1998 • 74 citations

Drosophila grim induces apoptosis in mammalian cells

1998 • 68 citations

Arginine Residues in the C-terminus of HIV-1 Vpr Are Important for Nuclear Localization and Cell Cycle Arrest

1998 • 59 citations

Direct binding to nucleic acids by Vpr of human immunodeficiency virus type 1

1998 • 52 citations

Inactivation of YME1, a Member of the ftsH-SEC18-PAS1-CDC48 Family of Putative ATPase-Encoding Genes, Causes Increased Escape of DNA from Mitochondria in Saccharomyces cerevisiae

1993 • 51 citations

Death of Bystander Cells by a Novel Pathway Involving Early Mitochondrial Damage in Human Immunodeficiency Virus–Related Lymphadenopathy

1997 • 49 citations

Extracellular addition of a domain of HIV‐1 Vpr containing the amino acid sequence motif H(S/F)RIG causes cell membrane permeabilization and death

1996 • 45 citations

HIV‐1 protein Vpr causes gross mitochondrial dysfunction in the yeast Saccharomyces cerevisiae

1997 • 41 citations

Peroxidative Modification of a Membrane Protein. Conformation-Dependent Chemical Modification of Adenine Nucleotide Translocase in Cu²⁺/tert-Butyl Hydroperoxide Treated Mitochondria

1996 • 26 citations

Death of Bystander Cells by a Novel Pathway Involving Early Mitochondrial Damage in Human Immunodeficiency Virus–Related Lymphadenopathy

1997 • 20 citations